Novel Jun-Dmp1 pathway (WP3654)

Mus musculus

Ras-Raf-MEK-ERK pathway interacting with Arf/Mdm2/p53 cell cycle pathway to regulate cell growth and proliferation. The signalling of a mitogen acts through the Ras-Raf-MEK-ERK pathway to inhibit the Rb protein and allow Myc and E2fs to continue into S phase and inhibits the Arf/Mdm2/p53 pathway leading to growth arrest or apoptosis. The Ras-Raf-MEK-ERK pathway also directly acts on the Arf/Mdm2/p53 pathway with Dmp1 to prevent tumor formation by activating Arf. Arf inhibits Mdm2 allowing p53 to lead the cell to growth arrest or apoptosis. This pathway is based on figure 7 from Sreeramaneni et al.


AAR&Co , Linda Rieswijk , Kristina Hanspers , Eric Weitz , and Egon Willighagen


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Mus musculus



Pathway Ontology

cell cycle pathway, mitotic Ras superfamily mediated signaling pathway


Label Type Compact URI Comment
Dmp1 GeneProduct ensembl:ENSMUSG00000029307
Arf GeneProduct ensembl:ENSMUSG00000048076 Arf Not Specified
Kras GeneProduct ensembl:ENSMUSG00000030265 Ras Not Specified
Junb GeneProduct ensembl:ENSMUSG00000052837
Mapk1 GeneProduct ensembl:ENSMUSG00000063358
Ink4a GeneProduct ensembl:ENSMUSG00000044303
Raf1 GeneProduct ensembl:ENSMUSG00000000441
Myc GeneProduct ensembl:ENSMUSG00000022346
Cdk4 GeneProduct ensembl:ENSMUSG00000006728
Ccnd1 GeneProduct ensembl:ENSMUSG00000070348
E2f1 GeneProduct ensembl:ENSMUSG00000027490
Rb1 GeneProduct ensembl:ENSMUSG00000022105
Ets1 GeneProduct ensembl:ENSMUSG00000032035
Map2k1 GeneProduct ensembl:ENSMUSG00000004936
Ets2 GeneProduct ensembl:ENSMUSG00000022895
Jun GeneProduct ensembl:ENSMUSG00000052684
p53 GeneProduct ensembl:ENSMUSG00000059552
Mdm2 GeneProduct ensembl:ENSMUSG00000020184
Ets2 GeneProduct ensembl:ENSMUSG00000022895
Ets1 GeneProduct ensembl:ENSMUSG00000032035
Rras GeneProduct ensembl:ENSMUSG00000038387 Ras Not Specified
Nras GeneProduct ensembl:ENSMUSG00000027852 Ras Not Specified
Hras GeneProduct ensembl:ENSMUSG00000025499 Ras Not Specified
Araf GeneProduct ensembl:ENSMUSG00000001127
Braf GeneProduct ensembl:ENSMUSG00000002413
Map2k2 GeneProduct ensembl:ENSMUSG00000035027
Mapk3 GeneProduct ensembl:ENSMUSG00000063065
Jun GeneProduct ensembl:ENSMUSG00000052684
Fos GeneProduct ensembl:ENSMUSG00000021250
Jun GeneProduct ensembl:ENSMUSG00000052684
Fos GeneProduct ensembl:ENSMUSG00000021250


  1. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K. Mol Cell Biol. 2005 Jan;25(1):220–32. PubMed Europe PMC Scholia