Oxidative damage response (WP3941)
Homo sapiens
This pathway shows how tissue is damaged when oxygen levels are not balanced and become too high. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3941 CPTAC Assay Portal]
Authors
Kristina Hanspers , Eric Weitz , and Egon WillighagenActivity
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Cited In
- Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
- Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
oxidative stress response pathway oxidative stress response pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PCNA | GeneProduct | ensembl:ENSG00000132646 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18538 |
| C1QC | GeneProduct | ensembl:ENSG00000159189 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12262 |
| CDKN1C | GeneProduct | ensembl:ENSG00000129757 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12577 |
| C1QB | GeneProduct | ensembl:ENSG00000173369 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12260 |
| C5AR1 | GeneProduct | ensembl:ENSG00000197405 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12273 |
| TNFRSF1B | GeneProduct | ensembl:ENSG00000028137 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21938 |
| C5 | GeneProduct | ensembl:ENSG00000106804 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15139 |
| TRAF3 | GeneProduct | ensembl:ENSG00000131323 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22031 |
| BCL2 | GeneProduct | ensembl:ENSG00000171791 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12043 |
| CR2 | GeneProduct | ensembl:ENSG00000117322 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12902 |
| BAD | GeneProduct | ensembl:ENSG00000002330 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015 |
| APAF1 | GeneProduct | ensembl:ENSG00000120868 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11783 |
| MAP3K9 | GeneProduct | ensembl:ENSG00000006432 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:338372 |
| MAPK13 | GeneProduct | ensembl:ENSG00000156711 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26415 |
| CDC42 | GeneProduct | ensembl:ENSG00000070831 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12540 |
| TRAF2 | GeneProduct | ensembl:ENSG00000127191 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22030 |
| C4B | GeneProduct | ensembl:ENSG00000224389 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12268 |
| CDKN1A | GeneProduct | ensembl:ENSG00000124762 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575 |
| C1S | GeneProduct | ensembl:ENSG00000182326 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50908 |
| C1R | GeneProduct | ensembl:ENSG00000159403 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50909 |
| TDP2 | GeneProduct | ensembl:ENSG00000111802 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56196 |
| CYCS | GeneProduct | ensembl:ENSG00000172115 | Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13063 |
| TNK2 | GeneProduct | ensembl:ENSG00000061938 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51789 |
| C3AR1 | GeneProduct | ensembl:ENSG00000171860 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12267 |
| MAP2K4 | GeneProduct | ensembl:ENSG00000065559 | Xbp1,Mapk10,Klhl8,Mapk10Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26398 |
| BAG4 | GeneProduct | ensembl:ENSG00000156735 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67384 |
| C2 | GeneProduct | ensembl:ENSG00000166278 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12263 |
| CDKN1B | GeneProduct | ensembl:ENSG00000111276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12576 |
| TRAF1 | GeneProduct | ensembl:ENSG00000056558 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22029 |
| NFKBIE | GeneProduct | ensembl:ENSG00000146232 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18037 |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18033 |
| TNF | GeneProduct | ensembl:ENSG00000232810 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21926 |
| GADD45A | GeneProduct | ensembl:ENSG00000116717 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13197 |
| MAP3K1 | GeneProduct | ensembl:ENSG00000095015 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26401 |
| MAPK10 | GeneProduct | ensembl:ENSG00000109339 | Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414 |
| TRAF6 | GeneProduct | ensembl:ENSG00000175104 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22034 |
| C1QA | GeneProduct | ensembl:ENSG00000173372 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12259 |
| CASP3 | GeneProduct | ensembl:ENSG00000164305 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12367 |
| BAK1 | GeneProduct | ensembl:ENSG00000030110 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12018 |
| CASP9 | GeneProduct | ensembl:ENSG00000132906 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371 |