Mitochondrial complex II assembly (WP4920)
Homo sapiens
Complex II or succinate dehydrogenase (quinone) is shared between the TCA cycle and the ETC. It has no proton pumping activity. It is composed of four subunits encoded by nDNA. Two subunits are hydrophillic, SDHA and SDHB, and two subunits are hydrophobic: SDHC and SDHD. Complex II assembly occurs through the independent maturation of these subunits mediated by subunit-specific chaperones.
Authors
Anna Baya Meuleman , Egon Willighagen , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
oxidative phosphorylation pathway electron transport chain pathwayReferences
- Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia