Vitamins A and D - action mechanisms (WP4342)

Homo sapiens

The active forms of vitamins A and D both activate nuclear receptors. The generation of the vitamin metabolites and their role in the activation of the nuclear receptors is shown in the pathway.


Susan Coort , Kristina Hanspers , and Alex Pico


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Homo sapiens



Pathway Ontology

vitamin D metabolic pathway vitamin D signaling pathway vitamin A and metabolites signaling pathway


Label Type Compact URI Comment
beta-carotene Metabolite chebi:17579
7-Dehydrocholesterol Metabolite hmdb:HMDB0000032
retinol (vit A) Metabolite chebi:17336
retinal Metabolite chebi:15035
ATRA Metabolite chebi:50648
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
25(OH)D3 Metabolite chebi:17933
Vitamin D3 Metabolite chebi:28940
Previtamin D3 Metabolite hmdb:HMDB0006500
1,25(OH)2D3 Metabolite hmdb:HMDB0000969
25(OH)D3 Metabolite chebi:17933
1,25(OH)2D3 Metabolite hmdb:HMDB0000969
VDR GeneProduct ensembl:ENSG00000111424
RXR GeneProduct ensembl:ENSG00000186350
RXR GeneProduct ensembl:ENSG00000131759
RXR GeneProduct ensembl:ENSG00000186350
RAR GeneProduct ensembl:ENSG00000131759
RXR GeneProduct ensembl:ENSG00000186350


  1. Vitamin effects on the immune system: vitamins A and D take centre stage. Mora JR, Iwata M, von Andrian UH. Nat Rev Immunol. 2008 Sep;8(9):685–98. PubMed Europe PMC Scholia