Apoptosis (WP254)

Homo sapiens

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP254 CPTAC Assay Portal]


Alexander C. Zambon , Alex Pico , Thomas Kelder , Susan Coort , Angelika , Beth Lawlor , Martijn Van Iersel , Marc Gillespie , Kristina Hanspers , Jildau Bouwman , Anders Riutta , Nuno , Egon Willighagen , Martina Summer-Kutmon , Marianthi Kalafati , Josip , Anam , and Eric Weitz


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Homo sapiens


CPTAC PancCanNet


Pathway Ontology

apoptotic cell death pathway cell death pathway regulatory pathway


Label Type Compact URI Comment
MIR29B1 GeneProduct ensembl:ENSG00000283797
MIR29A GeneProduct ensembl:ENSG00000284032
PMAIP1 GeneProduct ncbigene:5366
CASP9 GeneProduct ncbigene:842
MDM2 GeneProduct ncbigene:4193
BAK1 GeneProduct ncbigene:578
TRAF3 GeneProduct ncbigene:7187
IRF1 GeneProduct ncbigene:3659
NFKB1 GeneProduct ncbigene:4790
FAS GeneProduct ncbigene:355
BIRC2 GeneProduct ncbigene:329
DIABLO GeneProduct ncbigene:56616
AKT1 GeneProduct ncbigene:207
GZMB GeneProduct ncbigene:3002
TNFRSF21 GeneProduct ncbigene:27242
BAD GeneProduct ncbigene:572
NFKBIA GeneProduct ncbigene:4792
CASP1 GeneProduct ncbigene:834
RIPK1 GeneProduct ncbigene:8737
IRF2 GeneProduct ncbigene:3660
NFKBIB GeneProduct ncbigene:4793
LTA GeneProduct ncbigene:4049
CASP4 GeneProduct ncbigene:837
IRF6 GeneProduct ncbigene:3664
CASP3 GeneProduct ncbigene:836
PRF1 GeneProduct ncbigene:5551
TNFRSF1A GeneProduct ncbigene:7132
IGF1R GeneProduct ncbigene:3480
RELA GeneProduct ncbigene:5970
CHUK GeneProduct ncbigene:1147
BAX GeneProduct ncbigene:581
APAF1 GeneProduct ncbigene:317
TNFRSF1B GeneProduct ncbigene:7133
CASP10 GeneProduct ncbigene:843
BIRC3 GeneProduct ncbigene:330
BID GeneProduct ncbigene:637
TNFRSF25 GeneProduct ncbigene:8718
MAPK10 GeneProduct ncbigene:5602
TRAF1 GeneProduct ncbigene:7185
IKBKB GeneProduct ncbigene:3551
IRF5 GeneProduct ncbigene:3663
DFFA GeneProduct ncbigene:1676
CYCS GeneProduct ncbigene:54205
NFKBIB GeneProduct ncbigene:4793
BBC3 GeneProduct ncbigene:27113
IRF3 GeneProduct ncbigene:3661
CASP2 GeneProduct ncbigene:835
HRK GeneProduct ncbigene:8739
TP73 GeneProduct ncbigene:7161
CASP11 GeneProduct ncbigene:9169
CASP7 GeneProduct ncbigene:840
MYC GeneProduct ncbigene:4609
TNF GeneProduct ncbigene:7124
IGF2 GeneProduct ncbigene:3481
CRADD GeneProduct ncbigene:8738
IKBKG GeneProduct ncbigene:8517
BOK GeneProduct ncbigene:666
TRAF2 GeneProduct ncbigene:7186
CFLAR GeneProduct ncbigene:8837
BCL2L2 GeneProduct ncbigene:599
PIK3R1 GeneProduct ncbigene:5295
TRADD GeneProduct ncbigene:8717
BIRC5 GeneProduct ncbigene:332
IGF1 GeneProduct ncbigene:3479
TNFRSF10B GeneProduct ncbigene:8795
JUN GeneProduct ncbigene:3725
BNIP3L GeneProduct ncbigene:665
DFFB GeneProduct ncbigene:1677
TRADD GeneProduct ncbigene:8717
BCL2 GeneProduct ncbigene:596
TNFRSF1A GeneProduct ncbigene:7132
IRF7 GeneProduct ncbigene:3665
RELA GeneProduct ncbigene:5970
BCL2L1 GeneProduct ncbigene:598
IRF4 GeneProduct ncbigene:3662
NFKBIE GeneProduct ncbigene:4794
TP53 GeneProduct ncbigene:7157
MAP2K4 GeneProduct ncbigene:6416
RIPK1 GeneProduct ncbigene:8737
CDKN2A GeneProduct ncbigene:1029
CASP8 GeneProduct ncbigene:841
BIRC4 GeneProduct ncbigene:331
BAD GeneProduct ncbigene:572
NFKBIA GeneProduct ncbigene:4792
FASLG GeneProduct ncbigene:356
TNFSF10 GeneProduct ncbigene:8743
NFKBIE GeneProduct ncbigene:4794
HELLS GeneProduct ncbigene:3070
NFKB1 GeneProduct ncbigene:4790
FADD GeneProduct ncbigene:8772
MCL1 GeneProduct ncbigene:4170
CASP6 GeneProduct ncbigene:839
BCL2L11 GeneProduct ncbigene:10018
MAP3K1 GeneProduct ncbigene:4214
TP63 GeneProduct ncbigene:8626
MIR29B2 GeneProduct ensembl:ENSG00000284203


  1. Regulation of p53 in response to DNA damage. Lakin ND, Jackson SP. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. The p53-MDM2 network: from oscillations to apoptosis. Bose I, Ghosh B. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia