Orexin receptor pathway (WP5094)

Homo sapiens

Orexin-stimulated reactions involving signal transduction mechanisms and downstream effectors associated with varied physiological outcomes

Authors

Dr. T. S. Keshava Prasad , Egon Willighagen , Eric Weitz , Kristina Hanspers , and Aishwarya Iyer

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

neurotransmitter metabolic pathway signaling pathway pertinent to the brain and nervous system signaling pathway

Participants

Label Type Compact URI Comment
2-AG Metabolite kegg.compound:C13856
Glucose Metabolite kegg.compound:C00031
Cortisol Metabolite kegg.compound:C00735
Triglyceride Metabolite kegg.compound:C00422
cAMP Metabolite kegg.compound:C00575
IP3 Metabolite chebi:16595
Ca2+ Metabolite kegg.compound:C00076
DAG Metabolite chebi:88376
PIP2 Metabolite hmdb:HMDB0010032
PIP3 Metabolite chebi:16618
Ca2+ Metabolite kegg.compound:C00076
Glycerol Metabolite kegg.compound:C00116
Testosterone Metabolite kegg.compound:C00535
Cytochrome C Metabolite kegg.compound:C00125
Cytochrome C Metabolite kegg.compound:C00125
IP2 Metabolite chebi:18156
Progesterone Metabolite kegg.compound:C00410
Epinephrine Metabolite kegg.compound:C00788
2-AG Metabolite kegg.compound:C13856
Glutamicacid uptake Metabolite kegg.compound:C00025
Glutamic acid Metabolite kegg.compound:C00025
Ca2+ Metabolite kegg.compound:C00076
Ca2+ Metabolite kegg.compound:C00076
Ca2+ Metabolite kegg.compound:C00076
Ca2+ Metabolite kegg.compound:C00076
Ca2+ Metabolite kegg.compound:C00076
Ca2+ Metabolite kegg.compound:C00076
Ca2+ Metabolite kegg.compound:C00076
Glucose Metabolite kegg.compound:C00031
PA Metabolite kegg.compound:C00416
AA Metabolite kegg.compound:C00219
PIK3R1 GeneProduct ncbigene:5295
HCRTR1 GeneProduct ncbigene:3061
HCRTR2 GeneProduct ncbigene:3062
GNAS GeneProduct refseq:NP_536350 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAS in human adult adrenals.
GNAI1 GeneProduct refseq:NP_002060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
HCRTR2 GeneProduct ncbigene:3062 [Pubmed:19793950] have shown that Ox-A stimulates HCRTR2 and induces downregulation of HCRTR2 mRNA within 6 hours of treatment on H295R adrenal cells.
HCRTR1 GeneProduct ncbigene:3061 [Pubmed:24333629] have shown that Ox-A/Ox-B stimulates HCRTR1/HCRTR2 and induces downregulation of HCRTR1 mRNA in rat anterior pituitary cells.
HCRTR2 GeneProduct ncbigene:3062 [Pubmed:24333629] have shown that Ox-A/B stimulates HCRTR2 and induces upregulation of HCRTR2 mRNA in rat anterior pituitary cells.
HCRTR1 GeneProduct ncbigene:3061
HCRTR1 GeneProduct ncbigene:3061
CNR1 GeneProduct ncbigene:3062
CASP3 GeneProduct ncbigene:836
HIF1A GeneProduct ncbigene:3091 [Pubmed:21239965] have shown that Ox-A stimulates HCRTR1 and induces upregulation of HIF1A protein in rat hippocampal neurons.
VHL GeneProduct ncbigene:7428 [Pubmed:18006690] have shown that Ox-A stimulates HCRTR1 and induces downregulation of VHL protein in HEK293 cells and rat hypothalamus.
HIF1A GeneProduct ncbigene:3091 [Pubmed:18006690] have shown that Ox-A stimulates HCRTR1 and induces activation of HIF1A in HEK293 cells and rat hypothalamus.
[Pubmed:28886081] have shown that Ox-A stimulates HCRTR1 and induces translocation of HIF1A from cytoplasm to nucleus in HepG2 cells.
