Equilibrium signaling pathway of differentiated cells (WP3653)

Drosophila melanogaster

Equilibrium signalling pathway for maintenance of progenitor cells in the lymph gland which is also affected by hedgehog protein niche signaling. Nup98 and Bip1 proteins both necessary for Pvr gene expression. Pvr/STAT92E complex activates Adgf-A to break down adenosine. Break down allows for proper maintenance of progenitor cells in equilibrium signalling. Niche signalling includes the expression of hedgehog by posterior signaling center also promoting progenitor maintenance. This pathway is based on figure 7 from Mondal et al.


AAR&Co , Susan Coort , Kristina Hanspers , and Eric Weitz


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Drosophila melanogaster



Pathway Ontology

regulatory pathway signaling pathway


Label Type Compact URI Comment
RpS8 GeneProduct ensembl:FBgn0039713
bip1 GeneProduct ensembl:FBgn0026263
Nup98-96 GeneProduct ensembl:FBgn0039120
Pvr GeneProduct ensembl:FBgn0032006
Adgf-A GeneProduct ensembl:FBgn0036752
Stat92E GeneProduct ensembl:FBgn0016917
Hedgehog Protein uniprot:Q02936


  1. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. Mondal BC, Shim J, Evans CJ, Banerjee U. Elife. 2014 Sep 8;3:e03626. PubMed Europe PMC Scholia