ALA oxylipin metabolism (WP5136)

Homo sapiens

Alpha-Linolenic acid (ALA) oxylipin metabolism by ALOX5, ALOX15, and cytochrome P450.


Lucien Cayer , Martina Summer-Kutmon , Alex Pico , and Kristina Hanspers


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Homo sapiens



Pathway Ontology

classic metabolic pathway lipid metabolic pathway


Label Type Compact URI Comment
9(10)-EpODE Metabolite hmdb:HMDB10220
α-Linolenic acid Metabolite chebi:27432
15(16)-EpODE Metabolite hmdb:HMDB10206
13-HOTrE Metabolite pubchem.compound:10469728
9-OxoOTrE Metabolite cas:125559-74-2
13-HpOTrE Metabolite chebi:145300
9,10-DiHODE Metabolite hmdb:HMDB10221
9-HOTrE Metabolite pubchem.compound:10447175
12,13-DiHODE Metabolite hmdb:HMDB10201
9(S)-HpOTrE Metabolite chebi:60961
cytochrome P450 Metabolite chebi:38559
15,16-DiHODE Metabolite hmdb:HMDB10208
12(13)-EpODE Metabolite pubchem.compound:16061061
sEH GeneProduct ensembl:ENSG00000120915
ALOX15 GeneProduct ensembl:ENSG00000161905
ALOX5 GeneProduct ensembl:ENSG00000012779


  1. Lipoxygenase from potato tubers. Partial purification and properties of an enzyme that specifically oxygenates the 9-position of linoleic acid. Galliard T, Phillips DR. Biochem J. 1971 Sep;124(2):431–8. PubMed Europe PMC Scholia
  2. Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM. Adv Nutr. 2015 Sep 15;6(5):513–40. PubMed Europe PMC Scholia