EPO receptor signaling (WP996)

Bos taurus

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
EPOR GeneProduct ensembl:ENSBTAG00000008197 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057
JAK2 GeneProduct ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
SRC GeneProduct ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
SHC1 GeneProduct ensembl:ENSBTAG00000019838 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
GRB2 GeneProduct ensembl:ENSBTAG00000004736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
PDK1 GeneProduct ensembl:ENSBTAG00000016836 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
PIK3CG GeneProduct ensembl:ENSBTAG00000020848 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
EPO GeneProduct ensembl:ENSBTAG00000003430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056
SOCS1 GeneProduct ensembl:ENSBTAG00000004386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
STAT5B GeneProduct ensembl:ENSBTAG00000010125 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
CISH GeneProduct ensembl:ENSBTAG00000022622 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154
STAT5A GeneProduct ensembl:ENSBTAG00000009496 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT3 GeneProduct ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
PTPRC GeneProduct ensembl:ENSBTAG00000023144 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788
PTPRU GeneProduct ensembl:ENSBTAG00000012848 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10076
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
SOS1 GeneProduct ensembl:ENSBTAG00000011643 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
IRS2 GeneProduct ensembl:ENSBTAG00000012019 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
IRS1 GeneProduct ensembl:ENSBTAG00000021308 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667
RASA1 GeneProduct ensembl:ENSBTAG00000009565 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia