Macrophage-stimulating protein (MSP) signaling network map (WP5353)

Homo sapiens

A network map of macrophage-stimulating protein (MSP) signaling

Authors

Rex D A B , Ash Iyer , Alex Pico , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

breast cancer pathway cancer pathway

Disease Ontology

ovarian disease

Participants

Label Type Compact URI Comment
ZEB1 GeneProduct ncbigene:21417
SLUG GeneProduct ncbigene:20583
SIP1 GeneProduct ncbigene:9839
MST1 GeneProduct ncbigene:4485
ALP GeneProduct ncbigene:11691
BGLAP GeneProduct ncbigene:12096
BSP GeneProduct ncbigene:103993
SP7 GeneProduct ncbigene:170574
IL10 GeneProduct ncbigene:3586
MMP9 GeneProduct ncbigene:4318
IL1B GeneProduct ncbigene:3553
MMP9 GeneProduct ncbigene:4318
IL1B GeneProduct ncbigene:3553
TNF GeneProduct ncbigene:7124
ACO GeneProduct ncbigene:50681
CPT1A GeneProduct ncbigene:12894
PPARGC1A GeneProduct ncbigene:19017
rh-MST1 GeneProduct ncbigene:4485
MST1R GeneProduct ncbigene:4486
VEGFA GeneProduct ncbigene:7422
IFNB1 GeneProduct ncbigene:3456
MST1 Protein ncbigene:4485
MAPK1 Protein ncbigene:5594
MST1R Protein ncbigene:4486
MAPK3 Protein ncbigene:5595
SRC Protein ncbigene:6714
PLCG1 Protein ncbigene:5335
AKT1 Protein ncbigene:207
MTOR Protein ncbigene:2475
RPS6KB1 Protein ncbigene:6198
PDCD4 Protein ncbigene:27250
RPS6KA1 Protein ncbigene:6195
RPS6 Protein ncbigene:6194
COL4A1 Protein ncbigene:1282
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
PCNA Protein ncbigene:5111
ABL1 Protein ncbigene:25
AKT1 Protein ncbigene:207
MBD4 Protein ncbigene:4486
MST1R Protein ncbigene:4486
MST1 Protein ncbigene:4485
WNT10B Protein ncbigene:7480
DEK Protein ncbigene:110052
FZD1 Protein ncbigene:8321
CTNNB1 Protein ncbigene:12387
WNT10B Protein ncbigene:7480
CTNNB1 Protein ncbigene:12387
CLDN1 Protein ncbigene:9076
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
sf-MST1R Protein ncbigene:4486
SMAD2 Protein ncbigene:4087
SMAD3 Protein ncbigene:4088
PDPK1 Protein ncbigene:5170
AKT1 Protein ncbigene:207
CDH2 Protein ncbigene:1000
CDH1 Protein ncbigene:999
RPS6KA3 Protein ncbigene:6197
CDH1 Protein ncbigene:999
VIM Protein ncbigene:7431
MST1R Δ 165 Protein ncbigene:4486
PTEN Protein ncbigene:5728
MTOR Protein ncbigene:2475
AKT1 Protein ncbigene:207
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
MST1R Protein ncbigene:4486
sf-MST1R Protein ncbigene:4486
AKT1 Protein ncbigene:207
GSK3B Protein ncbigene:2932
CTNNB1 Protein ncbigene:1499
GLUT1 Protein ncbigene:6513
LDHA Protein ncbigene:3939
HK2 Protein ncbigene:3099
MST1R Protein ncbigene:4486
SMAD9 Protein ncbigene:55994
SMAD5 Protein ncbigene:17129
SMAD1 Protein ncbigene:17125
ZEB2 Protein ncbigene:9839
VIM Protein ncbigene:7431
CDH1 Protein ncbigene:999
MST1R Protein ncbigene:4486
AKT1 Protein ncbigene:207
MTOR Protein ncbigene:2475
RPS6KB1 Protein ncbigene:6198
JUN Protein ncbigene:3725
MAPK3 Protein ncbigene:5595
MAPK1 Protein ncbigene:5594
RPS6KA4 Protein ncbigene:8986
TP53 Protein ncbigene:7157
RPS6KA5 Protein ncbigene:9252
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
SMAD1 Protein ncbigene:4086
SMAD5 Protein ncbigene:4090
SMAD9 Protein ncbigene:4093
MST1 p.R703C Protein refseq:NP_066278
MST1R Protein ncbigene:4486
AKT1 Protein ncbigene:207
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
PRKAA2 Protein ncbigene:5563
ACACA Protein ncbigene:31
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
PTK2 Protein ncbigene:5747
AKT1 Protein ncbigene:207
SRC Protein ncbigene:6714
MAPK3 Protein ncbigene:5595
MAPK3 Protein ncbigene:5595
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
CDH1 Protein ncbigene:999
ACTA2 Protein ncbigene:59
MST1R Protein ncbigene:4486
NFKB1 Protein ncbigene:4790
NFKB1 Protein ncbigene:4790
TNF Protein ncbigene:7124
IL1B Protein ncbigene:3553
IL10 Protein ncbigene:3586
MST1R Protein ncbigene:4486
SRC Protein ncbigene:6714
SMAD2 Protein ncbigene:4087
SMAD3 Protein ncbigene:4088
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
MAPK8 Protein ncbigene:5599
MAPK9 Protein ncbigene:5601
MAPK14 Protein ncbigene:1432
SMAD4 Protein ncbigene:4091
IGF1R Protein ncbigene:3480
FGFR1 Protein ncbigene:2260
VEGFR1 Protein ncbigene:2321
VEGFR2 Protein ncbigene:3791
PDGFRA Protein ncbigene:5156
PDGFRB Protein ncbigene:5159
CDH2 Protein ncbigene:1000
VIM Protein ncbigene:7431
TGFB1 Protein ncbigene:7040
ACTA2 Protein ncbigene:59
FN1 Protein ncbigene:2335
CDH1 Protein ncbigene:999
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
STAT3 Protein ncbigene:4088
STAT1 Protein ncbigene:17125
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
MAPK8 Protein ncbigene:5599
MAPK9 Protein ncbigene:5601
MAPK14 Protein ncbigene:1432
SOCS1 Protein ncbigene:12703
SOCS3 Protein ncbigene:12702
NR0B2 Protein ncbigene:23957
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
PTK2 Protein ncbigene:5747
MST1R Protein ncbigene:4486
STAT3 Protein ncbigene:20848
AKT1 Protein ncbigene:207
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
MAPK14 Protein ncbigene:1432
EGR1 Protein ncbigene:13653
FOS Protein ncbigene:14281
NR4A1 Protein ncbigene:15370
DUSP1 Protein ncbigene:19252
DUSP6 Protein ncbigene:67603
IL6 Protein ncbigene:16193
CXCL2 Protein ncbigene:20310
CXCL10 Protein ncbigene:15945
MST1R Protein ncbigene:4486
GAB1 Protein ncbigene:2549
CTNNB1 Protein ncbigene:1499
CTNNB1 Protein ncbigene:1499
CLDN5 Protein ncbigene:12741
OCLN Protein ncbigene:18260
TJP1 Protein ncbigene:21872
MST1 Protein ncbigene:4485
MST1R Protein ncbigene:4486
MAPK1 Protein ncbigene:5594
MAPK8 Protein ncbigene:5599
PLCG1 Protein ncbigene:5335
PIK3R1 Protein ncbigene:5295
SHC1 Protein ncbigene:6464
GRB2 Protein ncbigene:2885
PRKCB Protein ncbigene:5579
HSPB1 Protein ncbigene:3315
RAF1 Protein ncbigene:5894
NDRG1 Protein ncbigene:10397
ELK1 Protein ncbigene:2002
DUSP4 Protein ncbigene:1846
MST1R Protein ncbigene:4486
PIK3R1 Protein ncbigene:5295
RAF1 Protein ncbigene:5894
AKT1 Protein ncbigene:207
RPS6 Protein ncbigene:6194
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
PIK3R1 Protein ncbigene:5295
PDCD4 Protein ncbigene:27250
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
MAPK1 Protein ncbigene:5594
MAPK3 Protein ncbigene:5595
CRKL Protein ncbigene:1399
PIK3CA Protein ncbigene:207
NFKB1 Protein ncbigene:4790
RELA Protein ncbigene:5970
CXCL8 Protein ncbigene:3576
CXCL5 Protein ncbigene:6374
CXCL1 Protein ncbigene:2919
SIX1 Protein ncbigene:6495
CTNNB1 Protein ncbigene:1499
MST1R Protein ncbigene:4486
SRC Protein ncbigene:6714
MAP2K1 Protein ncbigene:5604
MAPK1 Protein ncbigene:5594
MAPK1 Protein ncbigene:5594
MAP2K2 Protein ncbigene:5605
PARP1 Protein ncbigene:142
ITGB1 Protein ncbigene:3688
IL10 Protein ncbigene:16153
CSF2 Protein ncbigene:12981
CCL2 Protein ncbigene:20296
CSF3 Protein ncbigene:12985
MST1 Protein ncbigene:4485
Ligand other than MST1 Protein ncbigene:7480

