The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12).
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2113 CPTAC Assay Portal].Jak-Stat signaling pathwayPW:0000209Pathway Ontologyinterleukin-29 signaling pathwayPW:0000893Pathway Ontologyinterleukin-28A signaling pathwayPW:0000891Pathway Ontologyinterleukin-28B signaling pathwayPW:0000892Pathway Ontology