DNA replication (WP192)

Caenorhabditis elegans

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [[wikipedia:DNA_replication|Wikipedia]]


Kdahlquist , David Koren , Thomas Kelder , Egon Willighagen , Christine Chichester , Eric Weitz , Ulas Babayigit , Denise Slenter , and Lars Willighagen


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Caenorhabditis elegans



Pathway Ontology

DNA replication pathway


Label Type Compact URI Comment
dATP Metabolite chebi:16284
ADP Metabolite chebi:16761
dCTP Metabolite chebi:16311
ATP Metabolite chebi:15422
CTP Metabolite chebi:17677
UTP Metabolite chebi:15713
ATP Metabolite chebi:15422
ATP Metabolite chebi:15422
dGTP Metabolite chebi:16497
ADP Metabolite chebi:16761
dUTP Metabolite chebi:17625
ATP Metabolite chebi:15422
GTP Metabolite chebi:15996
mcm-7 GeneProduct ncbigene:178831
rfc-1 GeneProduct ncbigene:179967
F10C2.4 GeneProduct ncbigene:179652
F33H2.5 GeneProduct ncbigene:173368
pri-1 GeneProduct ncbigene:176358
F34D10.2 GeneProduct ncbigene:175481
orc-2 GeneProduct ncbigene:174676
Y47D3A.28 GeneProduct ncbigene:176562
div-1 GeneProduct ncbigene:176439
pri-2 GeneProduct ncbigene:173122
mcm-2 GeneProduct ncbigene:174841
mcm-6 GeneProduct ncbigene:176385
rfc-3 GeneProduct ncbigene:178259
cdc-6 GeneProduct ncbigene:172029
Y39A1A.12 GeneProduct ncbigene:176486
Y47D3A.29 GeneProduct ncbigene:176544
ubq-1 GeneProduct ncbigene:175840
mcm-3 GeneProduct ncbigene:180010
F08B4.5 GeneProduct ncbigene:177673
ARPA GeneProduct ncbigene:176131
ubq-2 GeneProduct ncbigene:176718
CDC46 GeneProduct ncbigene:175552
rfc-2 GeneProduct ncbigene:176946
mcm-4 GeneProduct ncbigene:171793


  1. Replication and repair. Rose A. WormBook [Internet]. 2014 Dec 4;1–16. Available from: http://dx.doi.org/10.1895/wormbook.1.54.2 DOI Scholia
  2. Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Brauchle M, Baumer K, Gönczy P. Curr Biol. 2003 May 13;13(10):819–27. PubMed Europe PMC Scholia