Resolvin E1 and resolvin D1 signaling decrease inflammation (WP5191)

Homo sapiens

Signaling pathway of resolvin for resolution of inflammation in polymorphonuclear neutrophils and acinar cells


Elisa Santarsiero , Denise Slenter , Egon Willighagen , Eric Weitz , and Lars Willighagen


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Homo sapiens



Pathway Ontology

lipid signaling pathway

Cell Type Ontology

mature neutrophil acinar cell


Label Type Compact URI Comment
RvE1 Metabolite chebi:81559
LTB4 Metabolite chebi:15647
ATP Metabolite chebi:30616
RvD1 Metabolite chebi:81564
cAMP Metabolite chebi:17489
LTB4R GeneProduct ensembl:ENSG00000213903
FPR2 GeneProduct ensembl:ENSG00000171049
PDK1 GeneProduct ensembl:ENSG00000152256
AKT1 GeneProduct ensembl:ENSG00000142208
AKT1 GeneProduct ensembl:ENSG00000142208
CMKLR1 GeneProduct ensembl:ENSG00000174600
ERK GeneProduct ncbigene:2048
ADCY1 Protein uniprot:ENSG00000164742
GRK1 Protein uniprot:Q15835
PIK3CG Protein uniprot:P48736
PI-3 kinase I Protein eccode:
PIK3CB Protein uniprot:P42338
PIK3CA Protein uniprot:P42336
PIK3CD Protein uniprot:O00329
mTORC2 Protein uniprot:P42345


  1. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN. J Immunol. 2007 Mar 15;178(6):3912–7. PubMed Europe PMC Scholia
  2. Understanding resolvin signaling pathways to improve oral health. Keinan D, Leigh NJ, Nelson JW, De Oleo L, Baker OJ. Int J Mol Sci. 2013 Mar 8;14(3):5501–18. PubMed Europe PMC Scholia