Glycerol teichoic acid biosynthesis (WP563)

Saccharomyces cerevisiae

The peptidoglycan layers of many gram-positive bacteria (such as Saccharomyces cerevisiae) are densely functionalized with anionic glycopolymers called wall teichoic acids (WTAs). These polymers play crucial roles in cell shape determination, regulation of cell division, and other fundamental aspects of gram-positive bacterial physiology. Additionally, WTAs are important in pathogenesis and play key roles in antibiotic resistance. Based on


Meredith Braymer , Egon Willighagen , Alex Pico , Denise Slenter , Kristina Hanspers , Eric Weitz , and Lars Willighagen


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Saccharomyces cerevisiae



Pathway Ontology

classic metabolic pathway


Label Type Compact URI Comment
CTP Metabolite chebi:17677 Cytidine triphosphate
UMP Metabolite wikidata:Q27074278 5'UMP
3 CMP Metabolite wikidata:Q412622 Cytidine monophosphate
3 CDPglycerol Metabolite wikidata:Q27102700
UDP Metabolite wikidata:Q412593 uridine 5'-diphosphate
UTP Metabolite chebi:15713 5'-UTP
undecaprenyl phosphate Metabolite chebi:27193
CMP Metabolite wikidata:Q412622 Cytidine monophosphate
undecaprenyl phosphate Metabolite chebi:27193
UDP Metabolite wikidata:Q412593
UDP-D-glucose Metabolite chebi:46229
undecanyl-diphospho-GlcNAc Metabolite wikidata:Q312208 UDP-GlcNAc aka UDP N-acetyl-glucosamine
CDPglycerol Metabolite wikidata:Q27102700 Cytidine diphosphate-glycerol
Glycerol-3-phosphate Metabolite chebi:15978
UDP-acetylmannosamine Metabolite chebi:68678
UDP-Acetyl-D-glucosamine Metabolite chebi:16264
glucose-6-phosphate Metabolite cas:59-56-3
pyrophosphate Metabolite cas:2466-09-3
glucose-1-phosphate Metabolite wikidata:Q27098367 Assuming closed form
PGM2 GeneProduct sgd:S000004711
UGP1 GeneProduct sgd:S000001518
PGM1 GeneProduct sgd:S000001610
YHL012W GeneProduct sgd:S000001004


  1. Wall teichoic acid function, biosynthesis, and inhibition. Swoboda JG, Campbell J, Meredith TC, Walker S. Chembiochem. 2010 Jan 4;11(1):35–45. PubMed Europe PMC Scholia
  2. Wall teichoic acids of gram-positive bacteria. Brown S, Santa Maria JP Jr, Walker S. Annu Rev Microbiol. 2013;67:313–36. PubMed Europe PMC Scholia