EDA signaling in hair follicle development (WP3652)

Mus musculus

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EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

Authors

AAR&Co , Susan Coort , Kristina Hanspers , Martina Summer-Kutmon , Laurent Winckers , Eric Weitz , and Egon Willighagen

Activity

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Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

hair follicle cell

Pathway Ontology

nuclear factor kappa B signaling pathway signaling pathway

Participants

Label Type Compact Identifier Comment
Bmp GeneProduct ensembl:ENSMUSG00000022098
p50 GeneProduct ensembl:ENSMUSG00000044475
Rel GeneProduct ensembl:ENSMUSG00000020275
Nfkb2 GeneProduct ensembl:ENSMUSG00000025225
Relb GeneProduct ensembl:ENSMUSG00000002983
Ltb GeneProduct ensembl:ENSMUSG00000024399
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163
Edar GeneProduct ensembl:ENSMUSG00000003227
Rela GeneProduct ensembl:ENSMUSG00000024927
Dkk4 GeneProduct ensembl:ENSMUSG00000031535
Sostdc1 GeneProduct ensembl:ENSMUSG00000036169
p65 GeneProduct ensembl:ENSMUSG00000024927
Relb GeneProduct ensembl:ENSMUSG00000002983
Edaradd GeneProduct ensembl:ENSMUSG00000095105
Dkk1 GeneProduct ensembl:ENSMUSG00000024868
Gli1 GeneProduct ensembl:ENSMUSG00000025407
Ptc GeneProduct ensembl:ENSMUSG00000021466
Shh GeneProduct ensembl:ENSMUSG00000002633
Protein Wnt Protein uniprot:A2A649
EDA-A5 isoform Protein uniprot:Q1L2D9
EDA-A1 isoform Protein uniprot:Q3UV69

References

  1. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142–7. PubMed Europe PMC Scholia