Delta-Notch signaling pathway (WP265)

Mus musculus

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Authors

Akhilesh Pandey , Alex Pico , Christine Chichester , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

Notch signaling pathway

Participants

Label Type Compact URI Comment
Notch1 GeneProduct ncbigene:18128
Notch2 GeneProduct ncbigene:18129
Notch3 GeneProduct ncbigene:18131
Notch4 GeneProduct ncbigene:18132
Dll1 GeneProduct ncbigene:13388
Dll4 GeneProduct ncbigene:54485
Jag1 GeneProduct ncbigene:16449
Jag2 GeneProduct ncbigene:16450
Psen1 GeneProduct ncbigene:19164
Psen2 GeneProduct ncbigene:19165
Gm15429 GeneProduct ncbigene:100039623
Aph1b GeneProduct ncbigene:208117
PSENEN GeneProduct ncbigene:66340
Ncstn GeneProduct ncbigene:59287
Adam10 GeneProduct ncbigene:11487
Adam17 GeneProduct ncbigene:11491
Gsk3b GeneProduct ncbigene:56637
Numb GeneProduct ncbigene:18222
Itch GeneProduct ncbigene:16396
App GeneProduct ncbigene:11820
Numbl GeneProduct ncbigene:18223
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Akt1 GeneProduct ncbigene:11651
Furin GeneProduct ncbigene:18550
Cntn1 GeneProduct ncbigene:12805
Nov GeneProduct ncbigene:18133
Dtx1 GeneProduct ncbigene:14357
Ascl1 GeneProduct ncbigene:17172
Ep300 GeneProduct ncbigene:328572
Trp53 GeneProduct ncbigene:22059
Lfng GeneProduct ncbigene:16848
Mfng GeneProduct ncbigene:17305
Pofut1 GeneProduct ncbigene:140484
SKP1A GeneProduct ncbigene:21402
Fbxw7 GeneProduct ncbigene:50754
Hey1 GeneProduct ncbigene:15213
Maml2 GeneProduct ncbigene:270118
Maml3 GeneProduct ncbigene:433586
Maml1 GeneProduct ncbigene:103806
SNW1 GeneProduct ncbigene:66354
Ncor2 GeneProduct ncbigene:20602
Ncor1 GeneProduct ncbigene:20185
Hdac1 GeneProduct ncbigene:433759
1700023B02Rik GeneProduct ncbigene:66935
Sap30 GeneProduct ncbigene:60406
Hdac2 GeneProduct ncbigene:15182
Sin3a GeneProduct ncbigene:20466
Hes1 GeneProduct ncbigene:15205
Stat3 GeneProduct ncbigene:20848
Jak2 GeneProduct ncbigene:16452
Rela GeneProduct ncbigene:19697
Nfkbia GeneProduct ncbigene:18035
Hey2 GeneProduct ncbigene:15214
Tle1 GeneProduct ncbigene:21885
Smad3 GeneProduct ncbigene:17127
Smad4 GeneProduct ncbigene:17128
Yy1 GeneProduct ncbigene:22632
Cdk2 GeneProduct ncbigene:12566
Lef1 GeneProduct ncbigene:16842
Mef2c GeneProduct ncbigene:17260
Cul1 GeneProduct ncbigene:26965
Skp2 GeneProduct ncbigene:27401
Gm9840 GeneProduct ncbigene:100043674
Tcfe2a GeneProduct ncbigene:21423
Mapk3 GeneProduct ncbigene:26417
Mapk1 GeneProduct ncbigene:26413
Wdr12 GeneProduct ncbigene:57750
Fhl1 GeneProduct ncbigene:14199
Ring1 GeneProduct ncbigene:19763
Hivep3 GeneProduct ncbigene:16656
Spen GeneProduct ncbigene:56381
Smad1 GeneProduct ncbigene:17125
Hes6 GeneProduct ncbigene:55927
Zfpm1 GeneProduct ncbigene:22761
MAGEA1 GeneProduct ncbigene:17137
Cntfr GeneProduct ncbigene:12804
Cntf GeneProduct ncbigene:12803
Hes5 GeneProduct ncbigene:15208
Lck GeneProduct ncbigene:16818
Jun GeneProduct ncbigene:16476
Rbpj GeneProduct ncbigene:19664
Egf GeneProduct ncbigene:13645
Egfr GeneProduct ncbigene:13649

References