Burn wound healing (WP5056)

Mus musculus

This pathway is part of a systematic review on currently known molecular players in burn wound healing in mammalians.


Maximilian Saller , Egon Willighagen , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus



Pathway Ontology

cell-extracellular matrix signaling pathway immune response pathway

Cell Type Ontology

fibroblast endothelial cell keratinocyte myofibroblast cell


Label Type Compact URI Comment
L-Hydroxyproline Metabolite kegg.genes:C01157
NO Metabolite kegg.drug:C00533
Vegfa Protein uniprot:Q00731
PDRN Protein uniprot:P37913 Polydeoxyribonucleotide (PDRN)
Protein-ID might be incorrect, as the manuscript does not specify the compound for treatment
Nos3 Protein uniprot:P70313
EPO Protein uniprot:P01588
Lama1 Protein uniprot:P19137
Fn1 Protein uniprot:P02751
Col1a1 Protein uniprot:P11087
Tnf Protein uniprot:P06804
Hbegf Protein uniprot:Q06186
Tgfb1 Protein uniprot:P04202
Pecam1 Protein uniprot:Q08481
Tgfbrap1 Protein uniprot:Q3UR70
Nos2 Protein uniprot:P29477
Flii Protein uniprot:Q9JJ28
Acta1 Protein uniprot:P68134
Gja1 Protein uniprot:P23242 Type your comment here
Prodh2 Protein uniprot:Q8VCZ9 Hydroxyproline
Type your comment here
Nlrp3 Protein uniprot:Q8R4B8
TP53 Protein uniprot:Q9WUR6 Cavia Percellus
CCND1 Protein uniprot:A0A286XN48 Cavia Percellus


  1. Expression of cyclin protein after thermal skin injury in a guinea pig model. DeCherney AH, Dougherty WR, Felix JC, Rodgers KE, Girgis W, Abiko M, et al. J Burn Care Rehabil. 1997;18(4):292–8. PubMed Europe PMC Scholia
  2. Apoptosis and p53 protein expression increase in the process of burn wound healing in guinea-pig skin. Nagata M, Takenaka H, Shibagaki R, Kishimoto S. Br J Dermatol. 1999 May;140(5):829–38. PubMed Europe PMC Scholia
  3. Healing of burn wounds in transgenic mice overexpressing transforming growth factor-beta 1 in the epidermis. Yang L, Chan T, Demare J, Iwashina T, Ghahary A, Scott PG, et al. Am J Pathol. 2001 Dec;159(6):2147–57. PubMed Europe PMC Scholia
  4. Endogenous production of heparin-binding EGF-like growth factor during murine partial-thickness burn wound healing. Cribbs RK, Harding PA, Luquette MH, Besner GE. J Burn Care Rehabil. 2002;23(2):116–25. PubMed Europe PMC Scholia
  5. Effect of recombinant adeno-associated virus vector-mediated vascular endothelial growth factor gene transfer on wound healing after burn injury. Galeano M, Deodato B, Altavilla D, Squadrito G, Seminara P, Marini H, et al. Crit Care Med. 2003 Apr;31(4):1017–25. PubMed Europe PMC Scholia
  6. Limiting burn extension by transient inhibition of Connexin43 expression at the site of injury. Coutinho P, Qiu C, Frank S, Wang CM, Brown T, Green CR, et al. Br J Plast Surg. 2005 Jul;58(5):658–67. PubMed Europe PMC Scholia
  7. Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds. Galeano M, Altavilla D, Bitto A, Minutoli L, Calò M, Lo Cascio P, et al. Crit Care Med. 2006 Apr;34(4):1139–46. PubMed Europe PMC Scholia
  8. Differential cutaneous wound healing in thermally injured MRL/MPJ mice. Davis TA, Amare M, Naik S, Kovalchuk AL, Tadaki D. Wound Repair Regen. 2007;15(4):577–88. PubMed Europe PMC Scholia
  9. Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury. Bitto A, Galeano M, Squadrito F, Minutoli L, Polito F, Dye JF, et al. Crit Care Med. 2008 May;36(5):1594–602. PubMed Europe PMC Scholia
  10. Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy. Cameron AM, Turner CT, Adams DH, Jackson JE, Melville E, Arkell RM, et al. Br J Dermatol. 2016 Apr;174(4):786–94. PubMed Europe PMC Scholia
  11. NLRP3 inflammasome activity is required for wound healing after burns. Vinaik R, Abdullahi A, Barayan D, Jeschke MG. Transl Res. 2020 Mar;217:47–60. PubMed Europe PMC Scholia