Ectodysplasin A signaling in hair follicle development (WP3652)

Mus musculus

Ectodysplasin A protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.


AAR&Co , Susan Coort , Kristina Hanspers , Martina Summer-Kutmon , Laurent Winckers , Eric Weitz , and Egon Willighagen


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Mus musculus



Pathway Ontology

signaling pathway nuclear factor kappa B signaling pathway

Cell Type Ontology

hair follicle cell


Label Type Compact URI Comment
p50 GeneProduct ncbigene:18033
Rel GeneProduct ncbigene:19698
Nfkb2 GeneProduct ncbigene:18034
Relb GeneProduct ncbigene:19698
Ltb GeneProduct ncbigene:16994
Nfkb1 GeneProduct ncbigene:18033
Edar GeneProduct ncbigene:13608
Rela GeneProduct ncbigene:19697
Dkk4 GeneProduct ncbigene:234130
Sostdc1 GeneProduct ncbigene:66042
p65 GeneProduct ncbigene:19697
Relb GeneProduct ncbigene:19698
Edaradd GeneProduct ncbigene:171211
Dkk1 GeneProduct ncbigene:13380
Gli1 GeneProduct ncbigene:14632
Ptc GeneProduct ncbigene:19206
Shh GeneProduct ncbigene:20423
EDA-A5 isoform Protein uniprot:Q1L2D9
EDA-A1 isoform Protein uniprot:Q3UV69


  1. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142–7. PubMed Europe PMC Scholia