Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins (WP4936)

Homo sapiens

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection

Authors

Rex D A B , Egon Willighagen , Friederike Ehrhart , Marvin Martens , Eric Weitz , Finterly Hu , Kristina Hanspers , Martina Summer-Kutmon , and Nhung Pham

Activity

last edited

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

infectious disease pathway altered autophagy pathway

Disease Ontology

COVID-19

Participants

Label Type Compact URI Comment
LARP1 GeneProduct ensembl:ENSG00000155506
PPP1R9A GeneProduct ensembl:ENSG00000158528 Also known as NRB1
MAP1LC3B GeneProduct ncbiprotein:81631
ATG4A GeneProduct ensembl:ENSG00000101844
P70S6K GeneProduct ensembl:ENSG00000108443
RB1CC1 GeneProduct ensembl:ENSG00000023287
VPS18 GeneProduct ensembl:ENSG00000104142
AKT1S1 GeneProduct ensembl:ENSG00000204673
orf3 GeneProduct uniprot:P0DTC3 orf3 has no identifiers, but orf3a and orf3b do, and orf3a is the only one with enough amino acids to be structure in Figure 3
VPS33A GeneProduct ensembl:ENSG00000139719
VPS39 GeneProduct ensembl:ENSG00000166887
orf3 GeneProduct uniprot:P0DTC3 orf3 has no identifiers, but orf3a and orf3b do, and orf3a is the only one with enough amino acids to be structure in Figure 3
EIF4B GeneProduct ensembl:ENSG00000063046
LAMP2 GeneProduct ensembl:ENSG00000005893
APOB GeneProduct ensembl:ENSG00000084674
NBR1 GeneProduct ensembl:ENSG00000188554
VAMP8 GeneProduct ensembl:ENSG00000118640
TMEM59 GeneProduct ensembl:ENSG00000116209
LAMTOR1 GeneProduct ensembl:ENSG00000149357
ATG2B GeneProduct ensembl:ENSG00000066739
orf3 GeneProduct uniprot:P0DTC3 orf3 has no identifiers, but orf3a and orf3b do, and orf3a is the only one with enough amino acids to be structure in Figure 3
MLST8 Protein ncbiprotein:64223
ATG5 Protein ncbiprotein:9474
VPS16 Protein ncbiprotein:64601
VPS11 Protein ncbiprotein:55823
ATG13 Protein ncbiprotein:9776
AMPK Protein ncbiprotein:5563
TAX1BP1 Protein ncbiprotein:8887
PKM Protein ncbiprotein:5315
SQSTM1 Protein ncbiprotein:8878
OPTN Protein ncbiprotein:10133
ATG7 Protein ncbiprotein:10533
RAB7A Protein ncbiprotein:7879
VPS41 Protein ncbiprotein:27072
CALCOCO2 Protein ncbiprotein:10241
GABARAPL2 Protein ncbiprotein:11345
MTOR Protein ncbiprotein:2475
ATG3 Protein ncbiprotein:64422
DEPTOR Protein ncbiprotein:64798
RPS6 Protein ncbiprotein:6194
ATG12 Protein ncbiprotein:9140
AKT1 Protein uniprot:P31749
ATG16L Protein ncbiprotein:55054
RHEB Protein ncbiprotein:6009
RPTOR Protein ncbiprotein:57521
ULK1 Protein ncbiprotein:8408
ATG9A Protein ncbiprotein:79065
GSK3 Protein ncbiprotein:P31749
TSC2 Protein ncbiprotein:P31749
nsp6 Protein ncbiprotein:YP_009725302

References

  1. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, et al. Nature. 2021 Jun;594(7862):246–52. PubMed Europe PMC Scholia