EDA signaling in hair follicle development (WP3652)

Mus musculus

EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.


AAR&Co , Susan Coort , Kristina Hanspers , Martina Summer-Kutmon , Laurent Winckers , Eric Weitz , and Egon Willighagen


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited By

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus



Cell Type Ontology

hair follicle cell

Pathway Ontology

nuclear factor kappa B signaling pathway signaling pathway


Label Type Compact Identifier Comment
Bmp GeneProduct ensembl:ENSMUSG00000022098
p50 GeneProduct ensembl:ENSMUSG00000044475
Rel GeneProduct ensembl:ENSMUSG00000020275
Nfkb2 GeneProduct ensembl:ENSMUSG00000025225
Relb GeneProduct ensembl:ENSMUSG00000002983
Ltb GeneProduct ensembl:ENSMUSG00000024399
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163
Edar GeneProduct ensembl:ENSMUSG00000003227
Rela GeneProduct ensembl:ENSMUSG00000024927
Dkk4 GeneProduct ensembl:ENSMUSG00000031535
Sostdc1 GeneProduct ensembl:ENSMUSG00000036169
p65 GeneProduct ensembl:ENSMUSG00000024927
Relb GeneProduct ensembl:ENSMUSG00000002983
Edaradd GeneProduct ensembl:ENSMUSG00000095105
Dkk1 GeneProduct ensembl:ENSMUSG00000024868
Gli1 GeneProduct ensembl:ENSMUSG00000025407
Ptc GeneProduct ensembl:ENSMUSG00000021466
Shh GeneProduct ensembl:ENSMUSG00000002633
Protein Wnt Protein uniprot:A2A649
EDA-A5 isoform Protein uniprot:Q1L2D9
EDA-A1 isoform Protein uniprot:Q3UV69


  1. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142–7. PubMed Europe PMC Scholia