TYROBP causal network in microglia (WP3945)

Homo sapiens

Authors

Kristina Hanspers , Alex Pico , and Eric Weitz

Activity

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Cited In

• DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
• Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients (2020).
• A Cross-Species Systems Genetics Analysis Links APBB1IP as a Candidate for Schizophrenia and Prepulse Inhibition (2019).
• Identification of potential drug targets for vascular dementia and carotid plaques by analyzing underlying molecular signatures shared by them (2022).

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

microglial cell

Disease Ontology

Alzheimer's disease

Pathway Ontology

innate immune response pathway Alzheimer's disease pathway

References

1. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, et al. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia