In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]].
This pathway has been updated with information from LIPID MAPS>Eicosanoids [https://lipidmaps.org/resources/pathways/vanted.php].
Metabolites and proteins from this pathway are orange coloured and have an rounded rectangle shape (where an rectangle shape indicates that the node only occures in the LIPID MAPS pathway).
Reactions occurring in the LIPID MAPS pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LIPID MAPS pathway).
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP167 CPTAC Assay Portal]a1a1.1.1.189a05EC:1.1.1.188c72Changed 15-oxo-prostaglandin I2 to 15-Dehydro-prostaglandin I2, since the enzyme listed mentions dehydrogenase, and pubchem mentions 15-Dehydro-prostaglandin I2 is created from Prostaglandin I2.c54AKA glycerophospholipidsc54inflammatory response pathwayPW:0000024Pathway Ontologyepithelial cellCL:0000066Cell Type10622721PubMedcDNA cloning, expression and characterization of human prostaglandin F synthase.FEBS Lett1999Suzuki-Yamamoto TNishizawa MFukui MOkuda-Ashitaka ENakajima TIto SWatanabe Keicosanoid biosynthetic pathwayPW:0001239Pathway Ontology1597188PubMedPurification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.Eur J Biochem1992Schieber AFrank RWGhisla S6182444PubMed6182444PubMedIsolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney.Methods Enzymol1982Korff JMJarabak J11729303PubMedProstaglandins and leukotrienes: advances in eicosanoid biology.Science2001Funk CD