DNA repair pathways, full network (WP4946)

Homo sapiens

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DNA Repair Pathways Full Network

Authors

Xin Ding , Ernesto Diaz-Flores , Egon Willighagen , Marvin Martens , Denise Slenter , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

DNA repair pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATM GeneProduct ensembl:ENSG00000149311
ATR GeneProduct ensembl:ENSG00000175054
RPA1 GeneProduct ensembl:ENSG00000132383
RPA2 GeneProduct ensembl:ENSG00000117748
RPA3 GeneProduct ensembl:ENSG00000106399
RFC1 GeneProduct ensembl:ENSG00000035928
MSH2 GeneProduct ensembl:ENSG00000095002
MSH3 GeneProduct ensembl:ENSG00000113318
MSH6 GeneProduct ensembl:ENSG00000116062
RFC2 GeneProduct ensembl:ENSG00000049541
RFC3 GeneProduct ensembl:ENSG00000133119
RFC4 GeneProduct ensembl:ENSG00000163918
RFC5 GeneProduct ensembl:ENSG00000111445
EXO1 GeneProduct ensembl:ENSG00000174371
PCNA GeneProduct ensembl:ENSG00000132646
MLH1 GeneProduct ensembl:ENSG00000076242
PMS2 GeneProduct ensembl:ENSG00000122512
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
LIG1 GeneProduct ensembl:ENSG00000105486
RBX1 GeneProduct ensembl:ENSG00000100387
DDB1 GeneProduct ensembl:ENSG00000167986
DDB2 GeneProduct ensembl:ENSG00000134574
CUL4A GeneProduct ensembl:ENSG00000139842
CUL4B GeneProduct ensembl:ENSG00000158290
XPC GeneProduct ensembl:ENSG00000154767
XPA GeneProduct ensembl:ENSG00000136936
RAD23A GeneProduct ensembl:ENSG00000179262
RAD23B GeneProduct ensembl:ENSG00000119318
CETN2 GeneProduct ensembl:ENSG00000147400
ERCC1 GeneProduct ensembl:ENSG00000012061
ERCC2 GeneProduct ensembl:ENSG00000104884
ERCC3 GeneProduct ensembl:ENSG00000163161
ERCC4 GeneProduct ensembl:ENSG00000175595
ERCC5 GeneProduct ensembl:ENSG00000134899
ERCC6 GeneProduct ensembl:ENSG00000225830
ERCC8 GeneProduct ensembl:ENSG00000049167
CDK7 GeneProduct ensembl:ENSG00000134058
MNAT1 GeneProduct ensembl:ENSG00000020426
CCNH GeneProduct ensembl:ENSG00000134480
GTF2H5 GeneProduct ensembl:ENSG00000272047
GTF2H2 GeneProduct ensembl:ENSG00000145736
GTF2H1 GeneProduct ensembl:ENSG00000110768
GTF2H3 GeneProduct ensembl:ENSG00000111358
GTF2H4 GeneProduct ensembl:ENSG00000213780
RPA1 GeneProduct ensembl:ENSG00000132383
RPA2 GeneProduct ensembl:ENSG00000117748
RPA3 GeneProduct ensembl:ENSG00000106399
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
PCNA GeneProduct ensembl:ENSG00000132646
RFC1 GeneProduct ensembl:ENSG00000035928
RFC2 GeneProduct ensembl:ENSG00000049541
RFC3 GeneProduct ensembl:ENSG00000133119
RFC4 GeneProduct ensembl:ENSG00000163918
RFC5 GeneProduct ensembl:ENSG00000111445
LIG1 GeneProduct ensembl:ENSG00000105486
XRCC4 GeneProduct ensembl:ENSG00000152422
XRCC5 GeneProduct ensembl:ENSG00000079246
XRCC6 GeneProduct ensembl:ENSG00000196419
WRN GeneProduct ensembl:ENSG00000165392
PRKDC GeneProduct ensembl:ENSG00000253729
DCLRE1C GeneProduct ensembl:ENSG00000152457
POLM GeneProduct ensembl:ENSG00000122678
POLL GeneProduct ensembl:ENSG00000166169
LIG4 GeneProduct ensembl:ENSG00000174405
NHEJ1 GeneProduct ensembl:ENSG00000187736
OGG1 GeneProduct ensembl:ENSG00000114026
NTHL1 GeneProduct ensembl:ENSG00000065057
NEIL2 GeneProduct ensembl:ENSG00000154328
NEIL3 GeneProduct ensembl:ENSG00000109674
APEX1 GeneProduct ensembl:ENSG00000100823
APEX2 GeneProduct ensembl:ENSG00000169188
PNKP GeneProduct ensembl:ENSG00000039650
XRCC1 GeneProduct ensembl:ENSG00000073050
POLB GeneProduct ensembl:ENSG00000070501
POLL GeneProduct ensembl:ENSG00000166169
PARP1 GeneProduct ensembl:ENSG00000143799
PARP2 GeneProduct ensembl:ENSG00000129484
HMGB1 GeneProduct ensembl:ENSG00000189403
LIG1 GeneProduct ensembl:ENSG00000105486
LIG3 GeneProduct ensembl:ENSG00000005156
