G13 signaling pathway (WP298)

Mus musculus

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]


Anita Chow , Thomas Kelder , Christine Chichester , Kristina Hanspers , Egon Willighagen , and Eric Weitz


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Mus musculus



Pathway Ontology

G protein mediated signaling pathway via Galpha12/Galpha13 family


Label Type Compact URI Comment
Limk1 GeneProduct ncbigene:16885
Gna13 GeneProduct ncbigene:14674
Arhgef1 GeneProduct ncbigene:16801
Rhoa GeneProduct ncbigene:11848
Pik3r2 GeneProduct ncbigene:18709
Diap1 GeneProduct ncbigene:13367
Pfn1 GeneProduct ncbigene:18643
Pip4k2a GeneProduct ncbigene:18718
Mapk10 GeneProduct ncbigene:26414
Pkn1 GeneProduct ncbigene:320795
Mybph GeneProduct ncbigene:53311
Ppp1cb GeneProduct ncbigene:19046
Arhgdib GeneProduct ncbigene:11857
Rac1 GeneProduct ncbigene:19353
Map3k4 GeneProduct ncbigene:26407
Pak3 GeneProduct ncbigene:18481
Myl1 GeneProduct ncbigene:17901
Cit GeneProduct ncbigene:12704
Iqgap1 GeneProduct ncbigene:29875
Iqgap2 GeneProduct ncbigene:544963
Rps6kb1 GeneProduct ncbigene:72508 A41687
Rock1 GeneProduct ncbigene:19877 S69211
Rock2 GeneProduct ncbigene:19878 BAA31594
Sh3rf1 GeneProduct ncbigene:59009 Posh
Pik3ca GeneProduct ncbigene:18706
Pik3cb GeneProduct ncbigene:74769
Pik3cd GeneProduct ncbigene:18707 P42338
Cfl2 GeneProduct ncbigene:12632
Cfl1 GeneProduct ncbigene:12631
Rtkn GeneProduct ncbigene:20166
Rhpn2 GeneProduct ncbigene:52428
Arhgdig GeneProduct ncbigene:14570
Calm1 GeneProduct ncbigene:12313
Tnk2 GeneProduct ncbigene:51789 S33596
Cdc42 GeneProduct ncbigene:12540
Wasl GeneProduct ncbigene:73178
Was GeneProduct ncbigene:22376
Sra1 GeneProduct ncbigene:24068


  1. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia