Eicosanoid synthesis (WP167)

Homo sapiens

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]. This pathway has been updated with information from LIPID MAPS>Eicosanoids [https://lipidmaps.org/resources/pathways/vanted.php]. Metabolites and proteins from this pathway are orange coloured and have an rounded rectangle shape (where an rectangle shape indicates that the node only occures in the LIPID MAPS pathway). Reactions occurring in the LIPID MAPS pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LIPID MAPS pathway). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP167 CPTAC Assay Portal]


Andrew Kwa , Kristina Hanspers , Thomas Kelder , Carlos J Pirola , Alex Pico , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , Eric Weitz , and Conroy lipids


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Homo sapiens


Lipids and LIPID MAPS


Pathway Ontology

inflammatory response pathway eicosanoid biosynthetic pathway

Cell Type Ontology

epithelial cell


Label Type Compact URI Comment
5S-HETE Metabolite lipidmaps:LMFA03060002
5S-HPETE Metabolite lipidmaps:LMFA03060012
Prostaglandin H2 Metabolite lipidmaps:LMFA03010010
Leukotriene D4 Metabolite lipidmaps:LMFA03020006
Thromboxane B2 Metabolite lipidmaps:LMFA03030002
Prostaglandin I2 Metabolite lipidmaps:LMFA03010087
Prostaglandin D2 Metabolite lipidmaps:LMFA03010004
Leukotriene A4 Metabolite lipidmaps:LMFA03020023
Prostaglandin F2a Metabolite lipidmaps:LMFA03010002
Leukotriene C4 Metabolite lipidmaps:LMFA03020003
Leukotriene E4 Metabolite lipidmaps:LMFA03020002
12S-HETE Metabolite lipidmaps:LMFA03060007
15S-HETE Metabolite lipidmaps:LMFA03060001
Thromboxane A2 Metabolite lipidmaps:LMFA03030001
Arachidonic acid Metabolite lipidmaps:LMFA01030001
Leukotriene B4 Metabolite lipidmaps:LMFA03020001
PGD2 Metabolite lipidmaps:LMFA03010004
12S-HPETE Metabolite lipidmaps:LMFA03060013
15S-HPETE Metabolite lipidmaps:LMFA03060014
Prostaglandin E2 Metabolite lipidmaps:LMFA03010003
15-Dehydro-prostaglandin I2 Metabolite lipidmaps:LMFA03010205 Changed 15-oxo-prostaglandin I2 to 15-Dehydro-prostaglandin I2, since the enzyme listed mentions dehydrogenase, and pubchem mentions 15-Dehydro-prostaglandin I2 is created from Prostaglandin I2.
Thromboxane A3 Metabolite lipidmaps:LMFA03030005
Phospholipids containgingarachidonic acid Metabolite chebi:37739 AKA glycerophospholipids
PGG2 Metabolite lipidmaps:LMFA03010009
11-HETE Metabolite lipidmaps:LMFA03060085
PGJ2 Metabolite lipidmaps:LMFA03010019
15-deoxy-PGJ2 Metabolite lipidmaps:LMFA03010021
15-deoxy-PGD2 Metabolite lipidmaps:LMFA03010051
ALOX5AP GeneProduct uniprot:P20292
PTGDS GeneProduct uniprot:P41222
PTGES2 GeneProduct uniprot:Q9H7Z7
DPEP1 GeneProduct uniprot:P16444
PTGIS GeneProduct uniprot:Q16647
ALOX5 GeneProduct uniprot:P09917
TBXAS1 GeneProduct uniprot:P24557
GSH peroxidase GeneProduct eccode:
PTGS1 GeneProduct uniprot:P23219
CBR1 GeneProduct uniprot:P16152
GGT1 GeneProduct uniprot:P19440
ALOX5 GeneProduct uniprot:P09917
ALOX15B GeneProduct uniprot:O15296
PTGES GeneProduct uniprot:O14684
ALOX5 GeneProduct uniprot:P09917
LTA4H GeneProduct uniprot:P09960
PTGS2 GeneProduct uniprot:P35354
PRXL2B GeneProduct uniprot:Q8TBF2
LTC4S GeneProduct uniprot:Q16873
ALOX15 GeneProduct uniprot:P16050
ALOX5AP GeneProduct uniprot:P20292
Per-oxidase GeneProduct eccode:
ALOX12 GeneProduct uniprot:P18054
AKR1C3 GeneProduct uniprot:P42330 EC:
dehydrogenase GeneProduct eccode:
Pla2g5 GeneProduct uniprot:P39877
Pla2g6 GeneProduct uniprot:O60733
Pla2g4a GeneProduct uniprot:P47712
Pla2g4b GeneProduct uniprot:P0C869
Ptgs1 GeneProduct uniprot:P23219
Ptgs2 GeneProduct uniprot:P35354
ALOX5 GeneProduct uniprot:P09917
Ptgs1 GeneProduct uniprot:P23219
Ptgs2 GeneProduct uniprot:P35354


  1. Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase. Schieber A, Frank RW, Ghisla S. Eur J Biochem. 1992 Jun 1;206(2):491–502. PubMed Europe PMC Scholia
  2. Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney. Korff JM, Jarabak J. Methods Enzymol. 1982;86:152–5. PubMed Europe PMC Scholia
  3. cDNA cloning, expression and characterization of human prostaglandin F synthase. Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, et al. FEBS Lett. 1999 Dec 3;462(3):335–40. PubMed Europe PMC Scholia
  4. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia