Hypoxia-dependent self-renewal of myoblasts (WP5023)

Mus musculus

Molecular mechanisms involved in self-renewal of satellite cells in hypoxia. Black arrows: activation of the signaling pathway / protein / molecule. Blunt red arrow: inhibition of the signaling pathway / protein / molecule. Round blue arrow: interaction between two pathways.


Maximilian Saller , Andra Waagmeester , Eric Weitz , Kristina Hanspers , and Egon Willighagen


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Mus musculus



Pathway Ontology

Notch signaling pathway Wnt signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
Hey1 GeneProduct ncbigene:15213
Hes1 GeneProduct ncbigene:15205
Hey2 GeneProduct ncbigene:15214
MYF5 GeneProduct ncbigene:17877
MYH GeneProduct ncbigene:17879
MYOD1 GeneProduct ncbigene:17927
CDKN1A GeneProduct ncbigene:12575
PAX7 GeneProduct ncbigene:18509
MYOG GeneProduct ncbigene:17928
Notch pathway GeneProduct ncbigene:18128
MAPK14 GeneProduct hgnc.symbol:MAPK14
FoxO1 GeneProduct ncbigene:56458
HIF1a GeneProduct ncbigene:15251
HSP90 GeneProduct ensembl:ENSMUSG00000020048


  1. Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation. Di Carlo A, De Mori R, Martelli F, Pompilio G, Capogrossi MC, Germani A. J Biol Chem. 2004 Apr 16;279(16):16332–8. PubMed Europe PMC Scholia
  2. Effects of hypoxia on proliferation and differentiation of myoblasts. Li X, Zhu L, Chen X, Fan M. Med Hypotheses. 2007;69(3):629–36. PubMed Europe PMC Scholia
  3. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, et al. J Clin Invest. 2007 Sep;117(9):2477–85. PubMed Europe PMC Scholia
  4. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Ren H, Accili D, Duan C. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5857–62. PubMed Europe PMC Scholia
  5. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, et al. J Cell Biol. 2010 Sep 6;190(5):867–79. PubMed Europe PMC Scholia
  6. miR-206 and -486 induce myoblast differentiation by downregulating Pax7. Dey BK, Gagan J, Dutta A. Mol Cell Biol. 2011 Jan;31(1):203–14. PubMed Europe PMC Scholia
  7. O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, et al. Mol Cell Biol. 2012 Jan;32(1):36–49. PubMed Europe PMC Scholia
  8. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Liu W, Wen Y, Bi P, Lai X, Liu XS, Liu X, et al. Development. 2012 Aug;139(16):2857–65. PubMed Europe PMC Scholia
  9. Muscle-specific microRNAs in skeletal muscle development. Horak M, Novak J, Bienertova-Vasku J. Dev Biol. 2016 Feb 1;410(1):1–13. PubMed Europe PMC Scholia
  10. Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice. Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, et al. FASEB J. 2019 Jul;33(7):8321–34. PubMed Europe PMC Scholia