Circadian rhythm genes (WP3594)

Homo sapiens

This is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rhythm" annotation (taxon = homo sapiens). According to supplementary information they were clustered in major (neurotransmitters, hormons, appetite regulation and immune system) and minor groups. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Friederike Ehrhart , Martina Summer-Kutmon , Daniela Digles , Kristina Hanspers , Denise Slenter , and Eric Weitz


last edited

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Homo sapiens



Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
NPY2R GeneProduct uniprot:P49146
JUN GeneProduct uniprot:P05412
PAX4 GeneProduct uniprot:O43316
CRX GeneProduct uniprot:O43186
NPS GeneProduct uniprot:P0C0P6
ARNT2 GeneProduct uniprot:Q9HBZ2
ADA GeneProduct uniprot:P00813
CIPC GeneProduct uniprot:G3V5J4
DRD3 GeneProduct uniprot:P35462
CIPC GeneProduct uniprot:G3V3Y7
FAS GeneProduct uniprot:P25445
TH GeneProduct uniprot:P07101
CIPC GeneProduct uniprot:G3V5Y7
CIART GeneProduct uniprot:Q8N365
ATOH7 GeneProduct uniprot:Q8N100
PRKG2 GeneProduct uniprot:Q13237
PER1 GeneProduct uniprot:O15534
CLOCK GeneProduct uniprot:O15516
CDK4 GeneProduct uniprot:P11802
DRD4 GeneProduct uniprot:P21917
SFTPC GeneProduct uniprot:P11686
DRD1 GeneProduct uniprot:P21728
EGR1 GeneProduct uniprot:P18146
NCOA2 GeneProduct uniprot:Q15596
TYMS GeneProduct uniprot:P04818
HTR7 GeneProduct uniprot:P34969
ARNTL2 GeneProduct uniprot:Q8WYA1
ADIPOQ GeneProduct uniprot:Q15848
LEP GeneProduct uniprot:P41159
PER3 GeneProduct uniprot:Q8TAR6
SLC9A3 GeneProduct uniprot:P48764
CST3 GeneProduct uniprot:P01034
HDAC3 GeneProduct uniprot:O15379
SLC6A4 GeneProduct uniprot:P31645
CREB1 GeneProduct uniprot:P16220
NCOR1 GeneProduct uniprot:O75376
HOMER1 GeneProduct uniprot:Q86YM7
PER2 GeneProduct uniprot:O15055
KLF10 GeneProduct uniprot:Q13118
AHCY GeneProduct uniprot:P23526
DBP GeneProduct uniprot:M0QXP1
DDX5 GeneProduct uniprot:P17844
SOX14 GeneProduct uniprot:O95416
NAGLU GeneProduct uniprot:P54802
TPH1 GeneProduct uniprot:P17752
ADORA1 GeneProduct uniprot:P30542
NTRK3 GeneProduct uniprot:Q16288
DDC GeneProduct uniprot:P20711
ID4 GeneProduct uniprot:P47928
MTTP GeneProduct uniprot:E9PBP6
KCNH7 GeneProduct uniprot:Q9NS40
PRF1 GeneProduct uniprot:P14222
HCRTR2 GeneProduct uniprot:O43614
HS3ST2 GeneProduct uniprot:Q9Y278
ATF5 GeneProduct uniprot:Q9Y2D1
DBP GeneProduct uniprot:Q10586
MTA1 GeneProduct uniprot:Q13330
NR1H3 GeneProduct uniprot:Q13133
PRKAA1 GeneProduct uniprot:Q13131
RBM4 GeneProduct uniprot:Q9BWF3
SREBF1 GeneProduct uniprot:P36956
GFPT1 GeneProduct uniprot:Q06210
RORA GeneProduct uniprot:P35398
KLF9 GeneProduct uniprot:Q13886
