Mitochondrial complex IV assembly (WP4922)

Homo sapiens

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Complex IV or cytochrome c oxidase (COX) catalyses the oxidation of cytochrome c and the reduction of oxygen to water, coupled to proton translocation. Mammalian cIV contains 13 subunits. MT-CO1 is the largest catalytic subunit. MT-CO2 is the second core subunit. MT-CO3, the third core subunit has no direct catalytic role. The supernumerary subunits do not seem to have a catalytic role, but are thought to be important for the stabilization and regulation of the catalytic core. Complex IV is the only OXPHOS complex containing tissue-specific and developmentally regulated isoforms.

Authors

Anna Baya Meuleman , Marvin Martens , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

electron transport chain pathway oxidative phosphorylation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Copper Metabolite chebi:30052
Heme O Metabolite chebi:24480
Heme A Metabolite chebi:24479
Heme B Metabolite chebi:26355
Copper Metabolite chebi:30052
PET100 GeneProduct ensembl:ENSG00000229833
COX6C GeneProduct ensembl:ENSG00000164919
COX5B GeneProduct ensembl:ENSG00000135940
HIGD1A GeneProduct ensembl:ENSG00000181061
MT-CO2 GeneProduct ensembl:ENSG00000198712
CMC1 GeneProduct ensembl:ENSG00000187118
SURF1 GeneProduct ensembl:ENSG00000148290
COX7B GeneProduct ensembl:ENSG00000131174
COX6B1 GeneProduct ensembl:ENSG00000126267
COX16 GeneProduct ensembl:ENSG00000133983
SMIM20 GeneProduct ensembl:ENSG00000250317
COX7A2 GeneProduct ensembl:ENSG00000112695
COA3 GeneProduct ensembl:ENSG00000183978
COX19 GeneProduct ensembl:ENSG00000240230
COA6 GeneProduct ensembl:ENSG00000168275
COX18 GeneProduct ensembl:ENSG00000163626
COX6A1 GeneProduct ensembl:ENSG00000111775
SCO2 GeneProduct ensembl:ENSG00000130489
COX15 GeneProduct ensembl:ENSG00000014919
PET117 GeneProduct ensembl:ENSG00000232838
COX11 GeneProduct ensembl:ENSG00000166260
TACO1 GeneProduct ensembl:ENSG00000136463
COX5A GeneProduct ensembl:ENSG00000178741
COX8A GeneProduct ensembl:ENSG00000176340
COX7C GeneProduct ensembl:ENSG00000127184
NDUFA4 GeneProduct ensembl:ENSG00000189043
TMEM177 GeneProduct ensembl:ENSG00000144120
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
COX17 GeneProduct ensembl:ENSG00000138495
MT-CO3 GeneProduct ensembl:ENSG00000198938
COX4I1 GeneProduct ensembl:ENSG00000131143
COX10 GeneProduct ensembl:ENSG00000006695
COX20 GeneProduct ensembl:ENSG00000203667
PNKD GeneProduct ensembl:ENSG00000127838
TACO1 GeneProduct ensembl:ENSG00000136463
CMC1 GeneProduct ensembl:ENSG00000187118
COA3 GeneProduct ensembl:ENSG00000183978
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
TACO1 GeneProduct ensembl:ENSG00000136463
CMC1 GeneProduct ensembl:ENSG00000187118
COA3 GeneProduct ensembl:ENSG00000183978
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
TACO1 GeneProduct ensembl:ENSG00000136463
CMC1 GeneProduct ensembl:ENSG00000187118
COX17 GeneProduct ensembl:ENSG00000138495
COX18 GeneProduct ensembl:ENSG00000163626
MT-CO2 GeneProduct ensembl:ENSG00000198712
COX20 GeneProduct ensembl:ENSG00000203667
COX16 GeneProduct ensembl:ENSG00000133983
COA6 GeneProduct ensembl:ENSG00000168275
SCO2 GeneProduct ensembl:ENSG00000130489
TMEM177 GeneProduct ensembl:ENSG00000144120
MT-CO2 GeneProduct ensembl:ENSG00000198712
