STING pathway in Kawasaki-like disease and COVID-19 (WP4961)

Homo sapiens

Triggering of the STING pathway by foreign DNA or damaged mitochondrial DNA can activate multiple downstream responses. The STING pathway is relevant to Kawasaki-like disease in COVID-19.

Authors

Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

COVID-19 Kawasaki disease

Pathway Ontology

pattern recognition receptor mediated signaling pathway

Participants

Label Type Compact URI Comment
Angiotensin II Metabolite chebi:2719
Aspirin Metabolite chebi:15365
Vitamin D3 Metabolite chebi:28940
cGAMP Metabolite chebi:71580
Cytokines GeneProduct wikidata:Q212354
Cytosolic DNA(viral DNA and damaged mtDNA) GeneProduct wikidata:Q7430
F3 GeneProduct ensembl:ENSG00000117525
CHUK GeneProduct ensembl:ENSG00000213341
IKBKE GeneProduct ensembl:ENSG00000263528
IL1B GeneProduct ensembl:ENSG00000125538
GSDMD GeneProduct ensembl:ENSG00000104518
IFNB1 GeneProduct ensembl:ENSG00000171855
ITPR1 GeneProduct ensembl:ENSG00000150995
FCGR2A GeneProduct ensembl:ENSG00000143226
NLRP3 GeneProduct ensembl:ENSG00000162711
TBK1 GeneProduct ensembl:ENSG00000183735
NLRX1 GeneProduct ensembl:ENSG00000160703
STING1 GeneProduct ensembl:ENSG00000184584
IRF3 GeneProduct ensembl:ENSG00000126456
IRF3 GeneProduct ensembl:ENSG00000126456
CGAS GeneProduct ensembl:ENSG00000164430
IKBKB GeneProduct ensembl:ENSG00000104365
IKBKG GeneProduct ensembl:ENSG00000269335 NEMO
RELA GeneProduct ensembl:ENSG00000173039 RelA
NFKBIA GeneProduct ensembl:ENSG00000100906
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIE GeneProduct ensembl:ENSG00000146232
RELA GeneProduct ensembl:ENSG00000173039 RelA
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIE GeneProduct ensembl:ENSG00000146232
RELA GeneProduct ensembl:ENSG00000173039 RelA
NFKBIA GeneProduct ensembl:ENSG00000100906
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIE GeneProduct ensembl:ENSG00000146232

References

  1. Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway? Berthelot JM, Drouet L, Lioté F. Emerg Microbes Infect. 2020 Dec;9(1):1514–22. PubMed Europe PMC Scholia