PTPN11 GeneProduct ncbigene:5781 [Pubmed:19661287] have shown that Ox-A stimulates HCRTR1 and induces activation of PTPN11 in CHO-OX1 cells.
[Pubmed:18198212] have shown that Ox-A stimulates HCRTR1 and induces molecular association of HCRTR1 and PTPN11 in CHO-hOX1R cells.
HCRTR2 GeneProduct ncbigene:3062
HCRTR2 GeneProduct ncbigene:3062
PIK3R2 GeneProduct ncbigene:5296
HCRTR1 GeneProduct ncbigene:3061 [Pubmed:26459696] have shown that Ox-A stimulates HCRTR1 and induces upregulation of HCRTR1 mRNA in H295R adrenocorticoid cells.
HCRTR1 GeneProduct ncbigene:3061 [Pubmed:26220343] have shown that Ox-A stimulates HCRTR1 and induces upregulation of HCRTR1 mRNA in LNCaP cells.
SLC2A1 GeneProduct ncbigene:6513 [Pumed:26549689] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SLC2A1 protein in a PI3K-AKT-MTRO dependent manner in Hep3B cells.
SLC2A1 GeneProduct ncbigene:6513 [Pumed:26549689] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SLC2A1 protein in a PI3K-AKT-MTRO dependent manner in Hep3B cells.
PRKCA GeneProduct ncbigene:5578 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of PRKCA protein in astrocytes of Neonatal Sprague-Dwaley rats.
MAPK1 GeneProduct ncbigene:5594 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of MAPK1 protein in astrocytes of Neonatal Sprague-Dwaley rats.
MAPK3 GeneProduct ncbigene:5595 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of MAPK3 protein in astrocytes of Neonatal Sprague-Dwaley rats.
SLC1A2 GeneProduct ncbigene:6506 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of SLC1A2 protein in astrocytes of Neonatal Sprague-Dwaley rats.
SLC1A2 GeneProduct ncbigene:6506 [Pubmed: 27837432] have shown that Orexin-A stimulates OX1R and induces an upregulation of SLC1A2 protein in astrocytes of Neonatal Sprague-Dwaley rats.
MAPK9 Protein refseq:NP_002743 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK9 in 3T3-L1 adipocytes.
[Pubmed: 16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK9 at Thr183 in CHO-OX1R cells
[Pubmed:25857454] have shown that Ox-a stimualtes HCRTR1 and induces phosphorylation of MAPK9 at Thr183 in a GNAQ dependent manner in CHO cells.
MAPK3 Protein refseq:NP_002737 [Pubmed:15683363] have shown that OxA stimulates HCRTR1 and induces phosphorylation of MAPK3 at Thr202 and Tyr204 in MEK cells.
MAP2K2 Protein refseq:NP_109587 [Pubmed:25278019] have shown that Ox-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of MAP2K2 at Ser216 and Ser222 under influence of calcium influx in N41 neuronal cells.
NPFFR1 Protein ncbigene:64106 [Pubmed:31091547] have shown that Ox-A stimulate HCRTR1/2 and induce upregulation of NPFFR1 mRNA in rat brain.
OPRK1 Protein ncbigene:4986
MAPK8 Protein ncbiprotein:NP_620637.1 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK8 in 3T3-L1 adipocytes.
[Pubmed: 16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK8 at Thr183 in CHO-OX1R cells
[Pubmed:25857454] have shown that Ox-a stimualtes HCRTR1 and induces phosphorylation of MAPK8 at Thr183 in a GNAQ dependent manner in CHO cells.
MAPK14 Protein refseq:NP_001306 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK14 in 3T3-L1 adipocytes.
[Pubmed:16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK14 at Thr180 and Tyr182 in CHO-OX1 cells.
MAPK1 Protein refseq:NP_002736 [Pubmed:15683363] have shown that OxA stimulates HCRTR1 and induces phosphorylation of MAPK1 at Thr183 and Tyr185 in MEK cells.
CREB1 Protein refseq:NP_604391 [Pubmed:22652455] have shown that Ox-B stimulates HCRTR2 and induces phosphorylation of CREB1 at Ser133 in a PKC dependent manner in CHO-OXR2 cells.
