Kinin-Kallikrein pathway (WP5089)

Homo sapiens

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Kinin Kallikrein Pathway for Bradykinin formation

Authors

Aria Jadhav , Marvin Martens , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

kallikrein-kinin cascade pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
des-arg(9) bradykinin Metabolite chebi:133068
SERPING1 GeneProduct ensembl:ENSG00000149131
KLKB1 GeneProduct ensembl:ENSG00000164344
CPN1 GeneProduct ensembl:ENSG00000120054
Coagulation factor XII Protein uniprot:P00748
Bradykinin Protein ncbiprotein:9606
BDKRB1 Protein uniprot:G3V4Y2
BDKRB2 Protein ncbigene:624
Kininogen-1 Protein uniprot:P01042

References

  1. Human plasma kallikrein-kinin system: physiological and biochemical parameters. Bryant JW, Shariat-Madar Z. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234–50. PubMed Europe PMC Scholia
  2. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, et al. Elife. 2020 Jul 7;9:e59177. PubMed Europe PMC Scholia