TYROBP causal network in microglia (WP3945)

Homo sapiens

The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3945 CPTAC Assay Portal]

Authors

Kristina Hanspers , Alex Pico , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

innate immune response pathway innate immune response pathway Alzheimer's disease pathway

Cell Type Ontology

microglial cell microglial cell

Disease Ontology

Alzheimer's disease

Participants

Label Type Compact URI Comment
GIMAP2 GeneProduct ensembl:ENSG00000106560
TCIRG1 GeneProduct ensembl:ENSG00000110719 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001750
DPYD GeneProduct ensembl:ENSG00000188641 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033308
SAMSN1 GeneProduct ensembl:ENSG00000155307 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022876
IL13RA1 GeneProduct ensembl:ENSG00000131724 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000017057
GPX1 GeneProduct ensembl:ENSG00000233276 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063856
LGALS9C GeneProduct ensembl:ENSG00000171916
ITGAM GeneProduct ensembl:ENSG00000169896 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786
BIN2 GeneProduct ensembl:ENSG00000110934 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000098112
PPP1R18 GeneProduct ensembl:ENSG00000146112 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034595
IGSF6 GeneProduct ensembl:ENSG00000140749 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035004
PYCARD GeneProduct ensembl:ENSG00000103490 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030793
NCKAP1L GeneProduct ensembl:ENSG00000123338 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488
SLC1A5 GeneProduct ensembl:ENSG00000105281 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001918
FKBP15 GeneProduct ensembl:ENSG00000119321 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000066151
NPC2 GeneProduct ensembl:ENSG00000119655 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021242
CXCL16 GeneProduct ensembl:ENSG00000161921 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018920
TYROBP GeneProduct ensembl:ENSG00000011600 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579
HLX GeneProduct ensembl:ENSG00000136630 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039377
CD4 GeneProduct ensembl:ENSG00000010610 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023274
ABCC4 GeneProduct ensembl:ENSG00000125257 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032849
SLC7A7 GeneProduct ensembl:ENSG00000155465 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000958
RBM47 GeneProduct ensembl:ENSG00000163694 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000070780
APBB1IP GeneProduct ensembl:ENSG00000077420 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026786
C1QC GeneProduct ensembl:ENSG00000159189 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896
ITGB2 GeneProduct ensembl:ENSG00000160255 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290
ADAP2 GeneProduct ensembl:ENSG00000184060 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020709
TMEM106A GeneProduct ensembl:ENSG00000184988 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034947
CAPG GeneProduct ensembl:ENSG00000042493 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000056737
STAT5A GeneProduct ensembl:ENSG00000126561 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004043
ELF4 GeneProduct ensembl:ENSG00000102034 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031103
RPS6KA1 GeneProduct ensembl:ENSG00000117676 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003644
SPP1 GeneProduct ensembl:ENSG00000118785 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029304
CREB3L2 GeneProduct ensembl:ENSG00000182158 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038648
ZFP36L2 GeneProduct ensembl:ENSG00000152518 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045817
RUNX3 GeneProduct ensembl:ENSG00000020633 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000070691
PLEK GeneProduct ensembl:ENSG00000115956 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
NRROS GeneProduct ensembl:ENSG00000174004 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052384
LYL1 GeneProduct ensembl:ENSG00000104903 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034041
LOXL3 GeneProduct ensembl:ENSG00000115318 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000693
C3 GeneProduct ensembl:ENSG00000125730 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024164
NCF2 GeneProduct ensembl:ENSG00000116701 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480
GAPT GeneProduct ensembl:ENSG00000175857 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046006
CD37 GeneProduct ensembl:ENSG00000104894 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030798
TGFBR1 GeneProduct ensembl:ENSG00000106799 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000007613
GAL3ST4 GeneProduct ensembl:ENSG00000197093 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000075593
CD84 GeneProduct ensembl:ENSG00000066294 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038147
ITGAX GeneProduct ensembl:ENSG00000140678 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030789
RNASE6 GeneProduct ensembl:ENSG00000169413 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021880
HCLS1 GeneProduct ensembl:ENSG00000180353 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022831
IL10RA GeneProduct ensembl:ENSG00000110324 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032089
SH2B3 GeneProduct ensembl:ENSG00000111252 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042594
CYTL1 GeneProduct ensembl:ENSG00000170891 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000062329
TNFRSF1B GeneProduct ensembl:ENSG00000028137 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028599
RGS1 GeneProduct ensembl:ENSG00000090104 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026358
IL18 GeneProduct ensembl:ENSG00000150782 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039217
KCNE3 GeneProduct ensembl:ENSG00000175538 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035165
SFT2D2 GeneProduct ensembl:ENSG00000213064 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040848
MAF GeneProduct ensembl:ENSG00000178573 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000055435
LHFPL2 GeneProduct ensembl:ENSG00000145685 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045312

References

  1. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, et al. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia