Kinin-Kallikrein pathway (WP5089)
Homo sapiens
Kinin-Kallikrein pathway for bradykinin formation that leads to bradykinin receptor 1 (BDKRB1) and receptor 2 (BDKRB2) activation in Homo sapiens starting from FXII.
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Authors
Aria Jadhav , Marvin Martens , Eric Weitz , and Daniela DiglesActivity
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Cited In
- Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
- Comparative RNA-Sequencing Analysis Reveals High Complexity and Heterogeneity of Transcriptomic and Immune Profiles in Hepatocellular Carcinoma Tumors of Viral (HBV, HCV) and Non-Viral Etiology (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
kallikrein-kinin cascade pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Des-arg(9)-bradykinin | Metabolite | chebi:133068 | |
| SERPING1 | GeneProduct | ensembl:ENSG00000149131 | |
| KLKB1 | GeneProduct | ensembl:ENSG00000164344 | |
| F12 | GeneProduct | ensembl:ENSG00000131187 | |
| CPN1 | GeneProduct | ensembl:ENSG00000120054 | |
| KNG1 | GeneProduct | ensembl:ENSG00000113889 | |
| Bradykinin | Protein | ncbiprotein:9606 | |
| BDKRB1 | Protein | uniprot:G3V4Y2 | |
| BDKRB2 | Protein | ncbigene:624 |
References
- Human plasma kallikrein-kinin system: physiological and biochemical parameters. Bryant JW, Shariat-Madar Z. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234–50. PubMed Europe PMC Scholia
- A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, et al. Elife. 2020 Jul 7;9:e59177. PubMed Europe PMC Scholia