Vitamin A1 and A5/X pathways (WP5397)
Homo sapiens
Vitamin A5/X pathway which shows how our food results in precursors from which Vitamin A5/X (9CBC, 9CDHBC, 9CDHROL-ES and 9CDKHROL) is metabolized which is converted into Vitamin A5/X acid (9CDHRA) which binds to RXR.
Authors
Egon Willighagen and Ash IyerActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
metabolic pathway of cofactors, vitamins, nutrients retinol metabolic pathway vitamin A and metabolites signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ATBC | Metabolite | wikidata:Q306135 | provitamin A1 |
| 9CDHROL-ES | Metabolite | wikidata:Q120868159 | |
| 9CDHROL | Metabolite | wikidata:Q120868469 | |
| 9CBC | Metabolite | wikidata:Q27135678 | |
| 9CDHBC | Metabolite | wikidata:Q120868409 | |
| 9CDHRA | Metabolite | wikidata:Q120868444 | vitamin A5/X acidBoth R and S forms bind, but R better. The R stereoisomer is patented |
| 9CDHRA-ES | Metabolite | wikidata:Q120868227 | |
| ATRA | Metabolite | pubchem.compound:444795 | vitamin A1 acid |
| ATRAL | Metabolite | pubchem.compound:638015 | vitamin A1 aldehyde |
| ATROL | Metabolite | pubchem.compound:445354 | vitamin A1 |
| ATROL-ES | Metabolite | wikidata:Q120868257 | vitamin A1 |
| RXRa | Protein | ncbigene:6256 | |
| RXRb | Protein | ncbigene:6257 | |
| RXRc | Protein | ncbigene:6258 | |
| RARa | Protein | ncbigene:5914 | |
| RARb | Protein | ncbigene:5915 | |
| RARg | Protein | ncbigene:5916 |
References
- An Endogenous Mammalian Retinoid X Receptor Ligand, At Last! de Lera ÁR, Krezel W, Rühl R. ChemMedChem [Internet]. 2016 May 6;11(10):1027–37. Available from: http://dx.doi.org/10.1002/cmdc.201600105 DOI Scholia
- 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. Rühl R, Krzyżosiak A, Niewiadomska-Cimicka A, Rochel N, Szeles L, Vaz B, et al. PLoS Genet. 2015 Jun 1;11(6):e1005213. PubMed Europe PMC Scholia
- Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling. Krężel W, Rivas A, Szklenar M, Ciancia M, Alvarez R, de Lera AR, et al. Nutrients. 2021 Mar 12;13(3):925. PubMed Europe PMC Scholia