VEGFA-VEGFR2 signaling (WP3888)

Homo sapiens

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Cited In

• A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo (2022).
• Protrudin regulates FAK activation, endothelial cell migration and angiogenesis (2022).
• Multidimensional Analysis of CHMP Family Members in Hepatocellular Carcinoma (2022).
• Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
• Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition (2020).
• Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis (2019).
• Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis (2018).
• VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis (2016).
• GediNET for discovering gene associations across diseases using knowledge based machine learning approach (2022).
• Characterization of the interactome profiling of Mycoplasma fermentans DnaK in cancer cells reveals interference with key cellular pathways (2022).

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References

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20. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Dougher M, Terman BI. Oncogene. 1999 Feb 25;18(8):1619–27. PubMed Europe PMC Scholia
21. Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165. Gengrinovitch S, Berman B, David G, Witte L, Neufeld G, Ron D. J Biol Chem. 1999 Apr 16;274(16):10816–22. PubMed Europe PMC Scholia
22. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Takahashi T, Ueno H, Shibuya M. Oncogene. 1999 Apr 1;18(13):2221–30. PubMed Europe PMC Scholia
23. Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. Marumo T, Schini-Kerth VB, Busse R. Diabetes. 1999 May;48(5):1131–7. PubMed Europe PMC Scholia
24. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP. J Biol Chem. 1999 May 28;274(22):15781–5. PubMed Europe PMC Scholia
25. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. Fujio Y, Walsh K. J Biol Chem. 1999 Jun 4;274(23):16349–54. PubMed Europe PMC Scholia
26. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. Kashige N, Carpino N, Kobayashi R. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2093–8. PubMed Europe PMC Scholia
27. Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. Bartoli M, Gu X, Tsai NT, Venema RC, Brooks SE, Marrero MB, et al. J Biol Chem. 2000 Oct 27;275(43):33189–92. PubMed Europe PMC Scholia
28. Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Sahni A, Francis CW. Blood. 2000 Dec 1;96(12):3772–8. PubMed Europe PMC Scholia
29. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY. J Biol Chem. 2001 Mar 9;276(10):7614–20. PubMed Europe PMC Scholia
30. Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation. Ikuta T, Ariga H, Matsumoto K. Genes Cells. 2000 Nov;5(11):913–27. PubMed Europe PMC Scholia
31. VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Qi JH, Claesson-Welsh L. Exp Cell Res. 2001 Feb 1;263(1):173–82. PubMed Europe PMC Scholia
32. Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+. Gliki G, Abu-Ghazaleh R, Jezequel S, Wheeler-Jones C, Zachary I. Biochem J. 2001 Feb 1;353(Pt 3):503–12. PubMed Europe PMC Scholia
33. VEGF transiently disrupts gap junctional communication in endothelial cells. Suarez S, Ballmer-Hofer K. J Cell Sci. 2001 Mar;114(Pt 6):1229–35. PubMed Europe PMC Scholia
34. Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. Dayanir V, Meyer RD, Lashkari K, Rahimi N. J Biol Chem. 2001 May 25;276(21):17686–92. PubMed Europe PMC Scholia
35. NCK and PAK participate in the signaling pathway by which vascular endothelial growth factor stimulates the assembly of focal adhesions. Stoletov KV, Ratcliffe KE, Spring SC, Terman BI. J Biol Chem. 2001 Jun 22;276(25):22748–55. PubMed Europe PMC Scholia
36. Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells. Dikov MM, Oyama T, Cheng P, Takahashi T, Takahashi K, Sepetavec T, et al. Cancer Res. 2001 Mar 1;61(5):2015–21. PubMed Europe PMC Scholia
37. Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase. Mayo LD, Kessler KM, Pincheira R, Warren RS, Donner DB. J Biol Chem. 2001 Jul 6;276(27):25184–9. PubMed Europe PMC Scholia
38. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. Takahashi T, Yamaguchi S, Chida K, Shibuya M. EMBO J. 2001 Jun 1;20(11):2768–78. PubMed Europe PMC Scholia
39. The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling. Giorgetti-Peraldi S, Murdaca J, Mas JC, Van Obberghen E. Oncogene. 2001 Jul 5;20(30):3959–68. PubMed Europe PMC Scholia
40. Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3’-kinase binding. Yu Y, Hulmes JD, Herley MT, Whitney RG, Crabb JW, Sato JD. Biochem J. 2001 Sep 1;358(Pt 2):465–72. PubMed Europe PMC Scholia
41. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, et al. Exp Cell Res. 2001 Sep 10;269(1):73–87. PubMed Europe PMC Scholia
42. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. Meadows KN, Bryant P, Pumiglia K. J Biol Chem. 2001 Dec 28;276(52):49289–98. PubMed Europe PMC Scholia
43. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I. Biochem J. 2001 Nov 15;360(Pt 1):255–64. PubMed Europe PMC Scholia
44. Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways. Bernatchez PN, Allen BG, Gélinas DS, Guillemette G, Sirois MG. Br J Pharmacol. 2001 Nov;134(6):1253–62. PubMed Europe PMC Scholia
45. Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. Colavitti R, Pani G, Bedogni B, Anzevino R, Borrello S, Waltenberger J, et al. J Biol Chem. 2002 Feb 1;277(5):3101–8. PubMed Europe PMC Scholia
46. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K ichi, et al. FASEB J. 2002 Feb;16(2):219–21. PubMed Europe PMC Scholia
47. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, et al. J Cell Biol. 2002 Apr 1;157(1):149–60. PubMed Europe PMC Scholia
48. Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, et al. Cancer Cell. 2002 Feb;1(1):99–108. PubMed Europe PMC Scholia
49. Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling. Stoletov KV, Ratcliffe KE, Terman BI. FASEB J. 2002 Aug;16(10):1283–5. PubMed Europe PMC Scholia
50. Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling. Ratcliffe KE, Tao Q, Yavuz B, Stoletov KV, Spring SC, Terman BI. Oncogene. 2002 Sep 12;21(41):6307–16. PubMed Europe PMC Scholia
51. KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA. Zeng H, Zhao D, Mukhopadhyay D. J Biol Chem. 2002 Nov 29;277(48):46791–8. PubMed Europe PMC Scholia
52. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Shu X, Wu W, Mosteller RD, Broek D. Mol Cell Biol. 2002 Nov;22(22):7758–68. PubMed Europe PMC Scholia
53. Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells. Usui T, Murai T, Tanaka T, Yamaguchi K, Nagakubo D, Lee CM, et al. Int Immunol. 2002 Nov;14(11):1273–82. PubMed Europe PMC Scholia
54. NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, et al. J Biol Chem. 2003 Jan 17;278(3):1686–92. PubMed Europe PMC Scholia
55. p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Voswinckel R, Gaumann A, et al. FASEB J. 2003 Feb;17(2):262–4. PubMed Europe PMC Scholia
56. Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Béliveau R. Mol Biol Cell. 2003 Jan;14(1):334–47. PubMed Europe PMC Scholia
57. Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. van Nieuw Amerongen GP, Koolwijk P, Versteilen A, van Hinsbergh VWM. Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):211–7. PubMed Europe PMC Scholia
58. Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability. Eriksson A, Cao R, Roy J, Tritsaris K, Wahlestedt C, Dissing S, et al. Circulation. 2003 Mar 25;107(11):1532–8. PubMed Europe PMC Scholia
59. Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells. Mac Gabhann F, Popel AS. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H153-64. PubMed Europe PMC Scholia
60. ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. Luque A, Carpizo DR, Iruela-Arispe ML. J Biol Chem. 2003 Jun 27;278(26):23656–65. PubMed Europe PMC Scholia
61. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, et al. J Cell Biol. 2003 May 26;161(4):793–804. PubMed Europe PMC Scholia
62. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, et al. J Biol Chem. 2003 Sep 19;278(38):36661–8. PubMed Europe PMC Scholia
63. Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1. Wu RF, Gu Y, Xu YC, Nwariaku FE, Terada LS. J Biol Chem. 2003 Sep 19;278(38):36830–40. PubMed Europe PMC Scholia
64. Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. Wang L, Zeng H, Wang P, Soker S, Mukhopadhyay D. J Biol Chem. 2003 Dec 5;278(49):48848–60. PubMed Europe PMC Scholia
65. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Prager GW, Breuss JM, Steurer S, Mihaly J, Binder BR. Blood. 2004 Feb 1;103(3):955–62. PubMed Europe PMC Scholia
66. Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. Liu D, Jia H, Holmes DIR, Stannard A, Zachary I. Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2002–7. PubMed Europe PMC Scholia
67. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, et al. Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):294–300. PubMed Europe PMC Scholia
68. Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Lamalice L, Houle F, Jourdan G, Huot J. Oncogene. 2004 Jan 15;23(2):434–45. PubMed Europe PMC Scholia
69. Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, et al. Blood. 2004 Jul 1;104(1):149–58. PubMed Europe PMC Scholia
70. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, et al. J Biol Chem. 2004 May 21;279(21):22267–75. PubMed Europe PMC Scholia
71. Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation. Stoletov KV, Gong C, Terman BI. Exp Cell Res. 2004 Apr 15;295(1):258–68. PubMed Europe PMC Scholia
72. Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor. Prager GW, Breuss JM, Steurer S, Olcaydu D, Mihaly J, Brunner PM, et al. Circ Res. 2004 Jun 25;94(12):1562–70. PubMed Europe PMC Scholia
73. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis. Chai J, Jones MK, Tarnawski AS. FASEB J. 2004 Aug;18(11):1264–6. PubMed Europe PMC Scholia
74. Nuclear factor of activated T cells balances angiogenesis activation and inhibition. Zaichuk TA, Shroff EH, Emmanuel R, Filleur S, Nelius T, Volpert OV. J Exp Med. 2004 Jun 7;199(11):1513–22. PubMed Europe PMC Scholia
75. Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. Stoletov KV, Terman BI. Biochem Biophys Res Commun. 2004 Jul 16;320(1):70–5. PubMed Europe PMC Scholia
76. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, et al. Circ Res. 2004 Aug 6;95(3):276–83. PubMed Europe PMC Scholia
77. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. Le Boeuf F, Houle F, Huot J. J Biol Chem. 2004 Sep 10;279(37):39175–85. PubMed Europe PMC Scholia
78. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C, Aird WC. J Biol Chem. 2004 Oct 15;279(42):44030–8. PubMed Europe PMC Scholia
79. p38 Mitogen-activated protein kinase regulation of endothelial cell migration depends on urokinase plasminogen activator expression. Yu J, Bian D, Mahanivong C, Cheng RK, Zhou W, Huang S. J Biol Chem. 2004 Nov 26;279(48):50446–54. PubMed Europe PMC Scholia
80. Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, et al. J Biol Chem. 2004 Nov 26;279(48):50537–54. PubMed Europe PMC Scholia
81. Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer. Neagoe PE, Lemieux C, Sirois MG. J Biol Chem. 2005 Mar 18;280(11):9904–12. PubMed Europe PMC Scholia
82. The vascular endothelial growth factor-induced disruption of gap junctions is relayed by an autocrine communication via ATP release in coronary capillary endothelium. Thuringer D. Ann N Y Acad Sci. 2004 Dec;1030:14–27. PubMed Europe PMC Scholia
83. Phospholipase Cgamma-Erk Axis in vascular endothelial growth factor-induced eukaryotic initiation factor 4E phosphorylation and protein synthesis in renal epithelial cells. Mariappan MM, Senthil D, Natarajan KS, Choudhury GG, Kasinath BS. J Biol Chem. 2005 Aug 5;280(31):28402–11. PubMed Europe PMC Scholia
84. Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx. Jho D, Mehta D, Ahmmed G, Gao XP, Tiruppathi C, Broman M, et al. Circ Res. 2005 Jun 24;96(12):1282–90. PubMed Europe PMC Scholia
85. Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor. Wong C, Jin ZG. J Biol Chem. 2005 Sep 30;280(39):33262–9. PubMed Europe PMC Scholia
86. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J. Cardiovasc Res. 2006 Feb 1;69(2):512–9. PubMed Europe PMC Scholia
87. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. Huang Y, Shi H, Zhou H, Song X, Yuan S, Luo Y. Blood. 2006 May 1;107(9):3564–71. PubMed Europe PMC Scholia
88. MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K. EMBO J. 2006 Feb 22;25(4):713–26. PubMed Europe PMC Scholia
89. Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. Marchand C, Favier J, Sirois MG. J Cell Biochem. 2006 Aug 1;98(5):1095–105. PubMed Europe PMC Scholia
90. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Bodnar RJ, Yates CC, Wells A. Circ Res. 2006 Mar 17;98(5):617–25. PubMed Europe PMC Scholia
91. Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability. Sun H, Breslin JW, Zhu J, Yuan SY, Wu MH. Microcirculation. 2006;13(3):237–47. PubMed Europe PMC Scholia
92. Diverse effects of vascular endothelial growth factor on human pulmonary endothelial barrier and migration. Mirzapoiazova T, Kolosova I, Usatyuk PV, Natarajan V, Verin AD. Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L718-24. PubMed Europe PMC Scholia
93. Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor. Le Boeuf F, Houle F, Sussman M, Huot J. Mol Biol Cell. 2006 Aug;17(8):3508–20. PubMed Europe PMC Scholia
94. The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase. Dance M, Montagner A, Yart A, Masri B, Audigier Y, Perret B, et al. J Biol Chem. 2006 Aug 11;281(32):23285–95. PubMed Europe PMC Scholia
95. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E. J Cell Biol. 2006 Aug 14;174(4):593–604. PubMed Europe PMC Scholia
96. Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. Lamalice L, Houle F, Huot J. J Biol Chem. 2006 Nov 10;281(45):34009–20. PubMed Europe PMC Scholia
97. The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association. Ali N, Yoshizumi M, Yano S, Sone S, Ohnishi H, Ishizawa K, et al. J Pharmacol Sci. 2006 Sep;102(1):112–20. PubMed Europe PMC Scholia
98. Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells. Ewan LC, Jopling HM, Jia H, Mittar S, Bagherzadeh A, Howell GJ, et al. Traffic. 2006 Sep;7(9):1270–82. PubMed Europe PMC Scholia
99. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Gavard J, Gutkind JS. Nat Cell Biol. 2006 Nov;8(11):1223–34. PubMed Europe PMC Scholia
100. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA. Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5106–15. PubMed Europe PMC Scholia
101. The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. Laramée M, Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, et al. J Biol Chem. 2007 Mar 16;282(11):7758–69. PubMed Europe PMC Scholia
102. AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Reihill JA, Ewart MA, Hardie DG, Salt IP. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1084–8. PubMed Europe PMC Scholia
103. Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells. Blanes MG, Oubaha M, Rautureau Y, Gratton JP. J Biol Chem. 2007 Apr 6;282(14):10660–9. PubMed Europe PMC Scholia
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