Nucleotide excision repair (WP4753)

Homo sapiens

Nucleotide excision repair is a DNA repair mechanism that repairs DNA damaged by UV radiation. This type of damage produces bulky distortions in the shape of DNA double helix due to the addition of DNA adducts, mostly thymine dimers and 6,4-photoproducts. Recognition of distortions leads to the removal of a short single-stranded DNA segment that includes the lesion, creating a single-strand gap in the DNA, which is subsequently filled in by DNA polymerase, which uses the undamaged strand as a template. NER can be divided into two subpathways (Global genomic NER and Transcription coupled NER) that differ only in their recognition of helix-distorting DNA damage. Nucleotide excision repair has more complexity in eukaryotes. Nucleotide excision repair (NER) is a particularly important DNA repair mechanism as evidenced by the severe human diseases that result from in-born genetic mutations of NER proteins including Xeroderma pigmentosum and Cockayne's syndrome. This pathway was adapted from [ KEGG], [ REPAIRtoire] and [ Wikipedia]. The pathway layout is based on KEGG.


Kristina Hanspers , Eric Weitz , Finterly Hu , and Lars Willighagen


last edited

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Homo sapiens




Pathway Ontology

nucleotide excision repair pathway DNA repair pathway


Label Type Compact URI Comment
ERCC6 GeneProduct ensembl:ENSG00000225830
GTF2H5 GeneProduct ensembl:ENSG00000272047
GTF2H4 GeneProduct ensembl:ENSG00000213780
POLD1 GeneProduct ensembl:ENSG00000062822
RBX1 GeneProduct ensembl:ENSG00000100387
CUL4A GeneProduct ensembl:ENSG00000139842
CUL4B GeneProduct ensembl:ENSG00000158290
ERCC8 GeneProduct ensembl:ENSG00000049167
DDB1 GeneProduct ensembl:ENSG00000167986
ERCC5 GeneProduct ensembl:ENSG00000134899
XPA GeneProduct ensembl:ENSG00000136936
RPA1 GeneProduct ensembl:ENSG00000132383
CDK7 GeneProduct ensembl:ENSG00000134058
MNAT1 GeneProduct ensembl:ENSG00000020426
CCNH GeneProduct ensembl:ENSG00000134480
ERCC2 GeneProduct ensembl:ENSG00000104884
ERCC3 GeneProduct ensembl:ENSG00000163161
GTF2H1 GeneProduct ensembl:ENSG00000110768
GTF2H2 GeneProduct ensembl:ENSG00000145736
GTF2H3 GeneProduct ensembl:ENSG00000111358
ERCC1 GeneProduct ensembl:ENSG00000012061
ERCC4 GeneProduct ensembl:ENSG00000175595
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
PCNA GeneProduct ensembl:ENSG00000132646
RFC1 GeneProduct ensembl:ENSG00000035928
RFC2 GeneProduct ensembl:ENSG00000049541
RFC3 GeneProduct ensembl:ENSG00000133119
RFC4 GeneProduct ensembl:ENSG00000163918
RFC5 GeneProduct ensembl:ENSG00000111445
LIG1 GeneProduct ensembl:ENSG00000105486
RBX1 GeneProduct ensembl:ENSG00000100387
CUL4A GeneProduct ensembl:ENSG00000139842
CUL4B GeneProduct ensembl:ENSG00000158290
DDB2 GeneProduct ensembl:ENSG00000134574
DDB1 GeneProduct ensembl:ENSG00000167986
XPC GeneProduct ensembl:ENSG00000154767
RAD23A GeneProduct ensembl:ENSG00000179262
RAD23B GeneProduct ensembl:ENSG00000119318
CETN2 GeneProduct ensembl:ENSG00000147400
RPA2 GeneProduct ensembl:ENSG00000117748
RPA3 GeneProduct ensembl:ENSG00000106399


  1. KEGG Pathway: hsa03420
  2. REPAIRtoire: 2