Eicosanoid synthesis (WP972)

Bos taurus

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In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

eicosanoid biosynthetic pathway inflammatory response pathway

Cell Type Ontology

epithelial cell

Participants

Label Type Compact URI Comment
5-HETE Metabolite cas:70608-72-9
5-HPETE Metabolite hmdb:HMDB0001193
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Leukotriene D4 Metabolite hmdb:HMDB0003080
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Leukotriene A4 Metabolite hmdb:HMDB0001337
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Leukotriene C4 Metabolite hmdb:HMDB0001198
Leukotriene E4 Metabolite hmdb:HMDB0002200
12-HETE Metabolite cas:70608-72-9
15-HETE Metabolite cas:70608-72-9
Thromboxane A2 Metabolite hmdb:HMDB0001452
Arachidonic acid Metabolite hmdb:HMDB0001043
Leukotriene B4 Metabolite hmdb:HMDB0001085
12-HPETE Metabolite cas:71030-35-8
15-HPETE Metabolite cas:70981-96-3
Prostaglandin E2 Metabolite cas:363-24-6
ALOX5AP GeneProduct ensembl:ENSBTAG00000013201 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:241
PTGDS GeneProduct ensembl:ENSBTAG00000015074 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5730
PTGES2 GeneProduct ensembl:ENSBTAG00000016218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80142
DPEP1 GeneProduct ensembl:ENSBTAG00000033326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1800
PTGIS GeneProduct ensembl:ENSBTAG00000017537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5740
PLA2G2A GeneProduct ensembl:ENSBTAG00000005759 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5320
ALOX5 GeneProduct ensembl:ENSBTAG00000020319 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:240
PNPLA3 GeneProduct ensembl:ENSBTAG00000045746 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PNPLA3
TBXAS1 GeneProduct ensembl:ENSBTAG00000020225 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6916
PTGS1 GeneProduct ensembl:ENSBTAG00000006716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5742
GGT1 GeneProduct ensembl:ENSBTAG00000046900 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2678
PLA2G6 GeneProduct ensembl:ENSBTAG00000014015 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8398
ALOX15 GeneProduct ensembl:ENSBTAG00000011990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:246
ALOX15B GeneProduct ensembl:ENSBTAG00000008779 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:247
PTGES GeneProduct ensembl:ENSBTAG00000019453 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9536
ALOX5 GeneProduct ensembl:ENSBTAG00000020319 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:240
LTA4H GeneProduct ensembl:ENSBTAG00000016415 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4048
PGHS-2 GeneProduct ensembl:ENSBTAG00000014127 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
LTC4S GeneProduct ensembl:ENSBTAG00000009737 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4056
ALOX15 GeneProduct ensembl:ENSBTAG00000011990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:246
ALOX5AP GeneProduct ensembl:ENSBTAG00000013201 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:241
PNPLA8 GeneProduct ensembl:ENSBTAG00000024387 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50640
ALOX12 GeneProduct ensembl:ENSBTAG00000021933 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:239

References

  1. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia