Methylation pathways (WP704)

Homo sapiens

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This pathway describes the addition of methyl groups to small molecules. SAM, S-Adenosyl methionine, is utilized as a methyl donor and SAH is produced. This process is important in drug metabolism. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP704 CPTAC Assay Portal]

Authors

Pieter Giesbertz , Kristina Hanspers , Alex Pico , Martijn Van Iersel , Zahra Roudbari , Marianthi Kalafati , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

classic metabolic pathway protein modification pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
ATP Metabolite hmdb:HMDB0000538
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
L-Methionine Metabolite hmdb:HMDB0000696
Phosphate Metabolite hmdb:HMDB0001429
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
MAT1A GeneProduct ensembl:ENSG00000151224
MAT2A GeneProduct ensembl:ENSG00000168906
TPMT GeneProduct ensembl:ENSG00000137364
PNMT GeneProduct ensembl:ENSG00000141744
MAT2B GeneProduct ensembl:ENSG00000038274
HNMT GeneProduct ensembl:ENSG00000150540
INMT GeneProduct ensembl:ENSG00000241644
NNMT GeneProduct ensembl:ENSG00000166741
COMT GeneProduct ensembl:ENSG00000093010

References

  1. Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase. Weinshilboum RM. Cell Mol Neurobiol. 2006;26(4–6):539–61. PubMed Europe PMC Scholia
  2. The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes. Testa B, Krämer SD. Chem Biodivers. 2008 Nov;5(11):2171–336. PubMed Europe PMC Scholia