STING pathway in Kawasaki-like disease and COVID-19 (WP4961)

Homo sapiens

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Triggering of the STING pathway by foreign DNA or damaged mitochondrial DNA can activate multiple downstream responses. The STING pathway is relevant to Kawasaki-like disease in COVID-19.

Authors

Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Eric Weitz , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

disease pathway pattern recognition receptor mediated signaling pathway

Disease Ontology

Kawasaki disease COVID-19

Participants
Query Drugst.One

Label Type Compact URI Comment
Angiotensin II Metabolite chebi:2719
Aspirin Metabolite chebi:15365
Vitamin D3 Metabolite chebi:28940
cGAMP Metabolite chebi:71580
Cytokines GeneProduct wikidata:Q212354
Cytosolic DNA(viral DNA and damaged mtDNA) GeneProduct wikidata:Q7430
F3 GeneProduct ensembl:ENSG00000117525
CHUK GeneProduct ensembl:ENSG00000213341
IKBKE GeneProduct ensembl:ENSG00000263528
IL1B GeneProduct ensembl:ENSG00000125538
GSDMD GeneProduct ensembl:ENSG00000104518
IFNB1 GeneProduct ensembl:ENSG00000171855
ITPR1 GeneProduct ensembl:ENSG00000150995
FCGR2A GeneProduct ensembl:ENSG00000143226
NLRP3 GeneProduct ensembl:ENSG00000162711
TBK1 GeneProduct ensembl:ENSG00000183735
NLRX1 GeneProduct ensembl:ENSG00000160703
STING1 GeneProduct ensembl:ENSG00000184584
IRF3 GeneProduct ensembl:ENSG00000126456
IRF3 GeneProduct ensembl:ENSG00000126456
CGAS GeneProduct ensembl:ENSG00000164430
IKBKB GeneProduct ensembl:ENSG00000104365
IKBKG GeneProduct ensembl:ENSG00000269335 NEMO
RELA GeneProduct ensembl:ENSG00000173039 RelA
NFKBIA GeneProduct ensembl:ENSG00000100906
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIE GeneProduct ensembl:ENSG00000146232
RELA GeneProduct ensembl:ENSG00000173039 RelA
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIE GeneProduct ensembl:ENSG00000146232
RELA GeneProduct ensembl:ENSG00000173039 RelA
NFKBIA GeneProduct ensembl:ENSG00000100906
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIE GeneProduct ensembl:ENSG00000146232

References

  1. Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway? Berthelot JM, Drouet L, Lioté F. Emerg Microbes Infect. 2020 Dec;9(1):1514–22. PubMed Europe PMC Scholia