PDPK1 Protein refseq:NP_001248745 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
AKT1 Protein ncbiprotein:NP_005154.2 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of AKT1 at Ser473 in InR1-G9 cell line
[Pubmed:26459696] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of AKT1 at Ser473 in a PI3K dependent manner in H295R adrenocorticoid cells
FOXO1 Protein refseq:NP_002006 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of FOXO1 at Ser256 in InR1-G9 cell line.
PI3KCatalytic Protein refseq:NP_001265478 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
MAP2K1 Protein refseq:NP_002746 [Pubmed:25278019] have shown that Ox-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of MAP2K1 at Ser218 and Ser222 under influence of calcium influx in N41 neuronal cells.
GNAQ Protein refseq:NP_002063 [Pubmed:25857454] have shown that Ox-A stimulates HCRTR1 and induces activation of GNAQ in CHO cells.
[Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAQ in human adult adrenals.
PKA Protein ncbigene:5578 [Pubmed:18488139] have shown that Ox-A stimulates HCRTR1 and induces the translocation of PRKCA from cytosol to plasma membrane in CHO cell lines.
STAR Protein ncbigene:6770 [Pubmed: 18450961]have shown that Ox-A or Ox-B stimulates HCRTR1 and induces the upregulation of STAR protein mediated through ERK1/2 dependent and p38 dependent MAPK cascades in human H295R adrenal cells.
STAR Protein ncbigene:6770 [Pubmed:18450961]have shown that Ox-A or Ox-B stimulates HCRTR1 and induces upregulation of STAR mRNA through MAPK cascades in human H295R adrenocortical cells.
[Pubmed:19460850] have shown that Ox-A or Ox-B stimulates HCRTR1 and induces upregulation of STAR mRNA in H295R adernocortical cells.
BGLAP Protein refseq:NP_954642 [Pubmed:19020772] have shown that Ox-B stimulates HCRTR1 and induces upregulation of BGLAP protein in rat calvarial osteoblast-like cells.
CGA Protein ncbigene:1081 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
LHB Protein ncbigene:3972 [Pubmed:24333629] have shown that Ox-A/B stimulate HCRTR1/2 and induces upregulation of LHB in rat anterior pituitary cells.
CGA Protein ncbigene:1081 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
FSHB Protein ncbigene:2488 [Pubmed:24333629] have shown that Ox-A/B stimulate HCRTR1/2 and induces upregulation of FSHB in rat anterior pituitary cells.
MAPK7 Protein refseq:NP_620602 [Pubmed:19460850] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK7 at Thr218 and Tyr220 in H295R(Human) adrenocortical cells.
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed:21378163] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and ARRB1 in HEK293T cells.
HCRTR1 Protein ncbigene:3061 [Pubmed:19661287] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of HCRTR1 at Tyr83 and Tyr358 in CHO-OX1 cells.
ARRB1 Protein refseq:NP_004032 [Pubmed:11299310] have shown that Ox-A stimulates HCRTR1 and induces translocation of HCRTR1-ARRB1 complex from plasma membrane to endosome in CHO cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:21378163] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and ARRB2 in HEK293T cells.
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed:21378163] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and ARRB1 in HEK293T cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB2 in HEK293 cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:15683363] have shown that OxA stimulates HCRTR1 and induces translocation of HCRTR1-ARRB2 complex from plasma membrane to acidic endosomes in HEK293 cells.
L-typeCalciumchannels Protein refseq:NP_001265478 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
TH Protein refseq:NP_954986 [Pubmed:23635422] have shown that Ox-A/B stimulate HCRTR1/2 and induce phosphorylation of TH at Ser40 in bovine adrenal medulla cells.
Voltage-gatedCa2+ and Na+channels Protein refseq:NP_001265478 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PDK1 at Ser241 in InR1-G9 cell line.
CCK Protein ncbigene:2688 [Pubmed:12943684] have shown that Ox-A stimulates HCRTR1 and HCRTR2 and induces the upregulation of CCK in STC1 cells.
CCK Protein ncbigene:885 [Pubmed:12943684] have shown that Ox-A stimulates HCRTR1 and HCRTR2 and induces the upregulation of CCK in STC1 cells
GH1 Protein ncbigene:2688 [Pubmed:14610299] have shown that Ox-B stimulates HCRTR2 and induces upregulation of GH1 protein in ovine somatotropes.
