HSPB3 (WP5524)

Homo sapiens

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Role of HSPB3 in Charcot Marie Tooth disease (CMT)

Authors

Oqbehm and Alex Pico

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

disease pathway

Disease Ontology

Charcot-Marie-Tooth disease

Participants
Query Drugst.One

Label Type Compact URI Comment
ACTA1 GeneProduct uniprot:P68133
LBR GeneProduct uniprot:Q14739
DES GeneProduct uniprot:P17661
MYOG GeneProduct uniprot:P15173
HSPB2 Protein uniprot:Q16082
CBX5 Protein uniprot:P45973 aka HP1 (heterochromatin protein 1)
DMPK Protein uniprot:Q09013
HP1BP3 Protein uniprot:Q5SSJ5 ad
LMNA Protein uniprot:P02545
NOTCH3 Protein uniprot:Q9UM47
H2AZ Protein uniprot:P0C0S5
MYOD Protein uniprot:P15172
HSPB3 Protein uniprot:Q12988
LMNB1 Protein uniprot:P20700
LBR Protein uniprot:Q14739
MEF2C Protein uniprot:Q06413

References

  1. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. Ye Q, Worman HJ. J Biol Chem. 1994 Apr 15;269(15):11306–11. PubMed Europe PMC Scholia
  2. Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. Ye Q, Callebaut I, Pezhman A, Courvalin JC, Worman HJ. J Biol Chem. 1997 Jun 6;272(23):14983–9. PubMed Europe PMC Scholia
  3. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, et al. J Cell Biol. 1998 Mar 9;140(5):1113–24. PubMed Europe PMC Scholia
  4. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, et al. J Biol Chem. 2000 Jan 14;275(2):1095–104. PubMed Europe PMC Scholia
  5. The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development. Wang DZ, Valdez MR, McAnally J, Richardson J, Olson EN. Development. 2001 Nov;128(22):4623–33. PubMed Europe PMC Scholia
  6. mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo. Dodou E, Xu SM, Black BL. Mech Dev. 2003 Sep;120(9):1021–32. PubMed Europe PMC Scholia
  7. H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding. Fan JY, Rangasamy D, Luger K, Tremethick DJ. Mol Cell. 2004 Nov 19;16(4):655–61. PubMed Europe PMC Scholia
  8. The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA. Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, et al. J Biol Chem. 2010 Feb 26;285(9):6498–507. PubMed Europe PMC Scholia
  9. Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts. Gagan J, Dey BK, Layer R, Yan Z, Dutta A. J Biol Chem. 2012 Nov 23;287(48):40360–70. PubMed Europe PMC Scholia
  10. LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, et al. Cell. 2013 Jan 31;152(3):584–98. PubMed Europe PMC Scholia
  11. Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. Tiago T, Hummel B, Morelli FF, Basile V, Vinet J, Galli V, et al. Cell Death Dis. 2021 May 6;12(5):452. PubMed Europe PMC Scholia