Toll-like receptor signaling related to MyD88 (WP3858)

Homo sapiens

This pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflammation in the body and in the cancerous cells. TLR signaling pathways are usually connected with MyD88 dependent pathways and MyD88 independent pathways. TLR pathways that involve MyD88 dependent pathways such as this one involve IRAK complexes. The finding of TLR or NFkB genes within the body usually correlates with breast cancer within the person. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal].


AAR&Co , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Denise Slenter , and Eric Weitz


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Homo sapiens



Pathway Ontology

disease pathway breast cancer pathway Toll-like receptor signaling pathway immune response pathway cancer pathway

Disease Ontology



Label Type Compact URI Comment
TLR5 GeneProduct ensembl:ENSG00000187554
TLR7 GeneProduct ensembl:ENSG00000196664
TLR8 GeneProduct ensembl:ENSG00000101916
TLR9 GeneProduct ensembl:ENSG00000239732
MYD88 GeneProduct ensembl:ENSG00000172936
IRAK4 GeneProduct ensembl:ENSG00000198001
IRAK1 GeneProduct ensembl:ENSG00000184216
TIRAP GeneProduct ensembl:ENSG00000150455
TLR4 GeneProduct ensembl:ENSG00000136869
TLR1 GeneProduct ensembl:ENSG00000174125
TLR2 GeneProduct ensembl:ENSG00000137462
TLR2 GeneProduct ensembl:ENSG00000137462
TLR6 GeneProduct ensembl:ENSG00000174130
TOLLIP GeneProduct ensembl:ENSG00000078902
TIRAP GeneProduct ensembl:ENSG00000150455
TRAF6 GeneProduct ensembl:ENSG00000175104
TLR4 GeneProduct ensembl:ENSG00000136869
TLR3 GeneProduct ensembl:ENSG00000164342
TICAM2 GeneProduct ensembl:ENSG00000243414
TICAM1 GeneProduct ensembl:ENSG00000127666
TRAF3 GeneProduct ensembl:ENSG00000131323
IKBKE GeneProduct ensembl:ENSG00000263528
TBK1 GeneProduct ensembl:ENSG00000183735
IRF3 GeneProduct ensembl:ENSG00000126456
IRF7 GeneProduct ensembl:ENSG00000185507
IKBKB GeneProduct ensembl:ENSG00000104365
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKB2 GeneProduct ensembl:ENSG00000077150
RELA GeneProduct ncbigene:5970
RELB GeneProduct ncbigene:5971
c-REL GeneProduct ncbigene:5966
MAPK1 GeneProduct ensembl:ENSG00000100030
MYD88 GeneProduct ensembl:ENSG00000172936
MYD88 GeneProduct ensembl:ENSG00000172936
CHUK GeneProduct ensembl:ENSG00000213341
IKBKG GeneProduct ensembl:ENSG00000269335


  1. Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study. Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, et al. BMC Cancer. 2013 May 1;13:219. PubMed Europe PMC Scholia