EDA signaling in hair follicle development (WP3930)

Homo sapiens

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EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

Authors

Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway nuclear factor kappa B signaling pathway altered nuclear factor kappa B signaling pathway

Cell Type Ontology

hair follicle cell

Participants
Query Drugst.One

Label Type Compact URI Comment
EDAR GeneProduct ensembl:ENSG00000135960 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003227
EDARADD GeneProduct ensembl:ENSG00000186197 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000095105
DKK4 GeneProduct ensembl:ENSG00000104371 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031535
DKK1 GeneProduct ensembl:ENSG00000107984 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024868
BMP1 GeneProduct ensembl:ENSG00000168487 BMP Not Specified
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022098
SOSTDC1 GeneProduct ensembl:ENSG00000171243 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036169
SHH GeneProduct ensembl:ENSG00000164690 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002633
GLI1 GeneProduct ensembl:ENSG00000111087 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025407
PTCH1 GeneProduct ensembl:ENSG00000185920 Ptc Not Specified
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021466
LTB GeneProduct ensembl:ENSG00000227507 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024399
RELB GeneProduct ensembl:ENSG00000104856 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002983
EDA Protein ensembl:ENSG00000158813 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3UV69
EDA Protein ensembl:ENSG00000158813 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1L2D9
WNT3 Protein ensembl:ENSG00000108379 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A2A649

References

  1. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142–7. PubMed Europe PMC Scholia