References

  1. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. Iwama A, Yamaguchi N, Suda T. EMBO J. 1996 Nov 1;15(21):5866–75. PubMed Europe PMC Scholia
  2. Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. Danilkovitch A, Skeel A, Leonard EJ. Exp Cell Res. 1999 May 1;248(2):575–82. PubMed Europe PMC Scholia
  3. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Danilkovitch A, Donley S, Skeel A, Leonard EJ. Mol Cell Biol. 2000 Mar;20(6):2218–27. PubMed Europe PMC Scholia
  4. RON-regulated innate immunity is protective in an animal model of multiple sclerosis. Tsutsui S, Noorbakhsh F, Sullivan A, Henderson AJ, Warren K, Toney-Earley K, et al. Ann Neurol. 2005 Jun;57(6):883–95. PubMed Europe PMC Scholia
  5. Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway. Gunella G, Bardelli C, Amoruso A, Viano I, Balbo P, Brunelleschi S. Br J Pharmacol. 2006 Jun;148(4):478–89. PubMed Europe PMC Scholia
  6. Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence. Côté M, Miller AD, Liu SL. Biochem Biophys Res Commun. 2007 Aug 17;360(1):219–25. PubMed Europe PMC Scholia
  7. Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility. Zhang K, Yao HP, Wang MH. Carcinogenesis. 2008 Mar;29(3):552–9. PubMed Europe PMC Scholia
  8. The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity. Wilson CB, Ray M, Lutz M, Sharda D, Xu J, Hankey PA. J Immunol. 2008 Aug 15;181(4):2303–10. PubMed Europe PMC Scholia
  9. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, et al. J Biol Chem. 2009 Oct 16;284(42):28510–21. PubMed Europe PMC Scholia
  10. The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. Thobe MN, Gurusamy D, Pathrose P, Waltz SE. Oncogene. 2010 Jan 14;29(2):214–26. PubMed Europe PMC Scholia
  11. Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein. Ma Q, Guin S, Padhye SS, Zhou YQ, Zhang RW, Wang MH. Mol Cancer. 2011 May 28;10:66. PubMed Europe PMC Scholia
  12. The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer. Zhao H, Chen MS, Lo YH, Waltz SE, Wang J, Ho PC, et al. Oncogene. 2014 Mar 13;33(11):1429–37. PubMed Europe PMC Scholia
  13. Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages. Chaudhuri A, Wilson NS, Yang B, Paler Martinez A, Liu J, Zhu C, et al. Immunol Cell Biol. 2013 Aug;91(7):451–60. PubMed Europe PMC Scholia
  14. The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming. Cunha S, Lin YC, Goossen EA, DeVette CI, Albertella MR, Thomson S, et al. Cell Rep. 2014 Jan 16;6(1):141–54. PubMed Europe PMC Scholia
  15. Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele. Kauder SE, Santell L, Mai E, Wright LY, Luis E, N’Diaye EN, et al. PLoS One. 2013 Dec 23;8(12):e83958. PubMed Europe PMC Scholia
  16. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, et al. Oncogene. 2015 Apr 30;34(18):2325–36. PubMed Europe PMC Scholia
  17. Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Moxley KM, Wang L, Welm AL, Bieniasz M. Genes Cancer. 2016 May;7(5–6):169–81. PubMed Europe PMC Scholia
  18. MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Chanda D, Li J, Oligschlaeger Y, Jeurissen MLJ, Houben T, Walenbergh SMA, et al. Exp Mol Med. 2016 Sep 9;48(9):e258. PubMed Europe PMC Scholia
  19. A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells. Ling Y, Kuang Y, Chen LL, Lao WF, Zhu YR, Wang LQ, et al. Oncotarget. 2017 Jun 13;8(24):39101–16. PubMed Europe PMC Scholia
  20. Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d’origine nantais dependent GAB1/Src/β-catenin pathway activation in a mouse model. Lu T, Wang Z, Prativa S, Xu Y, Wang T, Zhang Y, et al. J Neurochem. 2019 Jan;148(1):114–26. PubMed Europe PMC Scholia
  21. mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential. Faham N, Zhao L, Welm AL. NPJ Breast Cancer. 2018 Nov 9;4:36. PubMed Europe PMC Scholia
  22. When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All? Baird AM, Easty D, Jarzabek M, Shiels L, Soltermann A, Klebe S, et al. Front Endocrinol (Lausanne). 2019 Feb 26;10:89. PubMed Europe PMC Scholia
  23. RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells. Park JS, Choi HI, Kim DH, Kim CS, Bae EH, Ma SK, et al. Int J Mol Sci. 2019 Nov 4;20(21):5489. PubMed Europe PMC Scholia
  24. Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer. Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, et al. Cell Biol Toxicol. 2021 Feb;37(1):35–49. PubMed Europe PMC Scholia
  25. Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway. Jeong BC, Oh SH, Lee MN, Koh JT. J Bone Metab. 2020 Nov;27(4):267–79. PubMed Europe PMC Scholia
  26. RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma. Yu Q, Wang J, Li T, Xu X, Guo X, Ding S, et al. Biomed Res Int. 2021 Oct 19;2021:2282916. PubMed Europe PMC Scholia