CASP7 Protein refseq:NP_620637 [Pubmed:23907013] have shown that Ox-a stimulates HCRTR1 and induces phosphorylation of MAPK8 in 3T3-L1 adipocytes.
[Pubmed: 16282319] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK8 at Thr183 in CHO-OX1R cells
[Pubmed:15310763] have shown that Ox-A/B stimulates HCRTR1 and induces activation of CASP7 in HT29-D4 cells.
PLCD1 Protein ncbigene:5333 [Pubmed:16141359] have shown that Ox-A stimulates HCRTR1 and induces the translocation of PLCD1 from plasma membrane to cytoplasm in CHO cells.
PRKCE Protein ncbigene:5581 [Pubmed:16141359] have shown that Ox-A stimulates HCRTR1 and induces the translocation of PRKCE from plasma membrane to cytosol in CHO cell lines.
PRKCZ Protein ncbigene:5590
GCG Protein ncbigene:2641 [Pubmed:18162514] have shown that Ox-A stimulates HCRTR1 and induces downregulation of GCG protein in InR-G9 cells.
PRKCA Protein ncbigene:5578 [Pubmed:20621130] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKCA at Thr638 in HEK OX1R cells.
GRIA1 Protein ncbigene:2890 [Pubmed: 19028455] have shown that Ox-A stimulates HCRTR1 and induces upregulation of GRIA1 protein in rat prefrontal cortex-striatum coculture.
PRKCD Protein ncbigene:5580 [Pubmed:20621130] have shown that OX-A stimulates HCRTR1 and induces phosphorylation of PRKCD at Thr505 in HEKOX1R cells.
PRKCB Protein ncbigene:5579 [Pubmed:20621130] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKCB at Thr641 in HEK OX1R cells.
PRKD1 Protein refseq:NP_001316998 [Pubmed:20621130] have shown that OX-A stimulates HCRTR1 and induces phosphorylation of PRKD1 at Ser916 in HEKOX1R cells.
PRKD3 Protein ncbiprotein:NP_005804.1 [Pubmed:20621130] have shown that OX-A stimulates HCRTR1 and induces phosphorylation of PRKD3 at Ser744/748 in HEKOX1R cells.
ARRB1 Protein refseq:NP_004032 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB1 in HEK293 cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB2 in HEK293 cells.
ARRB2 Protein refseq:NP_001244257 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB2 in HEK293 cells.
ARRB1 Protein refseq:NP_004032 [Pubmed:28487995] have shown that Ox-A/Ox-B stimulate HCRTR2 and induce molecular association of HCRTR2 and ARRB1 in HEK293 cells.
SLC2A4 Protein ncbigene:6517 [Pubmed:23907013] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SLC2A4 mRNA in 3T3-L1 adipocytes.
ADIPOQ Protein ncbigene:9370 [Pubmed:21505958] have shown that Ox-A stimulates HCRTR1/HCRTR2 and induces upregulation of ADIPOQ protein in a PPARG dependent manner in 3T3-L1 adipocytes and primary adipocytes from wistar rats.
PLD1 Protein ncbigene:5337 [Pubmed:21718304] have shown that Ox-A stimulates HCRTR1 and induces activation of PLD1 in a PRKCD dependent manner in CHO-OxR1 cells.
BMP7 Protein ncbigene:655 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces upregulation of BMP7 mRNA in C3H10T1/2 cells.
BMPR1A Protein ncbigene:657 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces upregulation of BMPR1A mRNA in C3H10T1/2 cells.
SMAD1 Protein refseq:NP_001341740 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of SMAD1 at Ser463 downstream of BMPR1A in C3H10T1/2 cells.
SMAD5 Protein refseq:NP_001001419 [Pubmed:21982708] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of SMAD5 at Ser465 downstream of BMPR1A in C3H10T1/2 cells.
DYNLT1 Protein refseq:NP_006510 [Pubmed:22028875] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and DYNLT1 in HEK293 cells.
