Neural crest differentiation (WP2064)
Homo sapiens
Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143 When citing this pathway, please reference the source publication (PMID: 19575671). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2064 CPTAC Assay Portal]
Authors
Nathan Salomonis , Kristina Hanspers , Zahra Roudbari , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders (2022).
- A proteomic signature that reflects pancreatic beta-cell function (2018).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathwayCell Type Ontology
neural crest derived neuron migratory cranial neural crest cellReferences
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- The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, et al. Biochem J. 2006 Apr 15;395(2):355–61. PubMed Europe PMC Scholia
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- Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar. Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, et al. BMC Dev Biol. 2010 Nov 25;10:115. PubMed Europe PMC Scholia
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