Oxidation by cytochrome P450 (WP1274)

Mus musculus

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.


Christine Chichester , Kristina Hanspers , Eric Weitz , Alex Pico , and Lars Willighagen


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Mus musculus



Pathway Ontology

phase I biotransformation pathway via cytochrome P450


Label Type Compact Identifier Comment
NADPH Metabolite chebi:16474
O2 Metabolite hmdb:HMDB0001377
O2 Metabolite hmdb:HMDB0001377
Fe3+ Metabolite chebi:29034
Water Metabolite hmdb:HMDB0002111
NADP+ Metabolite chebi:18009
Fe3+ Metabolite chebi:29034
Fe3+ Metabolite chebi:29034
Fe2+ Metabolite chebi:29033
Fe2+ Metabolite chebi:29033
Fe2+ Metabolite chebi:29033
Fe3+ Metabolite chebi:29034
Fe2+ Metabolite chebi:29033
NADH Metabolite chebi:16908
NAD+ Metabolite chebi:15846
Cyp26a1 GeneProduct ensembl:ENSMUSG00000024987
Cyb5b GeneProduct ensembl:ENSMUSG00000031924
Cyb5r1 GeneProduct ensembl:ENSMUSG00000026456
Cyp4f39 GeneProduct ensembl:ENSMUSG00000061126
Cyb5 GeneProduct ensembl:ENSMUSG00000024646
Cyp1b1 GeneProduct ensembl:ENSMUSG00000024087
Cyb5r4 GeneProduct ensembl:ENSMUSG00000032872
Cyb5b GeneProduct ensembl:ENSMUSG00000031924
Cyb5r2 GeneProduct ensembl:ENSMUSG00000048065
Cyp11b1 GeneProduct ncbigene:110115
Cyp27b1 GeneProduct ensembl:ENSMUSG00000006724
Cyp4f18 GeneProduct ensembl:ENSMUSG00000003484
Cyp26c1 GeneProduct ensembl:ENSMUSG00000062432
Cyp51 GeneProduct ensembl:ENSMUSG00000001467
Cyb5b GeneProduct ensembl:ENSMUSG00000031924
Cyp7b1 GeneProduct ensembl:ENSMUSG00000039519
Cyp19a1 GeneProduct ensembl:ENSMUSG00000032274
Cyp21a1 GeneProduct ensembl:ENSMUSG00000024365
Cyp26b1 GeneProduct ensembl:ENSMUSG00000063415
Cyp7a1 GeneProduct ensembl:ENSMUSG00000028240
AC161058.2-1 GeneProduct ensembl:ENSMUSG00000029541
Cyp8b1 GeneProduct ensembl:ENSMUSG00000050445
Cyp2s1 GeneProduct ensembl:ENSMUSG00000040703
Cyp39a1 GeneProduct ensembl:ENSMUSG00000023963
Cyp2r1 GeneProduct ensembl:ENSMUSG00000030670
Cyp46a1 GeneProduct ensembl:ENSMUSG00000021259
Cyp4b1 GeneProduct ensembl:ENSMUSG00000028713
Cyp1a2 GeneProduct ensembl:ENSMUSG00000032310
Cyp4v3 GeneProduct ensembl:ENSMUSG00000079057
Cyp2u1 GeneProduct ensembl:ENSMUSG00000027983
Cyp4x1 GeneProduct ensembl:ENSMUSG00000047155
Cyp51 GeneProduct ensembl:ENSMUSG00000001467
Cyp2e1 GeneProduct ensembl:ENSMUSG00000025479
Cyp11a1 GeneProduct ensembl:ENSMUSG00000032323
Cyp20a1 GeneProduct ensembl:ENSMUSG00000049439
Por GeneProduct ensembl:ENSMUSG00000005514
Cyp17a1 GeneProduct ensembl:ENSMUSG00000003555
Cyp27a1 GeneProduct ensembl:ENSMUSG00000026170
Cyp2f2 GeneProduct ensembl:ENSMUSG00000052974
Cyb5r3 GeneProduct ensembl:ENSMUSG00000018042
Cyp11b2 GeneProduct ncbigene:13072
Cyp24a1 GeneProduct ensembl:ENSMUSG00000038567
Cyp1a1 GeneProduct ensembl:ENSMUSG00000032315
Cyb5 GeneProduct ensembl:ENSMUSG00000024646
Cyb5 GeneProduct ensembl:ENSMUSG00000024646


  1. Hollinger MA, Niesink R, De Vries J. Toxicology [Internet]. Boca Raton, FL: CRC Press; 1996. 1284 p. Available from: https://openlibrary.org/books/OL791209M/Toxicology OpenLibrary Worldcat