DYRK1A GeneProduct uniprot:Q13627
CUL1 GeneProduct uniprot:Q13616
HDAC1 GeneProduct uniprot:Q13547
METTL3 GeneProduct uniprot:Q86U44
ADORA2A GeneProduct uniprot:P29274
IL6 GeneProduct uniprot:P05231
STAR GeneProduct uniprot:P49675
HNF1B GeneProduct uniprot:P35680
ID3 GeneProduct uniprot:Q02535
NPAS2 GeneProduct uniprot:Q99743
SIX3 GeneProduct uniprot:O95343
NR2F6 GeneProduct uniprot:P10588
ARNT GeneProduct uniprot:P27540
CHRNB2 GeneProduct uniprot:P17787
AGRP GeneProduct uniprot:O00253
UTS2R GeneProduct uniprot:Q9UKP6
JUND GeneProduct uniprot:P17535
CLDN4 GeneProduct uniprot:O14493
BTBD9 GeneProduct uniprot:Q96Q07
SETX GeneProduct uniprot:Q7Z333
ADCY1 GeneProduct uniprot:Q08828
KCNMA1 GeneProduct uniprot:Q12791
CREM GeneProduct uniprot:Q03060
DRD2 GeneProduct uniprot:P14416
NTRK1 GeneProduct uniprot:P04629
KCND2 GeneProduct uniprot:Q9NZV8
PRKAA2 GeneProduct uniprot:P54646
OPRL1 GeneProduct uniprot:P41146
PROX1 GeneProduct uniprot:Q92786
TNFRSF11A GeneProduct uniprot:Q9Y6Q6
MAGED1 GeneProduct uniprot:Q9Y5V3
MC3R GeneProduct uniprot:P41968
PTGDS GeneProduct uniprot:P41222
OGT GeneProduct uniprot:O15294
EZH2 GeneProduct uniprot:Q15910
KDM5A GeneProduct uniprot:P29375
HDAC2 GeneProduct uniprot:Q92769
PPP1CC GeneProduct uniprot:P36873
GNA11 GeneProduct uniprot:P29992
NKX2-1 GeneProduct uniprot:P43699
RORB GeneProduct uniprot:Q92753
CCAR2 GeneProduct uniprot:Q8N163
SKP1 GeneProduct uniprot:P63208
PROK2 GeneProduct uniprot:Q9HC23
OPN3 GeneProduct uniprot:Q9H1Y3
SUV39H2 GeneProduct uniprot:Q9H5I1
ATF4 GeneProduct uniprot:P18848
OPN4 GeneProduct uniprot:Q9UHM6
MAGEL2 GeneProduct ensembl:ENSG00000254585
GHRL GeneProduct uniprot:Q9UBU3
FBXL21 GeneProduct ensembl:ENSG00000164616
F7 GeneProduct uniprot:P08709
TIMELESS GeneProduct uniprot:Q9UNS1
USP2 GeneProduct uniprot:O75604
NMS GeneProduct uniprot:Q5H8A3
SFPQ GeneProduct uniprot:P23246
ROCK2 GeneProduct uniprot:O75116
NR1D1 GeneProduct uniprot:P20393
NGFR GeneProduct uniprot:P08138
CRH GeneProduct uniprot:P06850
ARNTL GeneProduct uniprot:O00327
PSPC1 GeneProduct uniprot:Q8WXF1
NPAS2 GeneProduct uniprot:Q99743
PPARGC1A GeneProduct uniprot:Q9UBK2
TP53 GeneProduct uniprot:P04637
SIN3A GeneProduct uniprot:Q96ST3
PRKDC GeneProduct uniprot:P78527
BTRC GeneProduct uniprot:Q9Y297
THRAP3 GeneProduct uniprot:Q9Y2W1
FBXW11 GeneProduct uniprot:Q9UKB1
NOCT GeneProduct uniprot:Q9UK39
RAI1 GeneProduct uniprot:Q7Z5J4
TOP2A GeneProduct uniprot:P11388
TOP1 GeneProduct uniprot:P11387
CHRM1 GeneProduct uniprot:P11229
EP300 GeneProduct uniprot:Q09472
PRKCDBP GeneProduct uniprot:Q969G5
PRKCG GeneProduct uniprot:P05129
SERPINE1 GeneProduct uniprot:P05121
ZFHX3 GeneProduct uniprot:Q15911
