Toll-like receptor signaling related to MyD88 (WP3858)
This pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflammation in the body and in the cancerous cells. TLR signaling pathways are usually connected with MyD88 dependent pathways and MyD88 independent pathways. TLR pathways that involve MyD88 dependent pathways such as this one involve IRAK complexes. The finding of TLR or NFkB genes within the body usually correlates with breast cancer within the person. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3858 CPTAC Assay Portal].
AuthorsAAR&Co , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Denise Slenter , and Eric Weitz
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- Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlations (2021).
- Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
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Pathway Ontologydisease pathway breast cancer pathway Toll-like receptor signaling pathway immune response pathway cancer pathway
- Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study. Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, et al. BMC Cancer. 2013 May 1;13:219. PubMed Europe PMC Scholia