DYNLT3 Protein ncbigene:6990 [Pubmed:22028875] have shown that Ox-A stimulates HCRTR1 and induces molecular association between HCRTR1 and DYNLT1 in HEK293 cells.
PRKAA1 Protein refseq:NP_996790 [Pubmed:24068427] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKAA1 at Thr172 in a Camkkbeta-Calcium dependent manner in rat hypothalamic nuclear neurons.
CAMKK2 Protein ncbigene:10645 [Pubmed:24068427] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKAA1 at Thr172 in a Camkkbeta-Calcium dependent manner in rat hypothalamic nuclear neurons.
NPY Protein ncbigene:4852 [Pubmed:24068427] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of PRKAA1 at Thr172 in a Camkkbeta-Calcium dependent manner in rat hypothalamic nuclear neurons.
GHRL Protein ncbigene:51738 [Pubmed:24794976] have shown that Ox-A stimulates HCRTR1 and induces downregulation of GHRL protein in mouse osteoblast and adipocyte.
LEP Protein ncbigene:3952 [Pubmed:24794976] have shown that Ox-A stimulates HCRTR1 and induces downregulation of LEP protein in mouse serum.
MTOR Protein ncbiprotein:NP_004949.1 [Pubmed:24807827] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MTOR at Ser2481 in a PI3K-AKT dependent manner in rat hepatocytes.
RPS6 Protein refseq:NP_001001 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of RPS6 on Ser235/236 and Ser240/244 under the lysosome v-ATPase-RAG-GTPase pathway activating MTORC1 in HEK293T and N41 neural cells.
RPS6KB1 Protein refseq:NP_003152 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of RPS6KB1 on Thr389 under the lysosome v-ATPase-RAG-GTPase pathway activating MTORC1 in HEK293T and N41 neural cells.
EIF4B Protein refseq:NP_001287750 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of EIF4B on Ser422 under the lysosome v-ATPase-RAG-GTPase pathway activating MTORC1 in HEK293T and N41 neural cells.
RPS6KA1 Protein refseq:NP_002944 [Pubmed:25278019] have shown that Ox-A/B stimulates HCRTR1 and/or HCRTR2 and induces phosphorylation of RPS6KA1 at Ser380 in a MEK1/2 dependent manner under influence of calcium influx in N41 neuronal cells.
MTOR Protein ncbigene:2475 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces activation of MTOR in HEK293T and N41 neural cells.
RRAGC Protein ncbigene:64121 [Pubmed:25278019] have shown that OX-A/B stimulates HCRTR1 and/or HCRTR2 and induces activation of RRAGC in HEK293T and N41 neural cells.
DAGLA Protein ncbigene:747 [Pubmed:33613258] have shown that Ox-A stimulates HCRTR1 and induces activation of DAGLA in TH positive neurons in mice.
CASP9 Protein refseq:NP_001220 [Pubmed:25515760] have shown that Ox-A stimulates HCRTR1 and induces inhibition of CASP9 in a MAPK1/3 dependent manner in SGC-7901 cells.
EIF4EBP1 Protein refseq:NP_004086 [Pubmed:26064108] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of EIF4EBP1 at Thr37 and Thr46 in a MTOR mediated manner in H295R cells.
NFE2L2 Protein ncbigene:4780 [Pubmed:26170736] have shown that Ox-A stimulates HCRTR1/2 and induces upregulation of NFE2L2 protein in HUVECs.
NFE2L2 Protein ncbigene:4780 [Pubmed:26170736] have shown that Ox-A stimulates HCRTR1/2 and induces upregulation of NFE2L2 protein in HUVECs.
[Pubmed:26170736] have shown that Ox-A stimulates HCRTR1/2 and induces activation of NFE2L2 in HUVECs.
CASP3 Protein ncbiprotein:NP_620637.1 [Pubmed:24382962] have shown that Ox-A stimulates HCRTR1 and induces inhibition of CASP3 in a PI3K-AKT dependent pathway in INS1 cells.
MAPK3 Protein ncbiprotein:NP_002737.2 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK3 at Thr202 and Tyr204 in mouse POMC neurons.
MAPK1 Protein refseq:NP_002736 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of MAPK1 at Thr185 and Tyr187 in mouse POMC neurons.
