Fatty acid biosynthesis, initial steps (WP137)

Saccharomyces cerevisiae

Pyridoxal phosphate (PLP) is the active form of vitamin B6 and is a cofactor in many reactions of amino acid metabolism. Pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) are all forms of vitamin B6 that can be converted to PLP via the PLP salvage pathway. Most unicellular organisms and plants can synthesize PLP, whereas mammals cannot and require vitamin B6 in their diet. Thus far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis pathway as characterized in Escherichia coli (CITS: [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]). Saccharomyces cerevisiae synthesize PLP via the fungal type de novo PLP synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of the purine-cytosine permease family (CITS: [12649274]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Authors

Meredith Braymer , Christine Chichester , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

fatty acid biosynthetic pathway

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
malonyl-CoA Metabolite cas:524-14-1
NADPH Metabolite cas:53-57-6
Coenzyme A Metabolite cas:64885-97-8
phosphate Metabolite cas:14265-44-2
ADP Metabolite cas:58-64-0
acetyl-CoA Metabolite cas:72-89-9
ACC1 GeneProduct sgd:S000005299
FAS2 GeneProduct sgd:S000006152
FAS1 GeneProduct sgd:S000001665
MCT1 GeneProduct sgd:S000005747
HFA1 GeneProduct sgd:S000004820
CEM1 GeneProduct sgd:S000000863
OAR1 GeneProduct sgd:S000001538

References