Proximal tubule transport (WP4917)

Homo sapiens

This pathway provides an overview of all active transport that occurs in the proximal tubule of the nephron in the kidneys. The proximal tubule plays roles in regulating the pH of the filtrate, secreting organic waste, and reabsorption of NaCl, a large variety of solutes, and amino acids from the filtrate back into the circulation. The apical side indicates the proximal tubule which contains the filtrate after passing through Bowman's capsule, which later becomes the urine after passing through the complete nephron, from which solutes are reabsorbed (taken back into the body) and into which waste is secreted. Impaired ability of reabsorption by the proximal tubule can lead to Fanconi syndrome.

Authors

Marvin Martens , Anna Baya Meuleman , Friederike Ehrhart , Finterly Hu , Eric Weitz , and Aishwarya Iyer

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

transport pathway

Cell Type Ontology

kidney cell epithelial cell of proximal tubule

Disease Ontology

Fanconi syndrome

Participants

Label Type Compact URI Comment
Cys Metabolite chebi:17376
organic anion Metabolite chebi:25696
organic cation Metabolite chebi:25697
Pro Metabolite chebi:26271
oxalate(2−) Metabolite chebi:30623
formate Metabolite chebi:15740
I- Metabolite chebi:16382
Lactate Metabolite chebi:24996
Na+ Metabolite chebi:29101
urate Metabolite chebi:46818
Gly Metabolite chebi:15428
Ala Metabolite chebi:16449
HPO4 2- Metabolite chebi:43474
OH- Metabolite chebi:16234
Cationic amino acids Metabolite chebi:58942
Amino acids Metabolite chebi:33709
sulfate Metabolite chebi:16189
hydrogencarbonate Metabolite chebi:17544
α-ketoglutarate Metabolite chebi:16810
K+ Metabolite chebi:29103
H+ Metabolite chebi:15378
Cl- Metabolite chebi:17996
H2CO3 Metabolite chebi:28976
H2O Metabolite chebi:15377
CO2 Metabolite chebi:16526
HCO3- Metabolite chebi:17544
Glucose Metabolite chebi:17234
Anionic amino acids Metabolite chebi:64898
H2PO4- Metabolite chebi:39745
H2PO4 - Metabolite chebi:39745
SLC47A2 GeneProduct ensembl:ENSG00000180638
ABCG2 GeneProduct ensembl:ENSG00000118777
SLC7A8 GeneProduct ensembl:ENSG00000092068
SLC47A1 GeneProduct ensembl:ENSG00000142494
ATP6V0D2 GeneProduct ensembl:ENSG00000147614
ATP6V0E1 GeneProduct ensembl:ENSG00000113732
SLC22A2 GeneProduct ensembl:ENSG00000112499
SLC7A9 GeneProduct ensembl:ENSG00000021488
SLC5A2 GeneProduct ensembl:ENSG00000140675
ATP1B1 GeneProduct ensembl:ENSG00000143153
CA4 GeneProduct ensembl:ENSG00000167434
SLC34A1 GeneProduct ensembl:ENSG00000131183
ATP6V1D GeneProduct ensembl:ENSG00000100554
SLC1A1 GeneProduct ensembl:ENSG00000106688
SLC5A8 GeneProduct ensembl:ENSG00000256870
SLC6A20 GeneProduct ensembl:ENSG00000163817
SLC4A4 GeneProduct ensembl:ENSG00000080493
ATP6V1H GeneProduct ensembl:ENSG00000047249
SLC12A4 GeneProduct ensembl:ENSG00000124067
ATP6V0A4 GeneProduct ensembl:ENSG00000105929
ATP6V1A GeneProduct ensembl:ENSG00000114573
SLC22A11 GeneProduct ensembl:ENSG00000168065
SLC3A2 GeneProduct ensembl:ENSG00000168003
TMEM27 GeneProduct ensembl:ENSG00000147003
ATP6V0B GeneProduct ensembl:ENSG00000117410
SLC16A10 GeneProduct ensembl:ENSG00000112394
SLC2A1 GeneProduct ensembl:ENSG00000117394
ATP6V1G1 GeneProduct ensembl:ENSG00000136888
SLC34A3 GeneProduct ensembl:ENSG00000198569
ABCC4 GeneProduct ensembl:ENSG00000125257
ATP1A1 GeneProduct ensembl:ENSG00000163399
SLC9A3 GeneProduct ensembl:ENSG00000066230
ABCB1 GeneProduct ensembl:ENSG00000085563
SLC5A5 GeneProduct ensembl:ENSG00000105641
FXYD2 GeneProduct ensembl:ENSG00000137731
SLC7A7 GeneProduct ensembl:ENSG00000155465
SLC6A19 GeneProduct ensembl:ENSG00000174358
ATP6V1F GeneProduct ensembl:ENSG00000128524
ATP6V1B1 GeneProduct ensembl:ENSG00000116039
SLC4A2 GeneProduct ensembl:ENSG00000164889
SLC36A2 GeneProduct ensembl:ENSG00000186335
ABCC2 GeneProduct ensembl:ENSG00000023839
ATP6V1C1 GeneProduct ensembl:ENSG00000155097
SLC6A18 GeneProduct ensembl:ENSG00000164363
SLC2A2 GeneProduct ensembl:ENSG00000163581
ATP6V1E1 GeneProduct ensembl:ENSG00000131100
SLC26A6 GeneProduct ensembl:ENSG00000225697
SLC20A2 GeneProduct ensembl:ENSG00000168575
ATP6V0C GeneProduct ensembl:ENSG00000185883
SLC3A1 GeneProduct ensembl:ENSG00000138079
AQP1 GeneProduct ensembl:ENSG00000240583
CA2 GeneProduct ensembl:ENSG00000104267
SLC5A1 GeneProduct ensembl:ENSG00000100170
SLC22A7 GeneProduct ensembl:ENSG00000137204
SLC22A6 GeneProduct ensembl:ENSG00000197901
SLC22A8 GeneProduct ensembl:ENSG00000149452
SLC13A3 GeneProduct ensembl:ENSG00000158296

References

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