Type III interferon signaling (WP2113)

Homo sapiens

The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2113 CPTAC Assay Portal].


Shamith Samarajiwa , Martina Summer-Kutmon , and Kristina Hanspers


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Homo sapiens



Pathway Ontology

Jak-Stat signaling pathway interleukin-29 signaling pathway interleukin-28A signaling pathway interleukin-28B signaling pathway


Label Type Compact URI Comment
IRF9 GeneProduct ncbigene:10379
IL28A GeneProduct ncbigene:282616
IL29 GeneProduct ncbigene:282618
IL28B GeneProduct ncbigene:282617
JAK1 GeneProduct ncbigene:3716
IL10RB GeneProduct ncbigene:3588
TYK2 GeneProduct ncbigene:7297
IL28RA GeneProduct ncbigene:163702
STAT1 GeneProduct ncbigene:6772
STAT2 GeneProduct ncbigene:6773
STAT1 GeneProduct ncbigene:6772
STAT1 GeneProduct ncbigene:6772