COX20 GeneProduct ensembl:ENSG00000203667
COX6C GeneProduct ensembl:ENSG00000164919
COX5B GeneProduct ensembl:ENSG00000135940
COX7B GeneProduct ensembl:ENSG00000131174
COX8A GeneProduct ensembl:ENSG00000176340
COX7C GeneProduct ensembl:ENSG00000127184
SURF1 GeneProduct ensembl:ENSG00000148290
SMIM20 GeneProduct ensembl:ENSG00000250317
CMC1 GeneProduct ensembl:ENSG00000187118
COA3 GeneProduct ensembl:ENSG00000183978
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
TACO1 GeneProduct ensembl:ENSG00000136463
COX16 GeneProduct ensembl:ENSG00000133983
COA6 GeneProduct ensembl:ENSG00000168275
SCO2 GeneProduct ensembl:ENSG00000130489
TMEM177 GeneProduct ensembl:ENSG00000144120
MT-CO2 GeneProduct ensembl:ENSG00000198712
COX20 GeneProduct ensembl:ENSG00000203667
COX6C GeneProduct ensembl:ENSG00000164919
COX5B GeneProduct ensembl:ENSG00000135940
COX7B GeneProduct ensembl:ENSG00000131174
COX8A GeneProduct ensembl:ENSG00000176340
COX7C GeneProduct ensembl:ENSG00000127184
PET100 GeneProduct ensembl:ENSG00000229833
PET117 GeneProduct ensembl:ENSG00000232838
PNKD GeneProduct ensembl:ENSG00000127838
SURF1 GeneProduct ensembl:ENSG00000148290
SMIM20 GeneProduct ensembl:ENSG00000250317
CMC1 GeneProduct ensembl:ENSG00000187118
COA3 GeneProduct ensembl:ENSG00000183978
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
TACO1 GeneProduct ensembl:ENSG00000136463
COX16 GeneProduct ensembl:ENSG00000133983
COA6 GeneProduct ensembl:ENSG00000168275
SCO2 GeneProduct ensembl:ENSG00000130489
TMEM177 GeneProduct ensembl:ENSG00000144120
MT-CO2 GeneProduct ensembl:ENSG00000198712
COX20 GeneProduct ensembl:ENSG00000203667
COX6C GeneProduct ensembl:ENSG00000164919
COX5B GeneProduct ensembl:ENSG00000135940
COX7B GeneProduct ensembl:ENSG00000131174
COX8A GeneProduct ensembl:ENSG00000176340
COX7C GeneProduct ensembl:ENSG00000127184
PET100 GeneProduct ensembl:ENSG00000229833
PET117 GeneProduct ensembl:ENSG00000232838
PNKD GeneProduct ensembl:ENSG00000127838
COX6B1 GeneProduct ensembl:ENSG00000126267
COX7A2 GeneProduct ensembl:ENSG00000112695
COX6A1 GeneProduct ensembl:ENSG00000111775
MT-CO3 GeneProduct ensembl:ENSG00000198938
SURF1 GeneProduct ensembl:ENSG00000148290
SMIM20 GeneProduct ensembl:ENSG00000250317
CMC1 GeneProduct ensembl:ENSG00000187118
COA3 GeneProduct ensembl:ENSG00000183978
COX14 GeneProduct ensembl:ENSG00000178449
MT-CO1 GeneProduct ensembl:ENSG00000198804
TACO1 GeneProduct ensembl:ENSG00000136463
COX16 GeneProduct ensembl:ENSG00000133983
COA6 GeneProduct ensembl:ENSG00000168275
SCO2 GeneProduct ensembl:ENSG00000130489
TMEM177 GeneProduct ensembl:ENSG00000144120
MT-CO2 GeneProduct ensembl:ENSG00000198712
COX20 GeneProduct ensembl:ENSG00000203667
COX6C GeneProduct ensembl:ENSG00000164919
COX5B GeneProduct ensembl:ENSG00000135940
COX7B GeneProduct ensembl:ENSG00000131174
COX8A GeneProduct ensembl:ENSG00000176340
COX7C GeneProduct ensembl:ENSG00000127184
PET100 GeneProduct ensembl:ENSG00000229833
PET117 GeneProduct ensembl:ENSG00000232838
PNKD GeneProduct ensembl:ENSG00000127838
COX6B1 GeneProduct ensembl:ENSG00000126267
COX7A2 GeneProduct ensembl:ENSG00000112695
COX6A1 GeneProduct ensembl:ENSG00000111775
MT-CO3 GeneProduct ensembl:ENSG00000198938
NDUFA4 GeneProduct ensembl:ENSG00000189043

References

  1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia