Superpathway of branched chain amino acid biosynthesis (WP198)
Saccharomyces cerevisiae
The biosynthesis of branched-chain amino acids (BCAA) in S. cerevisiae involves a common pathway that metabolizes pyruvate to valine or -ketobutyrate (derived from threonine) to isoleucine. This pathway occurs in the mitochondrion until the final step, where the immediate precursor to valine or isoleucine is converted to its respective amino acid either in the mitochondrion (via Bat1p) or the cytosol (via Bat2p). In a branch of the common pathway, valines immediate precursor can instead be converted to -isopropylmalate via -isopropylmalate synthase (Leu4p and Leu9p), which is subsequently exported to the cytosol and metabolized to leucine in three additional steps.
Authors
Jessica Heckman , Daniela Digles , Egon Willighagen , Eric Weitz , and Kristina HanspersActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
valine, leucine and isoleucine biosynthetic pathway classic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (R)-2,3-dihydroxy-3-methylpentanoate | Metabolite | chebi:49258 | |
| 3-methyl-2-oxobutanoate | Metabolite | chebi:11851 | |
| L-glutamate | Metabolite | chebi:29985 | |
| 2-isopropylmaleate | Metabolite | chebi:58085 | |
| NAD+ | Metabolite | chebi:57540 | |
| NADP+ | Metabolite | chebi:58349 | |
| L-threonine | Metabolite | cas:72-19-5 | |
| H+ | Metabolite | hmdb:HMDB59597 | |
| (2S)-2-isopropyl-3-oxosuccinate | Metabolite | chebi:17214 | |
| 2-iminobutanoate | Metabolite | pubchem.compound:19796801 | |
| 4-methyl-2-oxopentanoate | Metabolite | chebi:17865 | |
| 2-oxobutanoate | Metabolite | chebi:16763 | |
| NADH | Metabolite | cas:53-84-9 | |
| (S)-2-aceto-2-hydroxybutanoate | Metabolite | chebi:49256 | |
| L-Valine | Metabolite | cas:72-18-4 | |
| pyruvate | Metabolite | chebi:15361 | |
| (2R)-2,3-dihydroxy-3-methylbutanoate | Metabolite | chebi:49072 | |
| L-isoleucine | Metabolite | chebi:58045 | |
| NH4+ | Metabolite | chebi:28938 | |
| (3S)-3-methyl-2-oxopentanoate | Metabolite | chebi:35146 | |
| NADPH | Metabolite | cas:53-57-6 | |
| CO2 | Metabolite | chebi:16526 | |
| 2-oxoglutarate | Metabolite | chebi:16810 | |
| Coenzyme A | Metabolite | cas:64885-97-8 | |
| (S)-2-acetolactate | Metabolite | chebi:58476 | |
| (2S)-2-isopropylmalate | Metabolite | chebi:1178 | |
| L-glutamate | Metabolite | cas:56-86-0 | |
| (Z)-2-aminobutenoate | Metabolite | chebi:58739 | |
| H2O | Metabolite | hmdb:HMDB02111 | |
| acetyl-CoA | Metabolite | cas:72-89-9 | |
| L-leucine | Metabolite | cas:61-90-5 | |
| BAT1 | GeneProduct | sgd:S000001251 | |
| ILV1 | GeneProduct | sgd:S000000888 | |
| LEU9 | GeneProduct | sgd:S000005634 | minor isozyme |
| ILV3 | GeneProduct | sgd:S000003777 | |
| ILV5 | GeneProduct | sgd:S000004347 | |
| BAT2 | GeneProduct | sgd:S000003909 | |
| LEU4 | GeneProduct | sgd:S000005048 | |
| ILV6 | GeneProduct | sgd:S000000515 | |
| ILV2 | GeneProduct | sgd:S000004714 | |
| LEU2 | GeneProduct | sgd:S000000523 | |
| LEU1 | GeneProduct | sgd:S000002977 |