Inflammatory bowel disease signaling (WP5198)

Homo sapiens

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Pathway representing the inflammatory bowel disease showing steps leading to Crohn's disease and ulcerative colitis.

Authors

Zuzanna Lech , Josephine-Elisabeth Pippi , Andra Waagmeester , Susan Coort , Imke Grutters , Egon Willighagen , Eric Weitz , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Toll-like receptor signaling pathway interleukin-2 signaling pathway disease pathway signaling pathway involving second messengers altered cytokine mediated signaling pathway interleukin-12 family mediated signaling pathway

Cell Type Ontology

T-helper 1 cell lymphocyte professional antigen presenting cell macrophage T-helper 17 cell naive thymus-derived CD4-positive, alpha-beta T cell colon macrophage T-helper 2 cell

Disease Ontology

immune system disease Crohn's disease colitis inflammatory bowel disease ulcerative colitis inflammatory bowel disease colonic disease

Participants
Query Drugst.One

Label Type Compact URI Comment
Peptidoglycan Metabolite chebi:8005
MDP Metabolite chebi:183049
NF-kB GeneProduct ensembl:ENSG00000109320
IL-18R-beta GeneProduct ensembl:ENSG00000115607
STAT1 GeneProduct ensembl:ENSG00000115415
IL-5 GeneProduct ensembl:ENSG00000113525
IFNG GeneProduct ensembl:ENSG00000111537
TNFA GeneProduct ensembl:ENSG00000232810
T-bet GeneProduct ensembl:ENSG00000073861
STAT6 GeneProduct ensembl:ENSG00000166888
IL-5 GeneProduct ensembl:ENSG00000113525
IL17 GeneProduct ensembl:ENSG00000112116
IL23A GeneProduct ensembl:ENSG00000110944
STAT3 GeneProduct ensembl:ENSG00000168610
IL-2RG GeneProduct ensembl:ENSG00000147168
IL-12 GeneProduct ensembl:ENSG00000168811
IL-4 GeneProduct ensembl:ENSG00000113520
IL-10 GeneProduct ensembl:ENSG00000136634
GATA3 GeneProduct ensembl:ENSG00000107485
TGFB1 GeneProduct ensembl:ENSG00000105329
IFNG GeneProduct ensembl:ENSG00000111537
FOXP3 GeneProduct ensembl:ENSG00000049768
IFNGR1 GeneProduct ensembl:ENSG00000027697
NOD2 GeneProduct ensembl:ENSG00000167207
IL6 GeneProduct ensembl:ENSG00000136244
STAT3 GeneProduct ensembl:ENSG00000168610
IL-4 GeneProduct ensembl:ENSG00000113520
IL-6 GeneProduct ensembl:ENSG00000136244
NOD2 GeneProduct ensembl:ENSG00000167207
RORA GeneProduct ensembl:ENSG00000069667
TLR2 GeneProduct ensembl:ENSG00000137462
IL12RB2 GeneProduct ensembl:ENSG00000081985
TLR2 GeneProduct ensembl:ENSG00000137462
TLR5 GeneProduct ensembl:ENSG00000187554
NF-kB GeneProduct ensembl:ENSG00000109320
IL-13 GeneProduct ensembl:ENSG00000169194
IL23R GeneProduct ensembl:ENSG00000162594
STAT4 GeneProduct ensembl:ENSG00000138378
FOXP3 GeneProduct ensembl:ENSG00000049768
IL-18 GeneProduct ensembl:ENSG00000150782
NFATC1 GeneProduct ensembl:ENSG00000131196
STAT3 GeneProduct ensembl:ENSG00000168610
IL-13 GeneProduct ensembl:ENSG00000169194
IL12RB1 GeneProduct ensembl:ENSG00000096996
IL-4 GeneProduct ensembl:ENSG00000113520
TNF GeneProduct ensembl:ENSG00000232810
TLR4 GeneProduct ensembl:ENSG00000136869
TGFB1 GeneProduct ensembl:ENSG00000105329
TLR2 GeneProduct ensembl:ENSG00000137462
AP1 GeneProduct ensembl:ENSG00000177606
IL12RB1 GeneProduct ensembl:ENSG00000096996
IL-2 GeneProduct ensembl:ENSG00000109471
IL21 GeneProduct ensembl:ENSG00000138684
IL21R GeneProduct ensembl:ENSG00000103522
TGFB GeneProduct ensembl:ENSG00000105329
IL-1 GeneProduct ensembl:ENSG00000115008
SMAD2 GeneProduct ensembl:ENSG00000175387
IL-4RA GeneProduct ensembl:ENSG00000077238
c-MAF GeneProduct ensembl:ENSG00000178573
RORyt GeneProduct ensembl:ENSG00000143365
IL22 GeneProduct ensembl:ENSG00000127318
IFNG GeneProduct ensembl:ENSG00000111537
IL-10 GeneProduct ensembl:ENSG00000136634
NF-kB GeneProduct ensembl:ENSG00000109320
MHC class 2 Protein ensembl:ENSG00000204257

References

  1. The fundamental basis of inflammatory bowel disease. Strober W, Fuss I, Mannon P. J Clin Invest. 2007 Mar;117(3):514–21. PubMed Europe PMC Scholia
  2. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease. Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, et al. Gut. 2008 Dec;57(12):1682–9. PubMed Europe PMC Scholia
  3. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. Guan Q. J Immunol Res. 2019 Dec 1;2019:7247238. PubMed Europe PMC Scholia
  4. Role of the IL23/IL17 Pathway in Crohn’s Disease. Schmitt H, Neurath MF, Atreya R. Front Immunol. 2021 Mar 30;12:622934. PubMed Europe PMC Scholia