NCOA2 GeneProduct uniprot:Q15596
NONO GeneProduct uniprot:Q15233
PROKR1 GeneProduct uniprot:Q8TCW9
ADCY1 GeneProduct uniprot:Q08828
SIRT1 GeneProduct uniprot:Q96EB6
HCRTR1 GeneProduct uniprot:O43613
NFIL3 GeneProduct uniprot:Q16649
AANAT GeneProduct uniprot:Q16613
CARTPT GeneProduct uniprot:Q16568
CRY1 GeneProduct uniprot:Q16526
HNRNPD GeneProduct uniprot:Q14103
GNAQ GeneProduct ensembl:ENSG00000156052
SIK1 GeneProduct uniprot:P57059
GSK3B GeneProduct uniprot:P49841
HCRTR2 GeneProduct uniprot:O43614
HCRTR1 GeneProduct uniprot:O43613
CSNK1E GeneProduct uniprot:P49674
SUV39H1 GeneProduct uniprot:O43463
RELB GeneProduct uniprot:Q01201
HNRNPU GeneProduct uniprot:Q00839
Q59FM5 GeneProduct uniprot:Q59FM5
FBXL3 GeneProduct uniprot:Q9UKT7
NLGN1 GeneProduct uniprot:Q8N2Q7
MTNR1B GeneProduct uniprot:P49286
UBA52 GeneProduct uniprot:P62987
RPS27A GeneProduct uniprot:P62979
PPP1CB GeneProduct uniprot:P62140
PPP1CB GeneProduct uniprot:P62140
PPP1CA GeneProduct uniprot:P62136
GHRH GeneProduct uniprot:P01286
AVP GeneProduct uniprot:P01185
EGR3 GeneProduct uniprot:Q06889
HEBP1 GeneProduct uniprot:Q9NRV9
PPARA GeneProduct uniprot:Q07869
CRTC1 GeneProduct uniprot:Q6UUV9
NRIP1 GeneProduct uniprot:P48552
CSNK1D GeneProduct uniprot:P48730
KMT2A GeneProduct uniprot:Q03164
NR1D2 GeneProduct uniprot:Q14995
RBM4B GeneProduct uniprot:Q9BQ04
MYBBP1A GeneProduct uniprot:Q9BQG0
UBE3A GeneProduct uniprot:Q05086
CIPC GeneProduct uniprot:Q9C0C6
PROKR2 GeneProduct uniprot:Q8NFJ6
ID2 GeneProduct uniprot:Q02363
PTEN GeneProduct uniprot:P60484
DHX9 GeneProduct uniprot:Q08211
MTNR1A GeneProduct uniprot:P48039
NOS2 GeneProduct uniprot:P35228
PHLPP1 GeneProduct uniprot:O60346
UTS2 GeneProduct uniprot:O95399
TPH2 GeneProduct uniprot:Q8IWU9
C1orf51 GeneProduct uniprot:Q5TB13
CIPC GeneProduct uniprot:G3V405
MAPK9 GeneProduct uniprot:P45984
MAPK8 GeneProduct uniprot:P45983
RORC GeneProduct uniprot:P51449
MAPK10 GeneProduct uniprot:P53779
UBC GeneProduct uniprot:P0CG48
PPARG GeneProduct uniprot:P37231
PASD1 GeneProduct uniprot:Q8IV76
CRY2 GeneProduct uniprot:Q49AN0
CPT1A GeneProduct uniprot:P50416
LGR4 GeneProduct uniprot:Q9BXB1
PML GeneProduct uniprot:P29590
PROK1 GeneProduct uniprot:P58294
NAMPT GeneProduct uniprot:P43490
AHR GeneProduct uniprot:P35869
BHLHE41 GeneProduct uniprot:Q9C0J9
PRMT5 GeneProduct uniprot:O14744
BHLHE40 GeneProduct uniprot:O14503
HOMER1 GeneProduct uniprot:Q86YM7
NRIP1 GeneProduct uniprot:P48552
PROKR2 GeneProduct uniprot:Q8NFJ6
C1orf51 GeneProduct uniprot:Q5TB13
AGRP GeneProduct uniprot:O00253
PROKR1 GeneProduct uniprot:Q8TCW9
SIRT1 GeneProduct uniprot:Q96EB6
PROK2 GeneProduct uniprot:Q9HC23
BHLHE41 GeneProduct uniprot:Q9C0J9
PRKAA1 GeneProduct uniprot:Q13131