UNG GeneProduct ensembl:ENSG00000076248
SMUG1 GeneProduct ensembl:ENSG00000123415
MUTYH GeneProduct ensembl:ENSG00000132781
MPG GeneProduct ensembl:ENSG00000103152
MBD4 GeneProduct ensembl:ENSG00000129071
TDG GeneProduct ensembl:ENSG00000139372
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
PCNA GeneProduct ensembl:ENSG00000132646
POLE GeneProduct ensembl:ENSG00000177084
POLE2 GeneProduct ensembl:ENSG00000100479
POLE3 GeneProduct ensembl:ENSG00000148229
POLE4 GeneProduct ensembl:ENSG00000115350
FEN1 GeneProduct ensembl:ENSG00000168496
NBN GeneProduct ensembl:ENSG00000104320
MRE11A GeneProduct ensembl:ENSG00000020922
RPA1 GeneProduct ensembl:ENSG00000132383
BRCA2 GeneProduct ensembl:ENSG00000139618
RAD50 GeneProduct ensembl:ENSG00000113522
RAD51 GeneProduct ensembl:ENSG00000051180
RAD52 GeneProduct ensembl:ENSG00000002016
RAD54B GeneProduct ensembl:ENSG00000197275
POLD1 GeneProduct ensembl:ENSG00000062822
POLD2 GeneProduct ensembl:ENSG00000106628
POLD3 GeneProduct ensembl:ENSG00000077514
POLD4 GeneProduct ensembl:ENSG00000175482
FANCA GeneProduct ensembl:ENSG00000187741
FANCD2 GeneProduct ensembl:ENSG00000144554
FANCC GeneProduct ensembl:ENSG00000158169
FANCN GeneProduct ensembl:ENSG00000083093 PALB2
FANCM GeneProduct ensembl:ENSG00000187790
FANCL GeneProduct ensembl:ENSG00000115392
FANCJ GeneProduct ensembl:ENSG00000136492 BRIP1
FANCI GeneProduct ensembl:ENSG00000140525
FANCG GeneProduct ensembl:ENSG00000221829
FANCF GeneProduct ensembl:ENSG00000183161
FANCE GeneProduct ensembl:ENSG00000112039
FANCB GeneProduct ensembl:ENSG00000181544
FAAP24 GeneProduct ensembl:ENSG00000131944
FAAP100 GeneProduct ensembl:ENSG00000185504
MHF1 GeneProduct ensembl:ENSG00000175279 CENPS
MHF2 GeneProduct ensembl:ENSG00000169689 CENPX
FAN1 GeneProduct ensembl:ENSG00000198690
USP1 GeneProduct ensembl:ENSG00000162607
UAF1 GeneProduct ensembl:ENSG00000114742 WDR48
ATR GeneProduct ensembl:ENSG00000175054
CHEK1 GeneProduct ensembl:ENSG00000149554
H2AX GeneProduct ensembl:ENSG00000188486
BRCA1 GeneProduct ensembl:ENSG00000012048
BRCA2 GeneProduct ensembl:ENSG00000139618
RAD51C GeneProduct ensembl:ENSG00000108384
LIG4 GeneProduct ensembl:ENSG00000174405
LIG1 GeneProduct ensembl:ENSG00000105486
XRCC4 GeneProduct ensembl:ENSG00000152422
XRCC5 GeneProduct ensembl:ENSG00000079246
XRCC6 GeneProduct ensembl:ENSG00000196419
PRKDC GeneProduct ensembl:ENSG00000253729
MRE11 GeneProduct ensembl:ENSG00000020922
RAD50 GeneProduct ensembl:ENSG00000113522
TERF2 GeneProduct ensembl:ENSG00000132604
RAP1A GeneProduct ensembl:ENSG00000116473
ATM GeneProduct ensembl:ENSG00000149311
ATR GeneProduct ensembl:ENSG00000175054
REV3L GeneProduct ensembl:ENSG00000009413
REV1 GeneProduct ensembl:ENSG00000135945
POLH GeneProduct ensembl:ENSG00000170734
POLI GeneProduct ensembl:ENSG00000101751
POLK GeneProduct ensembl:ENSG00000122008
PCNA GeneProduct ensembl:ENSG00000132646
MGMT GeneProduct ensembl:ENSG00000170430

References

  1. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Kee Y, D’Andrea AD. Genes Dev. 2010 Aug 15;24(16):1680–94. PubMed Europe PMC Scholia
  2. Alternative end-joining mechanisms: a historical perspective. Decottignies A. Front Genet. 2013 Apr 2;4:48. PubMed Europe PMC Scholia
  3. Translesion DNA polymerases. Goodman MF, Woodgate R. Cold Spring Harb Perspect Biol. 2013 Oct 1;5(10):a010363. PubMed Europe PMC Scholia
  4. Targeting DNA repair in cancer: current state and novel approaches. Klinakis A, Karagiannis D, Rampias T. Cell Mol Life Sci. 2020 Feb;77(4):677–703. PubMed Europe PMC Scholia
  5. Advances in DNA Repair-Emerging Players in the Arena of Eukaryotic DNA Repair. Kciuk M, Bukowski K, Marciniak B, Kontek R. Int J Mol Sci. 2020 May 30;21(11):3934. PubMed Europe PMC Scholia