Conversion of angiotensinogen to angiotensin II (WP4818)

Homo sapiens

This pathway depicts the conversion of Angiotensinogen to Angiotensin II by enzymes of the Renin-Angiotensin-System (RAS) and Nonrenin-Angiotensin-System (NRAS). The NRAS pathway includes both direct and indirect conversion.


Lara Vreeswijk , Friederike Ehrhart , and Eric Weitz


last edited

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Homo sapiens



Pathway Ontology

classic metabolic pathway angiotensin II signaling pathway


Label Type Compact URI Comment
Angiotensinogen Metabolite chebi:2720
human angiotensin II Metabolite chebi:2719
Angiotensin I Metabolite chebi:2718
ACE GeneProduct ensembl:ENSG00000159640
CMA1 Protein uniprot:P23946
CTSG Protein uniprot:P08311
CTSG Protein uniprot:P08311
CTSD Protein uniprot:A0A1B0GV23
REN Protein uniprot:A0A1B0GUZ2


  1. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. Karlsson C, Lindell K, Ottosson M, Sjöström L, Carlsson B, Carlsson LM. J Clin Endocrinol Metab. 1998 Nov;83(11):3925–9. PubMed Europe PMC Scholia