Fatty acid elongation, saturated (WP380)

Saccharomyces cerevisiae

Pyridoxal phosphate (PLP) is the active form of vitamin B6 and is a cofactor in many reactions of amino acid metabolism. Pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) are all forms of vitamin B6 that can be converted to PLP via the PLP salvage pathway. Most unicellular organisms and plants can synthesize PLP, whereas mammals cannot and require vitamin B6 in their diet. Thus far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis pathway as characterized in Escherichia coli (CITS: [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]). Saccharomyces cerevisiae synthesize PLP via the fungal type de novo PLP synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of the purine-cytosine permease family (CITS: [12649274]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html


Meredith Braymer , Christine Chichester , Egon Willighagen , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Saccharomyces cerevisiae



Pathway Ontology

fatty acid biosynthetic pathway


Label Type Compact URI Comment
NADH Metabolite cas:53-84-9
palmityl-CoA Metabolite cas:1763-10-6
FAS2 GeneProduct sgd:S000006152
CEM1 GeneProduct sgd:S000000863
FAS2 GeneProduct sgd:S000006152
OAR1 GeneProduct sgd:S000001538
FAS1 GeneProduct sgd:S000001665
FAS1 GeneProduct sgd:S000001665