Parkin-ubiquitin proteasomal system pathway (WP2359)

Homo sapiens

This pathway describes the Parkin-Ubiquitin proteasome degradation system. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Kristina Hanspers , Daniela Digles , Alex Pico , Eric Weitz , Friederike Ehrhart , and Egon Willighagen


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

ubiquitin/proteasome degradation pathway


Label Type Compact URI Comment
SEPTIN5 GeneProduct ensembl:ENSG00000184702
Caspase-1 GeneProduct ncbigene:834
TUBAL3 GeneProduct ncbigene:79861
HSPA8 GeneProduct ncbigene:3312
TUBA4A GeneProduct ncbigene:7277
UBCH7 GeneProduct ncbigene:7332
PSMD8 GeneProduct ncbigene:5714
UBE2G1 GeneProduct ncbigene:7326
UBE2G2 GeneProduct ncbigene:7327
UBCH8 GeneProduct ncbigene:9246
UBE2J1 GeneProduct ncbigene:51465
TUBB8 GeneProduct ncbigene:347688
Cyclin E GeneProduct ncbigene:898
UBE1 GeneProduct ncbigene:7317
PSMD11 GeneProduct ncbigene:5717
Cullin 1 GeneProduct ncbigene:8454
UBE2J2 GeneProduct ncbigene:118424
FBXW7 GeneProduct ncbigene:55294
Parkin GeneProduct ncbigene:5071
Synphilin 1 GeneProduct ncbigene:9627
CASK GeneProduct ncbigene:8573
Caspase-8 GeneProduct ncbigene:841
CHIP GeneProduct ncbigene:10273
PAELR GeneProduct ncbigene:2861
Alpha-synuclein GeneProduct ncbigene:6622
SIAH1 GeneProduct ncbigene:6477
DORFIN GeneProduct ncbigene:25897
SIAH2 GeneProduct ncbigene:6478
TUBA3E GeneProduct ncbigene:112714
TUBA3D GeneProduct ncbigene:113457
TUBA3C GeneProduct ncbigene:7278
TUBA1C GeneProduct ncbigene:84790
TUBA1B GeneProduct ncbigene:10376
TUBA1A GeneProduct ncbigene:7846
TUBA8 GeneProduct ncbigene:51807
TUBA4B GeneProduct ensembl:ENSG00000243910
TUBB6 GeneProduct ncbigene:84617
TUBB4Q GeneProduct ncbigene:56604
TUBB4 GeneProduct ncbigene:10382
TUBB3 GeneProduct ncbigene:10381
TUBB2C GeneProduct ncbigene:10383
TUBB2B GeneProduct ncbigene:347733
TUBB2A GeneProduct ncbigene:7280
TUBB1 GeneProduct ncbigene:81027
TUBB GeneProduct ncbigene:203068
PSMD10 GeneProduct ncbigene:5716
PSMD1 GeneProduct ncbigene:5707
PSMC6 GeneProduct ncbigene:5706
PSMC5 GeneProduct ncbigene:5705
PSMC4 GeneProduct ncbigene:5704
PSMC3 GeneProduct ncbigene:5702
PSMC2 GeneProduct ncbigene:5701
PSMC1 GeneProduct ncbigene:5700
PSMD7 GeneProduct ncbigene:5713
PSMD6 GeneProduct ncbigene:9861
PSMD5 GeneProduct ncbigene:5711
PSMD4 GeneProduct ncbigene:5710
PSMD3 GeneProduct ncbigene:5709
PSMD2 GeneProduct ncbigene:5708
PSMD14 GeneProduct ncbigene:10213
PSMD13 GeneProduct ncbigene:5719
PSMD12 GeneProduct ncbigene:5718
PSMD9 GeneProduct ncbigene:5715
HSPA7 GeneProduct ensembl:ENSG00000225217
HSPA6 GeneProduct ncbigene:3310
HSPA5 GeneProduct ncbigene:3309
HSPA4 GeneProduct ncbigene:3308
HSPA2 GeneProduct ncbigene:3306
HSPA1L GeneProduct ncbigene:3305
HSPA1B GeneProduct ncbigene:3304
HSPA1A GeneProduct ncbigene:3303
HSPA14 GeneProduct ncbigene:51182
HSPA9 GeneProduct ncbigene:3313


  1. Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis. Smith SB, Dampier W, Tozeren A, Brown JR, Magid-Slav M. PLoS One. 2012;7(3):e33174. PubMed Europe PMC Scholia