Heme biosynthesis (WP1221)

Anopheles gambiae

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The enzymatic process that produces heme is porphyrin synthesis. The process is highly conserved across biology. In humans, this pathway serves almost exclusively to form heme. Heme biosynthesis starts with the synthesis of D-Aminolevulinic acid (dALA or δALA) from the amino acid glycine and succinyl-CoA, which is produced in the TCA cycle (Krebs cycle). This reaction is catalyzed by ALA synthase, which is a rate-limiting enzyme that is regulated by intracellular glucose and heme levels. The major organs for heme synthesis are the liver and the bone marrow. Source: Adapted from Wikipedia.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Caroline Miller , Egon Willighagen , Martina Summer-Kutmon , Jonathan Mélius , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Organisms

Anopheles gambiae

Communities

Annotations

Pathway Ontology

heme biosynthetic pathway

Participants

Label Type Compact URI Comment
O₂ Metabolite hmdb:HMDB0001377
NH3 Metabolite hmdb:HMDB0000051
H₂O₂ Metabolite hmdb:HMDB0003125
CoA Metabolite hmdb:HMDB0001423
CO₂ Metabolite hmdb:HMDB0001967
H₂O Metabolite hmdb:HMDB0002111
Porphobilinogen Metabolite hmdb:HMDB0000245
AgaP_AGAP003719 GeneProduct ncbigene:1271452
AgaP_AGAP003704 GeneProduct ncbigene:1274381
AgaP_AGAP004749 GeneProduct ncbigene:1278476
AgaP_AGAP011080 GeneProduct ncbigene:3291232
AgaP_AGAP003184 GeneProduct ncbigene:1273856
AgaP_AGAP010935 GeneProduct ncbigene:1271017
AgaP_AGAP008064 GeneProduct ncbigene:1277887
AgaP_AGAP011895 GeneProduct ncbigene:1280765

References