Eicosanoid synthesis (WP1318)

Danio rerio

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]


Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz


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Danio rerio



Pathway Ontology

eicosanoid biosynthetic pathway


Label Type Compact URI Comment
5-HPETE Metabolite hmdb:HMDB0001193
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Leukotriene D4 Metabolite hmdb:HMDB0003080
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Leukotriene A4 Metabolite hmdb:HMDB0001337
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Leukotriene C4 Metabolite hmdb:HMDB0001198
Leukotriene E4 Metabolite hmdb:HMDB0002200
Thromboxane A2 Metabolite hmdb:HMDB0001452
Arachidonic acid Metabolite hmdb:HMDB0001043
Leukotriene B4 Metabolite hmdb:HMDB0001085
LOC791800 GeneProduct ncbigene:791800
PTGDS GeneProduct ncbigene:336492
ptgesl GeneProduct ncbigene:799964
zgc:153024 GeneProduct ncbigene:768195
ptgisl GeneProduct ncbigene:559148
DKEY-194N13.2 GeneProduct ncbigene:567204
tbxas1 GeneProduct ncbigene:792041
ptgs1 GeneProduct ncbigene:246226
GGT1 GeneProduct ncbigene:393387
pla2g6 GeneProduct ncbigene:406370
ptges GeneProduct ncbigene:544666
pla2g6 GeneProduct ncbigene:406370
DKEY-194N13.2 GeneProduct ncbigene:567204
lta4h GeneProduct ncbigene:406575
ptgs2b GeneProduct ncbigene:559020
LOC567284 GeneProduct ncbigene:567284
LOC791800 GeneProduct ncbigene:791800
alox12 GeneProduct ncbigene:322732


  1. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia