Complement and coagulation cascades (WP558)

Homo sapiens

Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Source: KEGG Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Thomas Kelder , Kristina Hanspers , Luis , Alex Pico , Daniela Digles , Zahra Roudbari , Egon Willighagen , Linda Rieswijk , Friederike Ehrhart , Denise Slenter , Eric Weitz , and Finterly Hu


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Homo sapiens



Pathway Ontology

complement system pathway


Label Type Compact URI Comment
Fibrin monomer Metabolite cas:9001-31-4
Bradykinin Metabolite cas:58-82-2
C2 GeneProduct ncbigene:717
PLAT GeneProduct ncbigene:5327
ADN GeneProduct ncbigene:1675
F8 GeneProduct ncbigene:2157
SERPINA5 GeneProduct ncbigene:5104
F9 GeneProduct ncbigene:2158
F2R GeneProduct ncbigene:2149
CLU GeneProduct ncbigene:1191 CLU
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SERPINA1 GeneProduct ncbigene:5265
TFPI GeneProduct ncbigene:7035
CFH GeneProduct ncbigene:3075
FGB GeneProduct ncbigene:2244
KLKB1 GeneProduct ncbigene:3818
MASP2 GeneProduct ncbigene:10747
C5R1 GeneProduct ncbigene:728
A2M GeneProduct ncbigene:2
MCP GeneProduct ncbigene:4179
F13B GeneProduct ncbigene:2165
F10 GeneProduct ncbigene:2159
F7 GeneProduct ncbigene:2155
CR2 GeneProduct ncbigene:1380
F3 GeneProduct ncbigene:2152
SERPING1 GeneProduct ncbigene:710
C1S GeneProduct ncbigene:716
C1QG GeneProduct ncbigene:714
BDKRB1 GeneProduct ncbigene:623
C7 GeneProduct ncbigene:730 MGI:88235 LL:109828
F5 GeneProduct ncbigene:2153
VWF GeneProduct ncbigene:7450
PLAU GeneProduct ncbigene:5328
SERPINF2 GeneProduct ncbigene:5345
C3AR1 GeneProduct ncbigene:719
THBD GeneProduct ncbigene:7056
Hc GeneProduct ncbigene:1213
CFI GeneProduct ncbigene:3426
F2 GeneProduct ncbigene:2147
C1R GeneProduct ncbigene:715
PROC GeneProduct ncbigene:5624
Daf1 GeneProduct ncbigene:1604
PROS1 GeneProduct ncbigene:5627
PLAUR GeneProduct ncbigene:5329
C1QB GeneProduct ncbigene:713
SERPINE1 GeneProduct ncbigene:5054
C6 GeneProduct ncbigene:729
C1QA GeneProduct ncbigene:712
C8G GeneProduct ncbigene:733
F12 GeneProduct ncbigene:2161
MBL1 GeneProduct ncbigene:3998
C9 GeneProduct ncbigene:735
SERPINC1 GeneProduct ncbigene:462
109821 GeneProduct ncbigene:109821
PLG GeneProduct ncbigene:5340
SERPIND1 GeneProduct ncbigene:3053
C3 GeneProduct ncbigene:718
H2-BF GeneProduct ncbigene:629
MASP1 GeneProduct ncbigene:5648
CPB2 GeneProduct ncbigene:1361
C4 GeneProduct ncbigene:721
KNG1 GeneProduct ncbigene:3827
CR1 GeneProduct ncbigene:1378


  1. KEGG Pathway: map04610