Wnt signaling pathway (WP1135)

Canis familiaris

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].


Thomas Kelder , Daniela Digles , Kristina Hanspers , Egon Willighagen , Eric Weitz , and Finterly Hu


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Canis familiaris



Pathway Ontology

Wnt signaling pathway


Label Type Compact URI Comment
DVL3 GeneProduct ncbigene:478650
RHOA GeneProduct ncbigene:403954
RAC1 GeneProduct ncbigene:403955
PLAU GeneProduct ncbigene:403426
PRKCB GeneProduct ncbigene:489968
PRKCH GeneProduct ncbigene:490722
GSK3B GeneProduct ncbigene:478575 MOUSE:KG38 MOUSE
APC GeneProduct ncbigene:479139
WNT3A GeneProduct ncbigene:482208
FZD3 GeneProduct ncbigene:486093
MAPK9 GeneProduct ncbigene:474652
CSNK1E GeneProduct ncbigene:474510
CCND1 GeneProduct ncbigene:449028
LDLR GeneProduct ncbigene:100683160
PRKD1 GeneProduct ncbigene:609091
WNT7A GeneProduct ncbigene:607180
WNT11 GeneProduct ncbigene:485183
WNT1 GeneProduct ncbigene:486560
PRKCA GeneProduct ncbigene:490904
JUN GeneProduct ncbigene:609429
FZD10 GeneProduct ncbigene:486232
FZD7 GeneProduct ncbigene:488478
PPP2R5C GeneProduct ncbigene:480436
WNT5B GeneProduct ncbigene:486756
CTNNB1 GeneProduct ncbigene:477032
WNT2 GeneProduct ncbigene:612141
PRKCE GeneProduct ncbigene:609934
WNT2B GeneProduct ncbigene:483220
SFRP4 GeneProduct ncbigene:483258
PRKCG GeneProduct ncbigene:484316
PAFAH1B1 GeneProduct ncbigene:480656
DVL2 GeneProduct ncbigene:489464
WNT6 GeneProduct ncbigene:488527
CCND3 GeneProduct ncbigene:608847
WNT5A GeneProduct ncbigene:484721
FZD1 GeneProduct ncbigene:482294
WNT16 GeneProduct ncbigene:612328
FZD6 GeneProduct ncbigene:403610
WNT4 GeneProduct ncbigene:612367
PPP2R5E GeneProduct ncbigene:480349
WNT3 GeneProduct ncbigene:609107
AXIN1 GeneProduct ncbigene:490099
WNT10B GeneProduct ncbigene:486561
PRKCQ GeneProduct ncbigene:478013
FZD5 GeneProduct ncbigene:488493
WNT7B GeneProduct ncbigene:481206
DVL1 GeneProduct ncbigene:489593
PRKCI GeneProduct ncbigene:478686
WNT10A GeneProduct ncbigene:488528
FOSL1 GeneProduct ncbigene:483724
MAPK10 GeneProduct ncbigene:478464
MYC GeneProduct ncbigene:403924
PRKCZ GeneProduct ncbigene:479577
CCND2 GeneProduct ncbigene:611782
FZD9 GeneProduct ncbigene:489809
FBXW2 GeneProduct ncbigene:610990
PRKCD GeneProduct ncbigene:494005
TCF-1/LEF GeneProduct ncbigene:478507
WNT16 GeneProduct ncbigene:612328
FZD2 GeneProduct ncbigene:490937


  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia