EDA signaling in hair follicle development (WP3652)
Mus musculus
EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.
Authors
AAR&Co , Susan Coort , Kristina Hanspers , Martina Summer-Kutmon , Laurent Winckers , Eric Weitz , and Egon WillighagenActivity
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Organisms
Mus musculusCommunities
Annotations
Cell Type Ontology
hair follicle cellPathway Ontology
nuclear factor kappa B signaling pathway signaling pathwayLabel | Type | Compact Identifier | Comment |
---|---|---|---|
Bmp | GeneProduct | ensembl:ENSMUSG00000022098 | |
p50 | GeneProduct | ensembl:ENSMUSG00000044475 | |
Rel | GeneProduct | ensembl:ENSMUSG00000020275 | |
Nfkb2 | GeneProduct | ensembl:ENSMUSG00000025225 | |
Relb | GeneProduct | ensembl:ENSMUSG00000002983 | |
Ltb | GeneProduct | ensembl:ENSMUSG00000024399 | |
Nfkb1 | GeneProduct | ensembl:ENSMUSG00000028163 | |
Edar | GeneProduct | ensembl:ENSMUSG00000003227 | |
Rela | GeneProduct | ensembl:ENSMUSG00000024927 | |
Dkk4 | GeneProduct | ensembl:ENSMUSG00000031535 | |
Sostdc1 | GeneProduct | ensembl:ENSMUSG00000036169 | |
p65 | GeneProduct | ensembl:ENSMUSG00000024927 | |
Relb | GeneProduct | ensembl:ENSMUSG00000002983 | |
Edaradd | GeneProduct | ensembl:ENSMUSG00000095105 | |
Dkk1 | GeneProduct | ensembl:ENSMUSG00000024868 | |
Gli1 | GeneProduct | ensembl:ENSMUSG00000025407 | |
Ptc | GeneProduct | ensembl:ENSMUSG00000021466 | |
Shh | GeneProduct | ensembl:ENSMUSG00000002633 | |
Protein Wnt | Protein | uniprot:A2A649 | |
EDA-A5 isoform | Protein | uniprot:Q1L2D9 | |
EDA-A1 isoform | Protein | uniprot:Q3UV69 |
References
- Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142–7. PubMed Europe PMC Scholia