STAT3 Protein refseq:NP_001356441 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces phosphorylation of STAT3 at Ser727 downstream of MAPK1/3 in mouse POMC neurons.
POMC Protein ncbigene:5443 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces downregulation of POMC mRNA in a MAPK1/3-STAT3 dependent manner in mouse POMC cells.
POMC Protein ncbiprotein:5443 [Pubmed:27071101] have shown that Ox-A stimulates HCRTR1 and induces downregulation of POMC protein in a MAPK1/3-STAT3 dependent manner in mouse POMC cells.
GNA11 Protein ncbigene:2767 [Pubmed:27237973] have shown that Ox-A/B stimulates HCRTR1 and induces molecular association of HCRTR1 and GNA11 in CHO-K1 cells.
PDHB Protein ncbigene:5162 [Pubmed:26549689] have shown that OX-A stimulates HCRTR1 and induces upregulation of PDHB mRNA in Hep3B cells.
SGK1 Protein ncbigene:6446 [Pubmed:29145494] have shown that Ox-A stimulates HCRTR1 and induces upregulation of SGK1 mRNA in GT1-7 cells.
HCRT Protein ncbigene:3060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
HCRT Protein ncbigene:3060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
HCRT Protein ncbigene:3060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
HCRT Protein ncbigene:3060 [Pubmed:11600545] have shown that Ox-A stimulates HCRTR2 and induces molecular association of HCRTR2 and GNAI1 in human adult adrenals.
RUNX2 Protein ncbigene:860 [Pubmed:29999239] have shown that Ox-A stimulates HCRTR1 and induces upregulation of RUNX2 protein in a PKD/MAPK14 dependent manner in MC3T3-E1 cells.
COX2 Protein ncbigene:6775079 [Pubmed:18378017] have shown that Ox-A stimulates HCRTR1 and induces upregulation of COX2 protein in rat gastric mucosa.
GNRH1 Protein ncbigene:2796 [Pubmed:31091547] have shown that Ox-A stimulates HCRTR1 and induces downregulation of GNRH1 mRNA in rats.
NPVF Protein ncbigene:64111 [Pubmed:31091547] have shown that Ox-A stimulate HCRTR1/2 and induce upregulation of NVPF mRNA in rat brain.
IL6 Protein ncbigene:3569 [Pubmed:30142537] have shown that Ox-A stimulates HCRTR1 and induces downregulation of IL6 protein in TNF alpha treated fibroblast-like synoviocytes.
CXCL8 Protein ncbigene:3576 [Pubmed:30142537] have shown that Ox-A stimulates HCRTR1 and induces downregulation of CXCL8 protein in TNF alpha treated fibroblast-like synoviocytes.
TNF Protein ncbigene:7124 [Pubmed:31106596] have shown that Ox-A stimulates HCRTR1 and induces downregulation of TNF protein in HBx transfected L-02 and MIHA hepatocytes.
IL1B Protein ncbigene:3553 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces downregulation of IL1B protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
IL9 Protein ncbigene:3578 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces downregulation of IL9 protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
IL4 Protein ncbigene:3565 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces upregulation of IL4 protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
IL10 Protein ncbigene:3586 [Pubmed:32539736] have shown that Ox-A stimulates HCRTR2 and induces upregulation of IL10 protein in a CAMKK2/PRKAA mediated manner in intacerebral hemorrhagic mouse brain.
NOX4 Protein ncbigene:50507 [Pubmed:31106596] have shown that Ox-A stimulates HCRTR1 and induces downregulation of NOX4 protein in HBx transfected L-02 and MIHA hepatocytes.
CXCL2 Protein ncbigene:2920 [Pubmed:31106596] have shown that Ox-A stimulates HCRTR1 and induces downregulation of CXCL2 protein in HBx transfected L-02 and MIHA hepatocytes.
PLA2G4A Protein ncbiprotein:5321

References

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  2. Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. Mazzocchi G, Malendowicz LK, Gottardo L, Aragona F, Nussdorfer GG. J Clin Endocrinol Metab. 2001 Feb;86(2):778–82. PubMed Europe PMC Scholia
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